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    Glyat glycine-N-acyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293779, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Glyatprovided by RGD
    Official Full Name
    glycine-N-acyltransferaseprovided by RGD
    Primary source
    RGD:1307163
    See related
    EnsemblRapid:ENSRNOG00000012142 AllianceGenome:RGD:1307163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glycine N-acyltransferase activity and glycine N-benzoyltransferase activity. Predicted to be involved in benzoyl-CoA metabolic process; glycine metabolic process; and monocarboxylic acid metabolic process. Predicted to be active in mitochondrion. Orthologous to human GLYAT (glycine-N-acyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 2161.8) See more
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    Genomic context

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    See Glyat in Genome Data Viewer
    Location:
    1q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (219128798..219149615)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (209704213..209724949)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (229060125..229081113)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene glycine-N-acyltransferase-like 1 Neighboring gene olfactory receptor family 5 subfamily B member 95 like 1 Neighboring gene olfactory receptor family 5 subfamily B member 95

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enhanced phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies. Wen H, et al. Mol Cell Proteomics, 2013 Mar. PMID 23230277, Free PMC Article
    2. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. Matsuo M, et al. Biochem Biophys Res Commun, 2012 Apr 20. PMID 22475485
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93750

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glycine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine N-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycine N-benzoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine N-benzoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine N-benzoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycine N-benzoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in benzoyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in benzoyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monocarboxylic acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glycine N-acyltransferase
    Names
    AAc
    acyl-CoA:glycine N-acyltransferase
    aralkyl acyl-CoA N-acyltransferase
    aralkyl acyl-CoA:amino acid N-acyltransferase
    benzoyl-coenzyme A:glycine N-acyltransferase
    glycine N-benzoyltransferase
    liver regeneration-related protein LRRG067
    NP_001009648.1
    NP_001399482.1
    XP_038964631.1
    XP_038964632.1
    XP_063143048.1
    XP_063143049.1
    XP_063143050.1
    XP_063143052.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009648.3 → NP_001009648.1  glycine N-acyltransferase

      See identical proteins and their annotated locations for NP_001009648.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5PQT3, Q7TP56
      UniProtKB/TrEMBL
      A0A0G2JWI5, A4PB92
      Conserved Domains (2) summary
      pfam08444
      Location:207 → 295
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 206
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    2. NM_001412553.1 → NP_001399482.1  glycine N-acyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5PQT3, Q7TP56
      UniProtKB/TrEMBL
      A4PB92
      Related
      ENSRNOP00000069894.1, ENSRNOT00000087526.3

    RNA

    1. NR_178215.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      219128798..219149615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286978.1 → XP_063143048.1  glycine N-acyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q5PQT3, Q7TP56
      UniProtKB/TrEMBL
      A4PB92

    2. XM_063286980.1 → XP_063143050.1  glycine N-acyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q5PQT3, Q7TP56
      UniProtKB/TrEMBL
      A4PB92

    3. XM_063286979.1 → XP_063143049.1  glycine N-acyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q5PQT3, Q7TP56
      UniProtKB/TrEMBL
      A4PB92
      Related
      ENSRNOP00000016454.3, ENSRNOT00000016454.7

    4. XM_063286982.1 → XP_063143052.1  glycine N-acyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q5PQT3, Q7TP56
      UniProtKB/TrEMBL
      A4PB92

    5. XM_039108703.2 → XP_038964631.1  glycine N-acyltransferase isoform X2

      Conserved Domains (2) summary
      pfam08444
      Location:143 → 231
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 142
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

    6. XM_039108704.2 → XP_038964632.1  glycine N-acyltransferase isoform X2

      Conserved Domains (2) summary
      pfam08444
      Location:143 → 231
      Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
      pfam06021
      Location:1 → 142
      Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQT3.1 GenPept UniProtKB/Swiss-Prot:Q5PQT3

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