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    Ncf1 neutrophil cytosolic factor 1 [ Cavia porcellus (domestic guinea pig) ]

    Gene ID: 100726055, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Ncf1
    Gene description
    neutrophil cytosolic factor 1
    See related
    Ensembl:ENSCPOG00000000189
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cavia porcellus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
    Orthologs
    human mouse all
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    Genomic context

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    See Ncf1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947506.1 (61990671..62001332, complement)
    103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176185.1 (554979..565620, complement)

    NW_026947506.1Genomic Context describing neighboring genes Neighboring gene general transcription factor II-I repeat domain-containing protein 2B Neighboring gene RCC1 like Neighboring gene general transcription factor IIi Neighboring gene GTF2I repeat domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables superoxide-generating NADPH oxidase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in respiratory burst IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neutrophil cytosol factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mCavPor4.1

    Genomic

    1. NW_026947506.1 Reference mCavPor4.1

      Range
      61990671..62001332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013149310.3 → XP_013004764.1  neutrophil cytosol factor 1 isoform X3

      Conserved Domains (4) summary
      cd06887
      Location:6 → 123
      PX_p47phox; The phosphoinositide binding Phox Homology domain of the p47phox subunit of NADPH oxidase
      cd12022
      Location:153 → 205
      SH3_p47phox_2; Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
      pfam08944
      Location:255 → 306
      p47_phox_C; NADPH oxidase subunit p47Phox, C terminal domain
      pfam16621
      Location:205 → 254
      NECFESHC; SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1

    2. XM_004999410.4 → XP_004999467.1  neutrophil cytosol factor 1 isoform X1

      UniProtKB/TrEMBL
      H0UTD3, H0UTD4
      Related
      ENSCPOP00000000165.3
      Conserved Domains (5) summary
      cd06887
      Location:6 → 123
      PX_p47phox; The phosphoinositide binding Phox Homology domain of the p47phox subunit of NADPH oxidase
      cd12022
      Location:230 → 282
      SH3_p47phox_2; Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
      pfam08944
      Location:332 → 383
      p47_phox_C; NADPH oxidase subunit p47Phox, C terminal domain
      pfam16621
      Location:282 → 331
      NECFESHC; SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
      cl17036
      Location:160 → 212
      SH3; Src Homology 3 domain superfamily

    3. XM_013149307.2 → XP_013004761.1  neutrophil cytosol factor 1 isoform X2

      UniProtKB/TrEMBL
      H0UTD3
      Conserved Domains (5) summary
      cd12022
      Location:204 → 256
      SH3_p47phox_2; Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
      pfam08944
      Location:306 → 357
      p47_phox_C; NADPH oxidase subunit p47Phox, C terminal domain
      pfam16621
      Location:256 → 305
      NECFESHC; SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
      cl02563
      Location:1 → 97
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl17036
      Location:134 → 186
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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