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    F13a1 coagulation factor XIII, A1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 74145, updated on 28-Oct-2024

    Summary

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    Official Symbol
    F13a1provided by MGI
    Official Full Name
    coagulation factor XIII, A1 subunitprovided by MGI
    Primary source
    MGI:MGI:1921395
    See related
    Ensembl:ENSMUSG00000039109 AllianceGenome:MGI:1921395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F13a; 1200014I03Rik
    Summary
    This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in bladder adult (RPKM 12.1), mammary gland adult (RPKM 11.7) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See F13a1 in Genome Data Viewer
    Location:
    13 A3.3; 13 14.44 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (37051150..37234220, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (36867178..37050244, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38636 Neighboring gene predicted gene, 30177 Neighboring gene neuritin 1 Neighboring gene STARR-seq mESC enhancer starr_34196 Neighboring gene predicted gene, 30489 Neighboring gene STARR-seq mESC enhancer starr_34198 Neighboring gene STARR-seq mESC enhancer starr_34199 Neighboring gene STARR-seq mESC enhancer starr_34200 Neighboring gene predicted gene, 30240 Neighboring gene STARR-seq mESC enhancer starr_34201 Neighboring gene predicted gene, 30549 Neighboring gene Rho GTPase activating protein 20 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction. Nahrendorf M, et al. Circulation, 2006 Mar 7. PMID 16505171, Free PMC Article
    2. Factor XIII Transglutaminase Supports the Resolution of Mucosal Damage in Experimental Colitis. Andersson C, et al. PLoS One, 2015. PMID 26098308, Free PMC Article
    3. Local activation of coagulation factor XIII reduces systemic complications and improves the survival of mice after Streptococcus pyogenes M1 skin infection. Deicke C, et al. Int J Med Microbiol, 2016 Nov. PMID 27338836
    4. The combined benefits of motorcycle antilock braking systems (ABS) in preventing crashes and reducing crash severity. Rizzi M, et al. Traffic Inj Prev, 2016. PMID 26098303
    5. Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Nahrendorf M, et al. Circ Res, 2007 Apr 27. PMID 17379832

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.
      Title: Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.
    2. Mast cell-derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections.
      Title: Mast cell-derived factor XIIIA contributes to sexual dimorphic defense against group B streptococcal infections.
    3. Elimination of fibrin gamma-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.
      Title: Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.
    4. Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
      Title: Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
    5. Assessment of expression and specific activities of transglutaminases TG1, TG2, and FXIII-A during osteoclastogenesis.
      Title: Assessment of expression and specific activities of transglutaminases TG1, TG2, and FXIII-A during osteoclastogenesis.
    6. Factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
      Title: Transglutaminases factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
    7. Suggest that resident macrophages maintain plasma FXIII-A and exclude the platelet lineage as a major contributor.
      Title: Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.
    8. These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations.
      Title: The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits.
    9. Mast cells have the ability to produce and degrade FXIIIA depending on their chymase expression profile: mast cells expressing chymase degrade FXIIIA, whereas mast cells that do not express chymase mainly produce FXIIIA
      Title: Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.
    10. A lack of factor XIII leads to prolonged clotting times, increased signs of inflammation, and elevated bacterial dissemination in streptococcal skin diseases.
      Title: Local activation of coagulation factor XIII reduces systemic complications and improves the survival of mice after Streptococcus pyogenes M1 skin infection.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-glutamine gamma-glutamyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in blood coagulation, fibrin clot formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blood coagulation, fibrin clot formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in blood coagulation, fibrin clot formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blood coagulation, fibrin clot formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within peptide cross-linking IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide cross-linking ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coagulation factor XIII A chain
    Names
    coagulation factor XIII, alpha subunit
    coagulation factor XIIIa
    protein-glutamine gamma-glutamyltransferase A chain
    transglutaminase A chain
    NP_001159863.1
    NP_083060.2
    XP_036014090.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166391.1 → NP_001159863.1  coagulation factor XIII A chain

      See identical proteins and their annotated locations for NP_001159863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK030914, AK049092, AV249730, BM239113
      Consensus CDS
      CCDS26456.1
      UniProtKB/Swiss-Prot
      Q3TNF9, Q8BH61, Q8BIP2
      UniProtKB/TrEMBL
      Q3V3W7
      Related
      ENSMUSP00000128316.2, ENSMUST00000164727.8
      Conserved Domains (4) summary
      smart00460
      Location:309 → 400
      TGc; Transglutaminase/protease-like homologues
      COG1305
      Location:280 → 408
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam00868
      Location:47 → 164
      Transglut_N; Transglutaminase family
      pfam00927
      Location:519 → 623
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    2. NM_028784.3 → NP_083060.2  coagulation factor XIII A chain

      See identical proteins and their annotated locations for NP_083060.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK049092, AV249730, BM239113
      Consensus CDS
      CCDS26456.1
      UniProtKB/Swiss-Prot
      Q3TNF9, Q8BH61, Q8BIP2
      UniProtKB/TrEMBL
      Q3V3W7
      Related
      ENSMUSP00000048667.9, ENSMUST00000037491.11
      Conserved Domains (4) summary
      smart00460
      Location:309 → 400
      TGc; Transglutaminase/protease-like homologues
      COG1305
      Location:280 → 408
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam00868
      Location:47 → 164
      Transglut_N; Transglutaminase family
      pfam00927
      Location:519 → 623
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      37051150..37234220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158197.1 → XP_036014090.1  coagulation factor XIII A chain isoform X1

      Conserved Domains (2) summary
      smart00460
      Location:67 → 158
      TGc; Transglutaminase/protease-like homologues
      pfam00927
      Location:277 → 381
      Transglut_C; Transglutaminase family, C-terminal ig like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH61.3 GenPept UniProtKB/Swiss-Prot:Q8BH61

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