RIO2 protein kinase RIO2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RIO2
Official Full Name: protein kinase RIO2
Primary source: SGD:S000005151
Locus tag: YNL207W
See related: AllianceGenome:SGD:S000005151; FungiDB:YNL207W; VEuPathDB:YNL207W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein kinase activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and positive regulation of RNA import into nucleus. Located in cytosol and nucleus. Orthologous to human RIOK2 (RIO kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RIO2 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (255353..256630)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Release of the ribosome biogenesis factor Bud23 from small subunit precursors in yeast.
Title: Release of the ribosome biogenesis factor Bud23 from small subunit precursors in yeast.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RNA import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, small subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein kinase RIO2

NP_014192.1

EC 2.7.11.1

Essential serine kinase involved in the processing of 20S pre-rRNA; involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

255353..256630

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183045.1 → NP_014192.1 TPA: protein kinase RIO2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014192.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0Y3, P40160

UniProtKB/TrEMBL

A6ZRN3, B3LP51, B5VQK4, C7GTH5, C8ZG25, G2WLQ6, N1P447

Conserved Domains (2) summary

COG0478
Location:1 → 339

RIO2; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]

pfam04931
Location:355 → 407

DNA_pol_phi; DNA polymerase phi