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    Atp5pb ATP synthase peripheral stalk-membrane subunit b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171375, updated on 2-Nov-2024

    Summary

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    Symbol
    Atp5pbprovided by RGD
    Full Name
    ATP synthase peripheral stalk-membrane subunit bprovided by RGD
    Primary source
    RGD:620041
    See related
    EnsemblRapid:ENSRNOG00000064742 AllianceGenome:RGD:620041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp5f1
    Summary
    Contributes to ATP hydrolysis activity. Involved in cellular response to hypoxia. Part of proton-transporting ATP synthase complex, coupling factor F(o). Orthologous to human ATP5PB (ATP synthase peripheral stalk-membrane subunit b). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 5793.3), Muscle (RPKM 4106.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp5pb in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (196112459..196123737, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (193424138..193435418, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (208566385..208577147, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene adenosine A3 receptor Neighboring gene similar to human chromosome 1 open reading frame 162 Neighboring gene WD repeat domain 77 Neighboring gene uncharacterized LOC134485667

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distinct expression patterns in hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma. Lee CF, et al. World J Gastroenterol, 2008 Oct 21. PMID 18932288, Free PMC Article
    2. cDNA cloning and sequencing for the import precursor of subunit B in H(+)-ATP synthase from rat mitochondria. Tsurumi C, et al. Biochem Biophys Res Commun, 1990 May 31. PMID 2140936
    3. iTRAQ-Based Proteomic Analysis Reveals Recovery of Impaired Mitochondrial Function in Ischemic Myocardium by Shenmai Formula. Wang Y, et al. J Proteome Res, 2018 Feb 2. PMID 29300489
    4. Systematic Analysis of the Expression of the Mitochondrial ATP Synthase (Complex V) Subunits in Clear Cell Renal Cell Carcinoma. Brüggemann M, et al. Transl Oncol, 2017 Aug. PMID 28672194, Free PMC Article
    5. Mitochondrial F(0)F(1) ATP synthase. Subunit regions on the F1 motor shielded by F(0), Functional significance, and evidence for an involvement of the unique F(0) subunit F(6). Ko YH, et al. J Biol Chem, 2000 Oct 20. PMID 10887193

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase F(0) complex subunit B1, mitochondrial
    Names
    ATP synthase subunit b, mitochondrial
    ATP synthase subunit b, mitochondrial-like
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b
    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
    ATPase subunit b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134365.2 → NP_599192.1  ATP synthase F(0) complex subunit B1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_599192.1

      Status: VALIDATED

      Source sequence(s)
      BC063808, CK845764, JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P19511
      UniProtKB/TrEMBL
      A0A8L2QWG8, A6HUP1
      Related
      ENSRNOP00000021920.4, ENSRNOT00000021920.8
      Conserved Domains (1) summary
      pfam05405
      Location:83 → 244
      Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      196112459..196123737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101623.2 → XP_038957551.1  ATP synthase F(0) complex subunit B1, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8L2QWG8
      Related
      ENSRNOP00000065147.2, ENSRNOT00000075083.4
      Conserved Domains (1) summary
      pfam05405
      Location:62 → 223
      Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19511.1 GenPept UniProtKB/Swiss-Prot:P19511

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