Dbi diazepam binding inhibitor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dbiprovided by RGD
Official Full Name: diazepam binding inhibitorprovided by RGD
Primary source: RGD:2490
See related: EnsemblRapid:ENSRNOG00000046889 AllianceGenome:RGD:2490
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ep; Odn; Ttn; Acbp; Acoabp3; RNACOABP3
Summary: Enables benzodiazepine receptor binding activity and fatty-acyl-CoA binding activity. Involved in several processes, including glial cell proliferation; positive regulation of release of sequestered calcium ion into cytosol; and regulation of lipid metabolic process. Acts upstream of or within regulation of GABAergic synaptic transmission. Located in contractile muscle fiber; extracellular space; and synaptic vesicle. Orthologous to human DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 4199.0), Kidney (RPKM 2215.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (33794231..33802632, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (31241466..31249853, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (36147667..36156076, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Octadecaneuropeptide, ODN, Promotes Cell Survival against 6-OHDA-Induced Oxidative Stress and Apoptosis by Modulating the Expression of miR-34b, miR-29a, and miR-21in Cultured Astrocytes.
Title: Octadecaneuropeptide, ODN, Promotes Cell Survival against 6-OHDA-Induced Oxidative Stress and Apoptosis by Modulating the Expression of miR-34b, miR-29a, and miR-21in Cultured Astrocytes.
astrocytes produce authentic ODN, notably in a moderate oxidative stress situation, and this glio- and neuro-protective agent may form part of the brain defense mechanisms against oxidative stress injury.
Title: Endogenous Expression of ODN-Related Peptides in Astrocytes Contributes to Cell Protection Against Oxidative Stress: Astrocyte-Neuron Crosstalk Relevance for Neuronal Survival.
Data suggest that neuroglia play important role in glucose sensing in hypothalamus and may regulate energy balance/appetite control through production/secretion of endozepines (diazepam binding inhibitor and processing product, octadecaneuropeptide).
Title: Gliotransmission and brain glucose sensing: critical role of endozepines.
ACBP acts as an acyl-CoA pool former in transgenic rats and regulates lipid metabolism via SREBP-1 and PPAR regulation
Title: Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats.
Data suggest that reversible phosphorylation of ACBP regulates its ability to activate calpain in phosphatase inhibitor-induced apoptosis and controls the cellular accessibility of long-chain fatty acid-CoAs for cellular signaling.
Title: Identification of a novel phosphorylation site of acyl-CoA binding protein (ACBP) in nodularin-induced apoptotic hepatocytes.
The basal transcription of ACBP is modulated by members of the PPAR and SREBP families
Title: ACBP--a PPAR and SREBP modulated housekeeping gene.
expression of ACBP in rodent hepatocytes is subject to dual metabolic regulation by PPARalpha and SREBP-1c, which may reflect the need for ACBP during lipogenic as well as lipo-oxidative conditions
Title: The gene encoding acyl-CoA-binding protein is subject to metabolic regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes.
Cerebral DBI mRNA expression significantly increased after conditioned emotional stimuli. Cerebral DBI is enhanced by psychological stress, which is regulated by central BZD receptors.
Title: Psychological stress, but not physical stress, causes increase in diazepam binding inhibitor (DBI) mRNA expression in mouse brains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138332 (e-PCR)
- UniSTS:220419

D13Arb18 (e-PCR)
- UniSTS:239642

RH142235 (e-PCR)
- UniSTS:231484

D13Wox14 (e-PCR)
- UniSTS:517794

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables benzodiazepine receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables fatty-acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty-acyl-CoA binding	IEA Inferred from Electronic Annotation more info
enables fatty-acyl-CoA binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lateral ventricle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein lipidation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CoA-transferase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
involved_in steroid biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in contractile muscle fiber	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of protein-lipid complex	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acyl-CoA-binding protein

Names: Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenxyme A binding protein); GABA receptor modulator; LRRGT00046; diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein); diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein); diazepam binding inhibitor, acyl-CoA binding protein; diazepam binding inhibitor-like; endozepine; octadecaneuropeptide; triakontatetraneuropeptide

NP_114054.1

EC 3.4.17.3

XP_063128108.1

EC 3.4.17.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031853.4 → NP_114054.1 acyl-CoA-binding protein

See identical proteins and their annotated locations for NP_114054.1

Status: VALIDATED

Source sequence(s)

BC084717, M14201

UniProtKB/Swiss-Prot

P11030, Q2V4X5, Q63160

UniProtKB/TrEMBL

A0A8L2QZ93, A6K7Y8

Related

ENSRNOP00000089774.2, ENSRNOT00000117885.2

Conserved Domains (1) summary

cd00435
Location:2 → 86

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...