MIR487B microRNA 487b [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR487Bprovided by HGNC
Official Full Name: microRNA 487bprovided by HGNC
Primary source: HGNC:HGNC:32533
See related: Ensembl:ENSG00000207754 MIM:615037; miRBase:MI0003530; AllianceGenome:HGNC:32533
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN487B; mir-487b
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 14q32.31

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (101046455..101046538)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (95281832..95281915)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (101512792..101512875)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-487b suppressed inflammation and neuronal apoptosis in spinal cord injury by targeted Ifitm3.
Title: MiR-487b suppressed inflammation and neuronal apoptosis in spinal cord injury by targeted Ifitm3.
Increased miR-21-3p and miR-487b-3p serum levels during anaphylactic reaction in food allergic children.
Title: Increased miR-21-3p and miR-487b-3p serum levels during anaphylactic reaction in food allergic children.
Clinical significance of serum miR-487b in HBV-related hepatocellular carcinoma and its potential mechanism.
Title: Clinical significance of serum miR-487b in HBV-related hepatocellular carcinoma and its potential mechanism.
MicroRNA487b3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3.
Title: MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3.
miR-487b and TRAK2 that form an axis to regulate the aggressiveness of osteosarcoma, are potential therapeutic targets and prognostic biomarkers.
Title: miR-487b and TRAK2 that form an axis to regulate the aggressiveness of osteosarcoma, are potential therapeutic targets and prognostic biomarkers.
miR-154-3p and miR-487-3p synergistically modulate RHOA signaling in the carcinogenesis of thyroid cancer.
Title: miR-154-3p and miR-487-3p synergistically modulate RHOA signaling in the carcinogenesis of thyroid cancer.
we confirmed that miR-487b is a CRC suppressor that prevents the EMT process and targets MYC, SUZ12, and KRAS to inhibit the proliferation, migration and invasion of CRC cells. Meanwhile, miR-487b is negatively regulated by DNA methylation
Title: DNA methylation-regulated and tumor-suppressive roles of miR-487b in colorectal cancer via targeting MYC, SUZ12, and KRAS.
miR-487b can significantly mitigate the symptoms of allergic rhinitis by inhibiting the IL-33/ST2 signaling pathway.
Title: miR-487b mitigates allergic rhinitis through inhibition of the IL-33/ST2 signaling pathway.
In human primary cells, we confirmed the shift in miR487b targeting after editing, resulting in a edited miR487b targetome that is enriched for multiple proangiogenic pathways. miR487b is found in multiple human primary vascular cell types. The same adenosine residue is methylated in mice and human primary cells.
Title: Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes Neovascularization.
The cluster 14q32.31 member miR-487b was variably under-expressed in pediatric glioma lines compared with human neural stem cells. Overexpression of miR-487b in a pediatric glioma cell line (KNS42) using lentiviral vectors led to a decrease in colony formation in soft agar (30%) (P<0.05), and decreased expression of known predicted targets PROM1 and Nestin
Title: MicroRNA profiling of low-grade glial and glioneuronal tumors shows an independent role for cluster 14q32.31 member miR-487b.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables mRNA base-pairing translational repressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of artery morphogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of vascular endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.