Sox6 SRY-box transcription factor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Sox6provided by RGD
Full Name: SRY-box transcription factor 6provided by RGD
Primary source: RGD:1309000
See related: EnsemblRapid:ENSRNOG00000020514 AllianceGenome:RGD:1309000
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cis-regulatory region sequence-specific DNA binding activity. Involved in astrocyte differentiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human SOX6 (SRY-box transcription factor 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 95.6), Kidney (RPKM 44.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (179157678..179769243, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (169723306..170334846, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (185631702..186186192)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA Gm4419 induces cell apoptosis in hepatic ischemia-reperfusion injury via regulating the miR-455-SOX6 axis.
Title: LncRNA Gm4419 induces cell apoptosis in hepatic ischemia-reperfusion injury via regulating the miR-455-SOX6 axis.
The authors proved that miR-499-5p inhibited hypoxia/reoxygenation-induced cardiomyocytes injury by targeting SOX6.
Title: MiR-499 inhibited hypoxia/reoxygenation induced cardiomyocytes injury by targeting SOX6.
Study revealed that Sox5 and Sox6 prevent oligodendroglial differentiation, thus ensuring that the progenitor cells first reach their proper destination and only then lose their migratory capacity
Title: Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain.
The apoptosis process enhanced by overexpression of SOX6 or PDCD4, was rescued by the cardiac-abundant miR-499 in rat cardiomyocytes.
Title: SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition.
a spatially loaded combination of RUNX2 and SOX trio DNA loading significantly improved healing relative to empty hydrogels or either factor alone.
Title: Osteochondral tissue regeneration through polymeric delivery of DNA encoding for the SOX trio and RUNX2.
Local adipose tissue stem cells protected the bronchial stump after pneumonectomy and induced local changes in Sox6 gene expression.
Title: Stem cells protect the bronchial stump in rat, increasing Sox6, Col2a1, and Agc1 expression.
Cdk5 regulates Sox6 steady state protein level that has an important role in brain development and function
Title: Regulation of Sox6 by cyclin dependent kinase 5 in brain.
The gene expressions of SOX-5, -6, -9 decreased by 58, 20 and 40%, respectively, in the osteoarthritis cartilage, while their respective protein expressions increased.
Title: The expressions of the SOX trio, PTHrP (parathyroid hormone-related peptide)/IHH (Indian hedgehog protein) in surgically induced osteoarthritis of the rat.
Data show that a Sox6 3'-UTR reporter gene confirmed Sox6 is a target gene of miR-499.
Title: Evidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophy.
In mutant rats containing a mutation here, glucose-stimulated insul secretion is impaired.
Title: Mutation of the Pax6 gene causes impaired glucose-stimulated insulin secretion.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Rat281 (e-PCR), detects polymorphism
- UniSTS:227095

U32614 (e-PCR)
- UniSTS:125723

Sox6 (e-PCR), detects polymorphism
- UniSTS:144490

UniSTS:144491 (e-PCR)
- UniSTS:144491

Sox6 (e-PCR), detects polymorphism
- UniSTS:144491

STS-H69535 (e-PCR)
- UniSTS:62663

Sox6 (e-PCR), detects polymorphism
- UniSTS:536549

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cartilage condensation	ISO Inferred from Sequence Orthology more info
involved_in cartilage condensation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte cell fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cartilage development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mesenchymal stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spinal cord oligodendrocyte cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transcription factor SOX-6

Names: SRY (sex determining region Y)-box 6; SRY box 6; SRY-box containing gene 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024751.1 → NP_001019922.1 transcription factor SOX-6

See identical proteins and their annotated locations for NP_001019922.1

Status: PROVISIONAL

Source sequence(s)

BC097403

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A6I8C8

Related

ENSRNOP00000079879.1, ENSRNOT00000094350.2

Conserved Domains (1) summary

cd01388
Location:579 → 650

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

179157678..179769243 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039106334.2 → XP_038962262.1 transcription factor SOX-6 isoform X5

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_063285244.1 → XP_063141314.1 transcription factor SOX-6 isoform X5

UniProtKB/TrEMBL

A0A6I8PLH1
XM_063285274.1 → XP_063141344.1 transcription factor SOX-6 isoform X5

UniProtKB/TrEMBL

A0A6I8PLH1
XM_039106327.2 → XP_038962255.1 transcription factor SOX-6 isoform X5

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_063285251.1 → XP_063141321.1 transcription factor SOX-6 isoform X5

UniProtKB/TrEMBL

A0A6I8PLH1
XM_063285245.1 → XP_063141315.1 transcription factor SOX-6 isoform X5

UniProtKB/TrEMBL

A0A6I8PLH1
XM_039106354.2 → XP_038962282.1 transcription factor SOX-6 isoform X5

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_063285282.1 → XP_063141352.1 transcription factor SOX-6 isoform X5

UniProtKB/TrEMBL

A0A6I8PLH1
XM_063285278.1 → XP_063141348.1 transcription factor SOX-6 isoform X5

UniProtKB/TrEMBL

A0A6I8PLH1
XM_039106338.2 → XP_038962266.1 transcription factor SOX-6 isoform X5

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_039106363.2 → XP_038962291.1 transcription factor SOX-6 isoform X5

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_039106343.2 → XP_038962271.1 transcription factor SOX-6 isoform X5

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_063285281.1 → XP_063141351.1 transcription factor SOX-6 isoform X5

UniProtKB/TrEMBL

A0A6I8PLH1
XM_039106328.1 → XP_038962256.1 transcription factor SOX-6 isoform X5

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Related

ENSRNOP00000044088.4, ENSRNOT00000048020.6

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_039106374.2 → XP_038962302.1 transcription factor SOX-6 isoform X5

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_063285283.1 → XP_063141353.1 transcription factor SOX-6 isoform X5

UniProtKB/TrEMBL

A0A6I8PLH1
XM_063285280.1 → XP_063141350.1 transcription factor SOX-6 isoform X5

UniProtKB/TrEMBL

A0A6I8PLH1
XM_039106360.2 → XP_038962288.1 transcription factor SOX-6 isoform X5

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_063285275.1 → XP_063141345.1 transcription factor SOX-6 isoform X5

UniProtKB/TrEMBL

A0A6I8PLH1
XM_039106377.2 → XP_038962305.1 transcription factor SOX-6 isoform X5

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006230091.5 → XP_006230153.1 transcription factor SOX-6 isoform X5

See identical proteins and their annotated locations for XP_006230153.1

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_039106304.2 → XP_038962232.1 transcription factor SOX-6 isoform X3

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A6I8C8

Conserved Domains (1) summary

cd01388
Location:627 → 698

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_039106313.2 → XP_038962241.1 transcription factor SOX-6 isoform X4

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A6I8C8

Conserved Domains (1) summary

cd01388
Location:626 → 697

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_039106301.2 → XP_038962229.1 transcription factor SOX-6 isoform X1

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A6I8C8

Related

ENSRNOP00000068898.3, ENSRNOT00000079072.3

Conserved Domains (1) summary

cd01388
Location:647 → 718

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
XM_006230087.5 → XP_006230149.1 transcription factor SOX-6 isoform X2

See identical proteins and their annotated locations for XP_006230149.1

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A6I8C8

Conserved Domains (1) summary

cd01388
Location:646 → 717

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
XM_006230094.5 → XP_006230156.1 transcription factor SOX-6 isoform X8

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A6I8C8

Conserved Domains (1) summary

cd01388
Location:585 → 656

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
XM_006230092.5 → XP_006230154.1 transcription factor SOX-6 isoform X6

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A6I8C8

Conserved Domains (1) summary

cd01388
Location:606 → 677

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
XM_006230093.5 → XP_006230155.1 transcription factor SOX-6 isoform X7

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6R0V8A0, A6I8C8

Conserved Domains (1) summary

cd01388
Location:605 → 676

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
XM_017588968.3 → XP_017444457.1 transcription factor SOX-6 isoform X5

UniProtKB/Swiss-Prot

A0A0G2JTZ2, F1MAJ5, Q4V8G3

UniProtKB/TrEMBL

A0A6I8PLH1, A6I8C8

Conserved Domains (1) summary

cd01388
Location:620 → 691

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...