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    Usp26 ubiquitin specific peptidase 26 [ Mus musculus (house mouse) ]

    Gene ID: 83563, updated on 12-Nov-2024

    Summary

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    Official Symbol
    Usp26provided by MGI
    Official Full Name
    ubiquitin specific peptidase 26provided by MGI
    Primary source
    MGI:MGI:1933247
    See related
    Ensembl:ENSMUSG00000055780 AllianceGenome:MGI:1933247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm and sperm flagellum. Predicted to be active in cytosol and nucleus. Is expressed in testis. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 6. Orthologous to human USP26 (ubiquitin specific peptidase 26). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Usp26 in Genome Data Viewer
    Location:
    X A5; X 28.31 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (50841544..50890110, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (51752667..51801233, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 57669 Neighboring gene STARR-seq mESC enhancer starr_47162 Neighboring gene heparan sulfate 6-O-sulfotransferase 2 Neighboring gene STARR-seq mESC enhancer starr_47163 Neighboring gene STARR-seq mESC enhancer starr_47164 Neighboring gene predicted gene, 35727 Neighboring gene STARR-seq mESC enhancer starr_47165 Neighboring gene predicted gene, 22539 Neighboring gene STARR-seq mESC enhancer starr_47166 Neighboring gene MAGE family member A14 Neighboring gene predicted gene, 35790

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Localization of ubiquitin specific protease 26 at blood-testis barrier and near Sertoli cell-germ cell interface in mouse testes. Lin YW, et al. Int J Androl, 2011 Oct. PMID 21449984
    2. The osteoprotective role of USP26 in coordinating bone formation and resorption. Li C, et al. Cell Death Differ, 2022 Jun. PMID 35091692, Free PMC Article
    3. Usp26 mutation in mice leads to defective spermatogenesis depending on genetic background. Sakai K, et al. Sci Rep, 2019 Sep 24. PMID 31551464, Free PMC Article
    4. Disruption of ubiquitin specific protease 26 gene causes male subfertility associated with spermatogenesis defects in mice†. Tian H, et al. Biol Reprod, 2019 Apr 1. PMID 30561524, Free PMC Article
    5. USP26 deubiquitinates androgen receptor (AR) in the maintenance of sperm maturation and spermatogenesis through the androgen receptor signaling pathway. Wang J, et al. Adv Clin Exp Med, 2020 Oct. PMID 33064378

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling.
      Title: USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling.
    2. An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations.
      Title: An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations.
    3. The osteoprotective role of USP26 in coordinating bone formation and resorption.
      Title: The osteoprotective role of USP26 in coordinating bone formation and resorption.
    4. Ubiquitin-Specific Protease 29 Exacerbates Cerebral Ischemia-Reperfusion Injury in Mice.
      Title: Ubiquitin-Specific Protease 29 Exacerbates Cerebral Ischemia-Reperfusion Injury in Mice.
    5. Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.
      Title: Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.
    6. Usp26 mutation in mice leads to defective spermatogenesis depending on genetic background.
      Title: Usp26 mutation in mice leads to defective spermatogenesis depending on genetic background.
    7. Germ-cell-specific sex-linked genes, like Usp26, are subject to meiotic sex-chromosome inactivation (MSCI) during spermatogenesis.
      Title: Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse.
    8. Usp26 is a testis-specific gene identified in a genome-wide cDNA subtraction screen.
      Title: An abundance of X-linked genes expressed in spermatogonia.
    9. The loss of Usp26 affects spermatogenesis and hormone secretion and causes male subfertility. This study also provides the evidence on the interactions between USP26 and androgen receptor in mouse testis, whereby pointing to a potential mechanism.
      Title: Disruption of ubiquitin specific protease 26 gene causes male subfertility associated with spermatogenesis defects in mice†.
    10. RT-PCR assays detected the expression of Usp26 in germ cells, but not in primary Sertoli cell lines
      Title: Localization of ubiquitin specific protease 26 at blood-testis barrier and near Sertoli cell-germ cell interface in mouse testes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159157

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K48-linked deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of androgen receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 26
    Names
    deubiquitinating enzyme 26
    ubiquitin specific protease 26
    ubiquitin thioesterase 26
    ubiquitin thiolesterase 26
    ubiquitin-specific-processing protease 26
    NP_113565.2
    XP_017174134.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031388.2 → NP_113565.2  ubiquitin carboxyl-terminal hydrolase 26

      See identical proteins and their annotated locations for NP_113565.2

      Status: VALIDATED

      Source sequence(s)
      AK133417, AL662931
      Consensus CDS
      CCDS30122.1
      UniProtKB/Swiss-Prot
      Q05A11, Q99MX1
      Related
      ENSMUSP00000110519.2, ENSMUST00000114869.8
      Conserved Domains (3) summary
      cd02257
      Location:747 → 814
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:287 → 553
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      50841544..50890110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318645.1 → XP_017174134.1  ubiquitin carboxyl-terminal hydrolase 26 isoform X1

      UniProtKB/Swiss-Prot
      Q05A11, Q99MX1
      Related
      ENSMUSP00000069140.4, ENSMUST00000069509.4
      Conserved Domains (3) summary
      cd02257
      Location:747 → 814
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:287 → 553
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MX1.2 GenPept UniProtKB/Swiss-Prot:Q99MX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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