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    Gtdc1 glycosyltransferase-like domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362129, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gtdc1provided by RGD
    Official Full Name
    glycosyltransferase-like domain containing 1provided by RGD
    Primary source
    RGD:1563393
    See related
    EnsemblRapid:ENSRNOG00000031038 AllianceGenome:RGD:1563393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    QTMAN
    Summary
    Enables tRNA-queuosine(34) beta-mannosyltransferase activity. Involved in tRNA modification. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human GTDC1 (glycosyltransferase like domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 84.1), Lung (RPKM 55.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtdc1 in Genome Data Viewer
    Location:
    3q12
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (49176110..49571594, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (28766640..29161668, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (29410426..29705981, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 15 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134486356 Neighboring gene uncharacterized LOC134486357 Neighboring gene uncharacterized LOC108350367 Neighboring gene RNA, U2 small nuclear 18 Neighboring gene zinc finger E-box binding homeobox 2 Neighboring gene ZEB2 antisense RNA 1 Neighboring gene uncharacterized LOC102548671

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Zhao X, et al. Cell, 2023 Dec 7. PMID 37992713

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-queuosine(34) beta-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA-queuosine(34) beta-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-queuosine(34) beta-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-queuosine alpha-mannosyltransferase; glycosyltransferase-like domain-containing protein 1
    Names
    glycosyltransferase-like protein
    NP_001019445.1
    NP_001380618.1
    XP_063140150.1
    XP_063140151.1
    XP_063140152.1
    XP_063140153.1
    XP_063140154.1
    XP_063140155.1
    XP_063140156.1
    XP_063140157.1
    XP_063140158.1
    XP_063140159.1
    XP_063140160.1
    XP_063140161.1
    XP_063140162.1
    XP_063140163.1
    XP_063140164.1
    XP_063140165.1
    XP_063140166.1
    XP_063140167.1
    XP_063140168.1
    XP_063140169.1
    XP_063140170.1
    XP_063140171.1
    XP_063140172.1
    XP_063140173.1
    XP_063140174.1
    XP_063140175.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024274.2 → NP_001019445.1  tRNA-queuosine alpha-mannosyltransferase isoform 2

      See identical proteins and their annotated locations for NP_001019445.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q53E76
      UniProtKB/TrEMBL
      A0A8I5ZP27
      Related
      ENSRNOP00000056430.1, ENSRNOT00000059679.3
      Conserved Domains (3) summary
      COG0438
      Location:222 → 381
      RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      pfam12038
      Location:2 → 108
      DUF3524; Domain of unknown function (DUF3524)
      cl10013
      Location:221 → 389
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    2. NM_001393689.1 → NP_001380618.1  tRNA-queuosine alpha-mannosyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZP27, A0A8I6GA65, A6JEX6
      Related
      ENSRNOP00000082987.1, ENSRNOT00000109271.2
      Conserved Domains (2) summary
      cd01635
      Location:275 → 386
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
      pfam12038
      Location:2 → 164
      DUF3524; Domain of unknown function (DUF3524)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      49176110..49571594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284086.1 → XP_063140156.1  glycosyltransferase-like domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A338
      Related
      ENSRNOP00000110521.1, ENSRNOT00000142395.1

    2. XM_063284099.1 → XP_063140169.1  glycosyltransferase-like domain-containing protein 1 isoform X13

    3. XM_063284085.1 → XP_063140155.1  glycosyltransferase-like domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A338

    4. XM_063284098.1 → XP_063140168.1  glycosyltransferase-like domain-containing protein 1 isoform X13

    5. XM_063284102.1 → XP_063140172.1  glycosyltransferase-like domain-containing protein 1 isoform X13

    6. XM_063284083.1 → XP_063140153.1  glycosyltransferase-like domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A338

    7. XM_063284090.1 → XP_063140160.1  glycosyltransferase-like domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GA65, A6JEX6

    8. XM_063284084.1 → XP_063140154.1  glycosyltransferase-like domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A338

    9. XM_063284087.1 → XP_063140157.1  glycosyltransferase-like domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A338
      Related
      ENSRNOP00000079984.2, ENSRNOT00000108792.2

    10. XM_063284091.1 → XP_063140161.1  glycosyltransferase-like domain-containing protein 1 isoform X6

    11. XM_063284080.1 → XP_063140150.1  glycosyltransferase-like domain-containing protein 1 isoform X1

    12. XM_063284092.1 → XP_063140162.1  glycosyltransferase-like domain-containing protein 1 isoform X7

    13. XM_063284081.1 → XP_063140151.1  glycosyltransferase-like domain-containing protein 1 isoform X2

      Related
      ENSRNOP00000112599.1, ENSRNOT00000143060.1

    14. XM_063284089.1 → XP_063140159.1  glycosyltransferase-like domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A338
      Related
      ENSRNOP00000103343.1, ENSRNOT00000171954.1

    15. XM_063284088.1 → XP_063140158.1  glycosyltransferase-like domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A338

    16. XM_063284101.1 → XP_063140171.1  glycosyltransferase-like domain-containing protein 1 isoform X14

    17. XM_063284100.1 → XP_063140170.1  glycosyltransferase-like domain-containing protein 1 isoform X14

    18. XM_063284095.1 → XP_063140165.1  glycosyltransferase-like domain-containing protein 1 isoform X10

    19. XM_063284096.1 → XP_063140166.1  glycosyltransferase-like domain-containing protein 1 isoform X11

    20. XM_063284082.1 → XP_063140152.1  glycosyltransferase-like domain-containing protein 1 isoform X3

    21. XM_063284093.1 → XP_063140163.1  glycosyltransferase-like domain-containing protein 1 isoform X8

    22. XM_063284097.1 → XP_063140167.1  glycosyltransferase-like domain-containing protein 1 isoform X12

    23. XM_063284094.1 → XP_063140164.1  glycosyltransferase-like domain-containing protein 1 isoform X9

    24. XM_063284104.1 → XP_063140174.1  glycosyltransferase-like domain-containing protein 1 isoform X16

    25. XM_063284105.1 → XP_063140175.1  glycosyltransferase-like domain-containing protein 1 isoform X17

    26. XM_063284103.1 → XP_063140173.1  glycosyltransferase-like domain-containing protein 1 isoform X15

    RNA

    1. XR_010064658.1 RNA Sequence

    2. XR_010064659.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53E76.1 GenPept UniProtKB/Swiss-Prot:Q53E76

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