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    ARMC10 armadillo repeat containing 10 [ Homo sapiens (human) ]

    Gene ID: 83787, updated on 7-Apr-2024

    Summary

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    Official Symbol
    ARMC10provided by HGNC
    Official Full Name
    armadillo repeat containing 10provided by HGNC
    Primary source
    HGNC:HGNC:21706
    See related
    Ensembl:ENSG00000170632 MIM:611864; AllianceGenome:HGNC:21706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SVH; PNAS112; PNAS-112; PSEC0198
    Summary
    This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 11.8), adrenal (RPKM 9.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7q22.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (103075140..103099759)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (104390254..104414903)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102715587..102740206)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:102580673-102581173 Neighboring gene leucine rich repeat containing 17 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:102584236-102584801 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:102613398-102614597 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:102616989-102617150 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:102631963-102633162 Neighboring gene nuclear factor, erythroid 4 Neighboring gene Sharpr-MPRA regulatory region 7515 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102746161-102747030 Neighboring gene crystallin zeta pseudogene 1 Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene uncharacterized LOC105375434 Neighboring gene ribosomal protein L19 pseudogene 12 Neighboring gene ribosomal protein L23a pseudogene 95

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Chen Z, et al. Nat Commun, 2019 Jan 10. PMID 30631047, Free PMC Article
    2. A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas. Huang R, et al. Cancer Res, 2003 Jul 1. PMID 12839973
    3. SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53. Zhou X, et al. FEBS Lett, 2007 Oct 16. PMID 17904127
    4. Lineage-specific gene duplication and loss in human and great ape evolution. Fortna A, et al. PLoS Biol, 2004 Jul. PMID 15252450, Free PMC Article
    5. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. Dall'Era MA, et al. Prostate, 2007 May 15. PMID 17342744

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC-derived sensory neurons.
      Title: The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC-derived sensory neurons.
    2. Data show that the serine S45 site of armadillo repeat containing 10 (ARMC10) can be phosphorylated by AMP-activated protein kinase (AMPK) both in vitro and in vivo. .
      Title: Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. a novel gene SVH, up-regulated in hepatocellular carcinoma, was identified; four variants SVH-A, -B, -C, and -D, resulting from alternative splicing in the coding region of the SVH transcript, were observed and localized in the endoplasmic reticulum
      Title: A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3195, FLJ37850

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat-containing protein 10
    Names
    specific splicing variant involved in hepatocarcinogenesis
    splicing variant involved in hepatocarcinogenesis protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030014.1 RefSeqGene

      Range
      5260..29879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161009.3 → NP_001154481.1  armadillo repeat-containing protein 10 isoform b

      See identical proteins and their annotated locations for NP_001154481.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) lacks an in-frame exon in the 5' coding region compared to variant A. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AI761577, AY150851, AY150853, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS55146.1
      UniProtKB/Swiss-Prot
      Q8N2F6
      Related
      ENSP00000413619.2, ENST00000441711.6
      Conserved Domains (3) summary
      cd00020
      Location:55 → 140
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:52 → 302
      Arm_2; Armadillo-like
      sd00043
      Location:56 → 84
      ARM; armadillo repeat [structural motif]

    2. NM_001161010.3 → NP_001154482.1  armadillo repeat-containing protein 10 isoform c

      See identical proteins and their annotated locations for NP_001154482.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) lacks an in-frame exon in the 3' coding region compared to variant A. This results in a shorter protein (isoform c) compared to isoform a.
      Source sequence(s)
      AI761577, AY150851, AY150852, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS55145.1
      UniProtKB/Swiss-Prot
      Q8N2F6
      Related
      ENSP00000396654.2, ENST00000428183.6
      Conserved Domains (3) summary
      cd00020
      Location:90 → 186
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:87 → 278
      Arm_2; Armadillo-like
      sd00043
      Location:91 → 119
      ARM; armadillo repeat [structural motif]

    3. NM_001161011.3 → NP_001154483.1  armadillo repeat-containing protein 10 isoform e

      See identical proteins and their annotated locations for NP_001154483.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (E) lacks two in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform e) compared to isoform a.
      Source sequence(s)
      AI761577, AK301565, AY150851, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS55147.1
      UniProtKB/Swiss-Prot
      Q8N2F6
      Related
      ENSP00000397969.1, ENST00000425331.5
      Conserved Domains (3) summary
      cd00020
      Location:55 → 140
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:52 → 278
      Arm_2; Armadillo-like
      sd00043
      Location:56 → 84
      ARM; armadillo repeat [structural motif]

    4. NM_001161012.3 → NP_001154484.1  armadillo repeat-containing protein 10 isoform d

      See identical proteins and their annotated locations for NP_001154484.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (D) lacks two in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform d) compared to isoform a.
      Source sequence(s)
      AI761577, AY150851, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS55148.1
      UniProtKB/Swiss-Prot
      Q8N2F6
      Related
      ENSP00000405612.1, ENST00000454559.5
      Conserved Domains (3) summary
      cd00020
      Location:55 → 151
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:52 → 243
      Arm_2; Armadillo-like
      sd00043
      Location:56 → 84
      ARM; armadillo repeat [structural motif]

    5. NM_001161013.3 → NP_001154485.1  armadillo repeat-containing protein 10 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (F) lacks three in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform f) compared to isoform a.
      Source sequence(s)
      AF275808, AI761577, AY150851, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS55149.1
      UniProtKB/TrEMBL
      C9J5N7
      Related
      ENSP00000440463.1, ENST00000541300.5
      Conserved Domains (3) summary
      cd00020
      Location:55 → 169
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:52 → 219
      Arm_2; Armadillo-like
      sd00043
      Location:56 → 84
      ARM; armadillo repeat [structural motif]

    6. NM_031905.5 → NP_114111.2  armadillo repeat-containing protein 10 isoform a

      See identical proteins and their annotated locations for NP_114111.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AI761577, AY150851, AY150854, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS5728.1
      UniProtKB/Swiss-Prot
      A8K703, B4DWJ8, F5GX65, Q75K91, Q75MG6, Q75ML8, Q8IZC1, Q8IZC2, Q8IZC3, Q8N2F6, Q9BTM6
      Related
      ENSP00000319412.3, ENST00000323716.8
      Conserved Domains (3) summary
      cd00020
      Location:90 → 175
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:87 → 337
      Arm_2; Armadillo-like
      sd00043
      Location:91 → 119
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      103075140..103099759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516601.4 → XP_011514903.1  armadillo repeat-containing protein 10 isoform X8

      Conserved Domains (3) summary
      cd00020
      Location:63 → 148
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:60 → 310
      Arm_2; Armadillo-like
      sd00043
      Location:64 → 92
      ARM; armadillo repeat [structural motif]

    2. XM_047420912.1 → XP_047276868.1  armadillo repeat-containing protein 10 isoform X1

    3. XM_047420914.1 → XP_047276870.1  armadillo repeat-containing protein 10 isoform X3

    4. XM_047420915.1 → XP_047276871.1  armadillo repeat-containing protein 10 isoform X6

    5. XM_047420913.1 → XP_047276869.1  armadillo repeat-containing protein 10 isoform X2

    6. XM_047420917.1 → XP_047276873.1  armadillo repeat-containing protein 10 isoform X9

    7. XM_017012684.3 → XP_016868173.1  armadillo repeat-containing protein 10 isoform X4

      Conserved Domains (3) summary
      cd00020
      Location:99 → 184
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:96 → 346
      Arm_2; Armadillo-like
      sd00043
      Location:100 → 128
      ARM; armadillo repeat [structural motif]

    8. XM_017012685.3 → XP_016868174.1  armadillo repeat-containing protein 10 isoform X5

    9. XM_047420916.1 → XP_047276872.1  armadillo repeat-containing protein 10 isoform X7

    10. XM_017012688.3 → XP_016868177.1  armadillo repeat-containing protein 10 isoform X10

    11. XM_005250628.4 → XP_005250685.1  armadillo repeat-containing protein 10 isoform X11

      UniProtKB/TrEMBL
      H7BXQ8
      Related
      ENSP00000319798.6, ENST00000323735.10
      Conserved Domains (2) summary
      cd00020
      Location:90 → 175
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:91 → 119
      ARM; armadillo repeat [structural motif]

    12. XM_047420918.1 → XP_047276874.1  armadillo repeat-containing protein 10 isoform X10

    13. XM_017012689.3 → XP_016868178.1  armadillo repeat-containing protein 10 isoform X12

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187559.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      144970..158099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      104390254..104414903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359163.1 → XP_054215138.1  armadillo repeat-containing protein 10 isoform X8

    2. XM_054359156.1 → XP_054215131.1  armadillo repeat-containing protein 10 isoform X1

    3. XM_054359158.1 → XP_054215133.1  armadillo repeat-containing protein 10 isoform X3

    4. XM_054359161.1 → XP_054215136.1  armadillo repeat-containing protein 10 isoform X6

    5. XM_054359157.1 → XP_054215132.1  armadillo repeat-containing protein 10 isoform X2

    6. XM_054359164.1 → XP_054215139.1  armadillo repeat-containing protein 10 isoform X9

    7. XM_054359159.1 → XP_054215134.1  armadillo repeat-containing protein 10 isoform X4

    8. XM_054359160.1 → XP_054215135.1  armadillo repeat-containing protein 10 isoform X5

    9. XM_054359162.1 → XP_054215137.1  armadillo repeat-containing protein 10 isoform X7

    10. XM_054359166.1 → XP_054215141.1  armadillo repeat-containing protein 10 isoform X10

    11. XM_054359167.1 → XP_054215142.1  armadillo repeat-containing protein 10 isoform X11

      UniProtKB/TrEMBL
      H7BXQ8

    12. XM_054359165.1 → XP_054215140.1  armadillo repeat-containing protein 10 isoform X10

    13. XM_054359168.1 → XP_054215143.1  armadillo repeat-containing protein 10 isoform X12

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N2F6.1 GenPept UniProtKB/Swiss-Prot:Q8N2F6

    Gene LinkOut

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