CRHR2 corticotropin releasing hormone receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CRHR2provided by HGNC
Official Full Name: corticotropin releasing hormone receptor 2provided by HGNC
Primary source: HGNC:HGNC:2358
See related: Ensembl:ENSG00000106113 MIM:602034; AllianceGenome:HGNC:2358
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CRF2; CRFR2; CRF-RB; HM-CRF
Summary: The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 7p14.3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (30651942..30700103, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (30789546..30837766, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (30691558..30739719, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome.
Title: Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome.
Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression.
Title: Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression.
Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia.
Title: Defects in NLRP6, autophagy and goblet cell homeostasis are associated with reduced duodenal CRH receptor 2 expression in patients with functional dyspepsia.
Association between genetic variant rs2267716 of CRHR2 gene with colorectal cancer.
Title: Association between genetic variant rs2267716 of CRHR2 gene with colorectal cancer.
Different effects of chronic social defeat on social behavior and the brain CRF system in adult male C57 mice with different susceptibilities.
Title: Different effects of chronic social defeat on social behavior and the brain CRF system in adult male C57 mice with different susceptibilities.
Dysregulation of bladder corticotropin-releasing hormone receptor in the pathogenesis of human interstitial cystitis/bladder pain syndrome.
Title: Dysregulation of bladder corticotropin-releasing hormone receptor in the pathogenesis of human interstitial cystitis/bladder pain syndrome.
DNA methylation levels within CpG sites in NR3C1, CRH, CRHR1, and CRHR2 were associated with risk for major depressive disorder across adolescence and young adulthood.
Title: DNA methylation of HPA-axis genes and the onset of major depressive disorder in adolescent girls: a prospective analysis.
The activation of CRHR1 and CRHR2 remarkably reduced the conversion of microtubules-associated protein 1 light chain 3-B (LC3B) protein, LC3BI to LC3BII and hence repressed macroautophagy/autophagy, resulting in migration inhibition.
Title: Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII.
Our results suggested that genetic variants of CRHR1 and CRHR2 genes in addition to physical negligence, and emotional and sexual abuse, contribute to increase risk of presented at least one suicide attempt
Title: Effect of CRHR1 and CRHR2 gene polymorphisms and childhood trauma in suicide attempt.
Detection of hypermethylation of CRHR2 may be promising for cancer screening in UC patients.
Title: Hypermethylation of Corticotropin Releasing Hormone Receptor-2 Gene in Ulcerative Colitis Associated Colorectal Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (73)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:4585461 (e-PCR)
- UniSTS:74520

GDB:4585185 (e-PCR)
- UniSTS:3665

RH18040 (e-PCR)
- UniSTS:27731

NoName (e-PCR)
- UniSTS:481367

D7S1538 (e-PCR)
- UniSTS:23920

AFMB050YD1 (e-PCR)
- UniSTS:59772

CRHR2__4637 (e-PCR)
- UniSTS:463250

GDB:1317464 (e-PCR)
- UniSTS:66204

ATC-P10592 (e-PCR)
- UniSTS:6302

CRHR2 (e-PCR)
- UniSTS:510380

GDB:4584951 (e-PCR)
- UniSTS:493

GDB:4585173 (e-PCR)
- UniSTS:58868

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticotrophin-releasing factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to corticotropin-releasing hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: corticotropin-releasing factor receptor 2

Names: CRH-R2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029169.1 RefSeqGene

Range

22648..53162

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202475.1 → NP_001189404.1 corticotropin-releasing factor receptor 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001189404.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains additional in-frame coding exons at the 5' end compared to variant 1, resulting in an isoform (2, also known as beta isoform) with a longer and distinct N-terminus compared to isoform 1. This receptor subtype was shown to mediate urocortin-induced MAPK activation in human myometrium (PMID:11117536).

Source sequence(s)

AC004976, AF011406, CN367944, DB308619, U34587

Consensus CDS

CCDS56478.1

UniProtKB/Swiss-Prot

Q13324

Related

ENSP00000340943.4, ENST00000348438.8

Conserved Domains (2) summary

smart00008
Location:63 → 134

HormR; Domain present in hormone receptors

pfam00002
Location:140 → 382

7tm_2; 7 transmembrane receptor (Secretin family)
NM_001202481.1 → NP_001189410.1 corticotropin-releasing factor receptor 2 isoform 3

See identical proteins and their annotated locations for NP_001189410.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains additional exons at the 5' end compared to variant 1, resulting in a shorter isoform (3, also known as gamma isoform) with a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC004976, AF011406, AF019381, CN367944, DB308619, U34587, Y10153

Consensus CDS

CCDS56477.1

UniProtKB/Swiss-Prot

Q13324

Related

ENSP00000344304.4, ENST00000341843.8

Conserved Domains (2) summary

smart00008
Location:22 → 93

HormR; Domain present in hormone receptors

pfam00002
Location:99 → 341

7tm_2; 7 transmembrane receptor (Secretin family)
NM_001202482.2 → NP_001189411.1 corticotropin-releasing factor receptor 2 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame acceptor splice site at one of the coding exons compared to variant 1, resulting in an isoform (4, also known as isoform desQ) 1 aa shorter than isoform 1.

Source sequence(s)

AC004976, AF011406, CN367944, DA808296, DB308619, EU012443, U34587

UniProtKB/Swiss-Prot

Q13324

Conserved Domains (2) summary

smart00008
Location:36 → 107

HormR; Domain present in hormone receptors

pfam00002
Location:112 → 354

7tm_2; 7 transmembrane receptor (Secretin family)
NM_001202483.2 → NP_001189412.1 corticotropin-releasing factor receptor 2 isoform 5

See identical proteins and their annotated locations for NP_001189412.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an additional exon at the penultimate position compared to variant 1, resulting in a frame-shift and a shorter isoform (5, also known as isoform D) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC004976, AK313661, CN367944, DA808296, DB308619, EU012439, U34587

Consensus CDS

CCDS75576.1

UniProtKB/Swiss-Prot

Q13324

Related

ENSP00000426498.3, ENST00000506074.6

Conserved Domains (2) summary

smart00008
Location:36 → 107

HormR; Domain present in hormone receptors

pfam00002
Location:113 → 355

7tm_2; 7 transmembrane receptor (Secretin family)
NM_001883.5 → NP_001874.2 corticotropin-releasing factor receptor 2 isoform 1

See identical proteins and their annotated locations for NP_001874.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as alpha isoform).

Source sequence(s)

AC004976, AK313661, CN367944, DA808296, DB308619, U34587

Consensus CDS

CCDS5429.1

UniProtKB/Swiss-Prot

B2R967, B3SXS6, B3SXS7, B3SXS8, B3SXT0, F8WA81, O43461, Q13324, Q4QRJ4, Q99431

UniProtKB/TrEMBL

A0A090N7T4

Related

ENSP00000418722.1, ENST00000471646.6

Conserved Domains (2) summary

smart00008
Location:36 → 107

HormR; Domain present in hormone receptors

cd15446
Location:113 → 376

7tmB1_CRF-R2; corticotropin-releasing factor receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

30651942..30700103 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047419893.1 → XP_047275849.1 corticotropin-releasing factor receptor 2 isoform X2
XM_047419892.1 → XP_047275848.1 corticotropin-releasing factor receptor 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

30789546..30837766 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054357267.1 → XP_054213242.1 corticotropin-releasing factor receptor 2 isoform X2
XM_054357266.1 → XP_054213241.1 corticotropin-releasing factor receptor 2 isoform X1