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    GPR50 G protein-coupled receptor 50 [ Homo sapiens (human) ]

    Gene ID: 9248, updated on 3-Nov-2024

    Summary

    Official Symbol
    GPR50provided by HGNC
    Official Full Name
    G protein-coupled receptor 50provided by HGNC
    Primary source
    HGNC:HGNC:4506
    See related
    Ensembl:ENSG00000102195 MIM:300207; AllianceGenome:HGNC:4506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H9; Mel1c
    Summary
    This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GPR50 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (151176584..151182856)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (149444563..149450834)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (150345056..150349937)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:150342751-150343720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:150343721-150344689 Neighboring gene GPR50 antisense RNA 1 Neighboring gene microRNA 4330 Neighboring gene VISTA enhancer hs1746 Neighboring gene NAB1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30027 Neighboring gene vacuolar ATPase assembly factor VMA21

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC125342, AF003625.3

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables melatonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016405.2 RefSeqGene

      Range
      5001..9882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004224.3NP_004215.2  melatonin-related receptor

      See identical proteins and their annotated locations for NP_004215.2

      Status: REVIEWED

      Source sequence(s)
      BC105683, BC105684, BP245442, U52219
      Consensus CDS
      CCDS44012.1
      UniProtKB/Swiss-Prot
      Q0VGG3, Q13585, Q3ZAR0
      Related
      ENSP00000218316.3, ENST00000218316.4
      Conserved Domains (3) summary
      pfam00001
      Location:45294
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam13254
      Location:364600
      DUF4045; Domain of unknown function (DUF4045)
      cl21561
      Location:39198
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      151176584..151182856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531216.3XP_011529518.1  melatonin-related receptor isoform X1

      Conserved Domains (2) summary
      PRK14950
      Location:261344
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam00001
      Location:247
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      149444563..149450834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328118.1XP_054184093.1  melatonin-related receptor isoform X1