U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    PLA2G4A phospholipase A2 group IVA [ Bos taurus (domestic cattle) ]

    Gene ID: 525072, updated on 10-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PLA2G4Aprovided by VGNC
    Official Full Name
    phospholipase A2 group IVAprovided by VGNC
    Primary source
    VGNC:VGNC:32960
    See related
    BGD:BT16529; Ensembl:ENSBTAG00000013298
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Note: GeneID 525072 and 100850818 are annotated independently on Btau_4.6.1, but may be redundant. [17 Jun 2014]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PLA2G4A in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (67907024..68081280)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene histone H2B type 1-C/E/F/G/I-like Neighboring gene prostaglandin-endoperoxide synthase 2 Neighboring gene potassium two pore domain channel subfamily K member 2 Neighboring gene transfer RNA valine (anticodon CAC) Neighboring gene cysteine dioxygenase type 1-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of a 42-kDa Group IV cPLA2-activating protein, cPLAPγ, as a GTP-binding protein in the bovine brain. Bach JH, et al. J Biochem, 2011 Oct. PMID 21613292
    2. Expression of phospholipase A2 group IVA (PLA2G4A) is upregulated by human chorionic gonadotropin in bovine granulosa cells of ovulatory follicles. Diouf MN, et al. Biol Reprod, 2006 Jun. PMID 16510840
    3. Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation. Gluck N, et al. Am J Physiol Cell Physiol, 2008 Jun. PMID 18385289
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. result suggests that cPLAPgamma may act as a G protein, activating cPLA(2)alpha prior to reaching full intracellular Ca(2 ) concentrations
      Title: Identification of a 42-kDa Group IV cPLA2-activating protein, cPLAPγ, as a GTP-binding protein in the bovine brain.
    2. Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation.
      Title: Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin-induced smooth muscle cell proliferation.
    3. Ovulation is associated with an LH/hCG-dependent induction of PLA2G4A in GC via the adenylyl cyclase/cAMP pathway.
      Title: Expression of phospholipase A2 group IVA (PLA2G4A) is upregulated by human chorionic gonadotropin in bovine granulosa cells of ovulatory follicles.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycerophospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytosolic phospholipase A2
    Names
    cPLA2
    phospholipase A2, group IVA (cytosolic, calcium-dependent)
    NP_001069332.1
    XP_059731388.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075864.1 → NP_001069332.1  cytosolic phospholipase A2

      See identical proteins and their annotated locations for NP_001069332.1

      Status: PROVISIONAL

      Source sequence(s)
      AY363688
      UniProtKB/TrEMBL
      A0AAF6ZS38
      Related
      ENSBTAP00000017685.3, ENSBTAT00000017685.5
      Conserved Domains (3) summary
      cd07200
      Location:144 → 730
      cPLA2_Grp-IVA; Group IVA cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:20 → 138
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      smart00022
      Location:117 → 669
      PLAc; Cytoplasmic phospholipase A2, catalytic subunit

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      67907024..68081280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059875405.1 → XP_059731388.1  cytosolic phospholipase A2 isoform X1

      UniProtKB/Swiss-Prot
      A4IFJ5, Q1XD55
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4IFJ5.1 GenPept UniProtKB/Swiss-Prot:A4IFJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.