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    Serpind1 serpin family D member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79224, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Serpind1provided by RGD
    Official Full Name
    serpin family D member 1provided by RGD
    Primary source
    RGD:619854
    See related
    EnsemblRapid:ENSRNOG00000001865 AllianceGenome:RGD:619854
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rls2var1
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in heparin cofactor II deficiency. Orthologous to human SERPIND1 (serpin family D member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 3375.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Serpind1 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97168753..97179830, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83664517..83675593, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87913814..87924880, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene synaptosome associated protein 29 Neighboring gene uncharacterized LOC134481103 Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene transmembrane protein 191C Neighboring gene HIC ZBTB transcriptional repressor 2 Neighboring gene 60S ribosomal protein L37 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular and cellular basis for type I heparin cofactor II deficiency (heparin cofactor II Awaji). Kondo S, et al. Blood, 1996 Feb 1. PMID 8562924
    2. Secondary thrombin-binding site, glycosaminoglycan binding domain and reactive center region of leuserpin-2 are strongly conserved in mammalian species. Westrup D, et al. Biochim Biophys Acta, 1994 Jan 18. PMID 8286422
    3. Plasma levels of heparin cofactor II (HCII) and thrombin-HCII complex in patients with disseminated intravascular coagulation. Noda A, et al. Clin Appl Thromb Hemost, 2002 Jul. PMID 12361205
    4. A novel missense mutation in the human plasmin inhibitor (alpha2-antiplasmin) gene associated with a bleeding tendency. Lind B, et al. Br J Haematol, 1999 Nov. PMID 10583218
    5. Inhibitors of fibrinolysis are elevated in atherosclerotic plaque. Robbie LA, et al. Arterioscler Thromb Vasc Biol, 1996 Apr. PMID 8624776

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heparin cofactor 2
    Names
    HC-II
    heparin cofactor II
    leuserpin 2
    protease inhibitor leuserpin-2
    serine (or cysteine) peptidase inhibitor, clade D, member 1
    serine (or cysteine) proteinase inhibitor, clade D, member 1
    serpin D1
    serpin peptidase inhibitor, clade D (heparin cofactor), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024382.1 → NP_077358.1  heparin cofactor 2 precursor

      See identical proteins and their annotated locations for NP_077358.1

      Status: PROVISIONAL

      Source sequence(s)
      X74549
      UniProtKB/Swiss-Prot
      Q5BKA6, Q64268
      UniProtKB/TrEMBL
      A0A0G2K8K3, A6JSM3
      Related
      ENSRNOP00000031829.4, ENSRNOT00000031819.7
      Conserved Domains (1) summary
      cd02047
      Location:44 → 477
      HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      97168753..97179830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248709.4 → XP_006248771.1  heparin cofactor 2 isoform X1

      See identical proteins and their annotated locations for XP_006248771.1

      UniProtKB/Swiss-Prot
      Q5BKA6, Q64268
      UniProtKB/TrEMBL
      A0A0G2K8K3, A6JSM3
      Related
      ENSRNOP00000074639.2, ENSRNOT00000084973.3
      Conserved Domains (1) summary
      cd02047
      Location:44 → 477
      HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64268.1 GenPept UniProtKB/Swiss-Prot:Q64268

    Gene LinkOut

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