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    CTS2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851977, updated on 22-Aug-2024

    Summary

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    Official Symbol
    CTS2
    Primary source
    SGD:S000002779
    Locus tag
    YDR371W
    See related
    AllianceGenome:SGD:S000002779; FungiDB:YDR371W; VEuPathDB:YDR371W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable chitin binding activity and chitinase activity. Involved in sporulation resulting in formation of a cellular spore. Located in cytoplasm. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1) and CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1219413..1220948)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Xrs2p Neighboring gene Dxo1p Neighboring gene Vps74p Neighboring gene frequenin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Ashbya gossypii cts2 mutant deficient in a sporulation-specific chitinase can be complemented by Candida albicans CHT4. Dünkler A, et al. Microbiol Res, 2008. PMID 18809304
    2. Candida albicans CHT3 encodes the functional homolog of the Cts1 chitinase of Saccharomyces cerevisiae. Dünkler A, et al. Fungal Genet Biol, 2005 Nov. PMID 16214381
    3. Sequestration of mRNAs Modulates the Timing of Translation during Meiosis in Budding Yeast. Jin L, et al. Mol Cell Biol, 2015 Oct. PMID 26217015, Free PMC Article
    4. Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Roelants FM, et al. Mol Biol Cell, 2002 Sep. PMID 12221112, Free PMC Article
    5. A conserved deubiquitinating enzyme controls cell growth by regulating RNA polymerase I stability. Richardson LA, et al. Cell Rep, 2012 Aug 30. PMID 22902402, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endochitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables exochitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polysaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative chitinase
    NP_010659.1
    • Chitinase; contains both exochitinase and endochitinase activities in vitro with higher chitobiosidase activity; glycoside hydrolase GH18 family member with putative N-terminal transmembrane domain; functionally complements A. gossypii cts2 mutant sporulation defect

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1219413..1220948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180679.1 → NP_010659.1  TPA: putative chitinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010659.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT02, Q06350
      UniProtKB/TrEMBL
      A6ZYW9, C8Z5T2, N1P723
      Conserved Domains (1) summary
      COG3325
      Location:36 → 474
      ChiA; Chitinase, GH18 family [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06350.1

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