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    Pm20d1 peptidase M20 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 212933, updated on 2-Nov-2024

    Summary

    Official Symbol
    Pm20d1provided by MGI
    Official Full Name
    peptidase M20 domain containing 1provided by MGI
    Primary source
    MGI:MGI:2442939
    See related
    Ensembl:ENSMUSG00000042251 AllianceGenome:MGI:2442939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732466D17Rik
    Summary
    Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including adaptive thermogenesis; amide catabolic process; and energy homeostasis. Located in extracellular space. Is expressed in embryo; embryo endoderm; and notochord. Orthologous to human PM20D1 (peptidase M20 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 26.9), large intestine adult (RPKM 13.8) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Pm20d1 in Genome Data Viewer
    Location:
    1 E4; 1 57.19 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131725122..131749210)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131797385..131821472)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30104 Neighboring gene solute carrier family 26, member 9 Neighboring gene STARR-seq mESC enhancer starr_02224 Neighboring gene STARR-seq mESC enhancer starr_02225 Neighboring gene STARR-positive B cell enhancer ABC_E8960 Neighboring gene solute carrier family 41, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E5799 Neighboring gene RAB29, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC159098

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in adaptive thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in amide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in amide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in amino acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amino acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    N-fatty-acyl-amino acid synthase/hydrolase PM20D1
    Names
    peptidase M20 domain-containing protein 1
    probable carboxypeptidase PM20D1
    NP_001344407.1
    NP_835180.2
    XP_006529402.1
    XP_011246269.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357478.1NP_001344407.1  N-fatty-acyl-amino acid synthase/hydrolase PM20D1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161805, AK028883
      Consensus CDS
      CCDS15274.1
      UniProtKB/Swiss-Prot
      Q3UNX0, Q8C165, Q8R117
      Related
      ENSMUSP00000046079.6, ENSMUST00000048660.12
      Conserved Domains (1) summary
      cd05674
      Location:53488
      M20_yscS; M20 Peptidase, carboxypeptidase yscS
    2. NM_178079.3NP_835180.2  N-fatty-acyl-amino acid synthase/hydrolase PM20D1 precursor

      See identical proteins and their annotated locations for NP_835180.2

      Status: VALIDATED

      Source sequence(s)
      AC161805
      Consensus CDS
      CCDS15274.1
      UniProtKB/Swiss-Prot
      Q3UNX0, Q8C165, Q8R117
      Related
      ENSMUSP00000108012.3, ENSMUST00000112393.9
      Conserved Domains (1) summary
      cd05674
      Location:53488
      M20_yscS; M20 Peptidase, carboxypeptidase yscS

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131725122..131749210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247967.4XP_011246269.1  N-fatty-acyl-amino acid synthase/hydrolase PM20D1 isoform X1

      Conserved Domains (1) summary
      cd05674
      Location:53463
      M20_yscS; M20 Peptidase, carboxypeptidase yscS
    2. XM_006529339.2XP_006529402.1  N-fatty-acyl-amino acid synthase/hydrolase PM20D1 isoform X2

      Conserved Domains (1) summary
      cd05674
      Location:53463
      M20_yscS; M20 Peptidase, carboxypeptidase yscS