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    Wnk3 WNK lysine deficient protein kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317420, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Wnk3provided by RGD
    Official Full Name
    WNK lysine deficient protein kinase 3provided by RGD
    Primary source
    RGD:1563131
    See related
    EnsemblRapid:ENSRNOG00000002537 AllianceGenome:RGD:1563131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563131
    Summary
    Predicted to enable chloride channel inhibitor activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of pancreatic juice secretion; positive regulation of peptidyl-threonine phosphorylation; and regulation of metal ion transport. Predicted to act upstream of or within maintenance of blood-brain barrier. Predicted to be located in adherens junction and bicellular tight junction. Predicted to be active in cytosol. Orthologous to human WNK3 (WNK lysine deficient protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 113.1), Brain (RPKM 55.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wnk3 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (23599278..23742290)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (20156260..20299252)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (20316081..20459245)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene TSR2, ribosome maturation factor Neighboring gene ribosomal protein S12, pseudogene Neighboring gene U1 spliceosomal RNA Neighboring gene family with sequence similarity 120 member C Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in Rats. Zhu J, et al. Neuroscience, 2021 Nov 21. PMID 34626749
    2. Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway. Wu D, et al. Exp Neurol, 2020 Oct. PMID 32589890
    3. Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway. Veríssimo F, et al. Oncogene, 2006 Jul 13. PMID 16501604
    4. LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity. Zhang Z, et al. J Biol Chem, 2013 Apr 26. PMID 23482566, Free PMC Article
    5. The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. Yang CL, et al. J Clin Invest, 2007 Nov. PMID 17975670, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in Rats.
      Title: WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in Rats.
    2. Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway.
      Title: Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway.
    3. LINGO-1 potentiates neuronal apoptosis, likely by inhibiting WNK3 kinase activity.
      Title: LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular hyperosmotic response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within maintenance of blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of pancreatic juice secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-membrane-bounded organelle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of osmosensory signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of sodium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of regulation of monoatomic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase WNK3
    NP_001157079.1
    NP_001398747.1
    XP_006256845.1
    XP_008771338.1
    XP_008771339.1
    XP_008771340.1
    XP_017457560.1
    XP_038955733.1
    XP_038955734.1
    XP_063136128.1
    XP_063136129.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163607.1 → NP_001157079.1  serine/threonine-protein kinase WNK3 isoform 2

      See identical proteins and their annotated locations for NP_001157079.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474063
      UniProtKB/TrEMBL
      A6KLA2, D4A7Z8
      Related
      ENSRNOP00000042493.3, ENSRNOT00000047444.5
      Conserved Domains (3) summary
      smart00220
      Location:151 → 404
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:135 → 409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425 → 462
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    2. NM_001411818.1 → NP_001398747.1  serine/threonine-protein kinase WNK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A1W2Q671
      Related
      ENSRNOP00000076151.2, ENSRNOT00000093675.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      23599278..23742290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280058.1 → XP_063136128.1  serine/threonine-protein kinase WNK3 isoform X4

    2. XM_039099806.2 → XP_038955734.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q671
      Conserved Domains (2) summary
      cd14031
      Location:135 → 409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425 → 488
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    3. XM_008773116.4 → XP_008771338.1  serine/threonine-protein kinase WNK3 isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:151 → 404
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:135 → 409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425 → 462
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    4. XM_017602071.3 → XP_017457560.1  serine/threonine-protein kinase WNK3 isoform X3

    5. XM_006256783.5 → XP_006256845.1  serine/threonine-protein kinase WNK3 isoform X1

      See identical proteins and their annotated locations for XP_006256845.1

      UniProtKB/TrEMBL
      A0A1W2Q671
      Conserved Domains (2) summary
      cd14031
      Location:135 → 409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425 → 488
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    6. XM_008773118.4 → XP_008771340.1  serine/threonine-protein kinase WNK3 isoform X5

      Conserved Domains (3) summary
      smart00220
      Location:151 → 404
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:135 → 409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425 → 462
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    7. XM_063280059.1 → XP_063136129.1  serine/threonine-protein kinase WNK3 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K2Y2
      Related
      ENSRNOP00000072423.2, ENSRNOT00000082177.3

    8. XM_008773117.4 → XP_008771339.1  serine/threonine-protein kinase WNK3 isoform X4

      Conserved Domains (3) summary
      smart00220
      Location:151 → 404
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:135 → 409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425 → 462
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

    9. XM_039099805.2 → XP_038955733.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q671
      Conserved Domains (2) summary
      cd14031
      Location:135 → 409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425 → 488
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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