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    FBXO41 F-box protein 41 [ Homo sapiens (human) ]

    Gene ID: 150726, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FBXO41provided by HGNC
    Official Full Name
    F-box protein 41provided by HGNC
    Primary source
    HGNC:HGNC:29409
    See related
    Ensembl:ENSG00000163013 MIM:609108; AllianceGenome:HGNC:29409
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX41
    Summary
    This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014]
    Expression
    Biased expression in brain (RPKM 10.6), lymph node (RPKM 3.0) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FBXO41 in Genome Data Viewer
    Location:
    2p13.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (73254690..73284478, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (73267681..73297476, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73481818..73511606, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11637 Neighboring gene protease associated domain containing 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:73460911-73461442 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:73496386-73497329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11641 Neighboring gene uncharacterized LOC124907840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:73518267-73518962 Neighboring gene early growth response 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. F-box protein FBXO41 plays vital role in arsenic trioxide-mediated autophagic death of cancer cells. Agrawal Y, et al. Toxicol Appl Pharmacol, 2022 Apr 15. PMID 35278439
    2. Genetic analysis of the F-box only protein 41 gene in Chinese Han patients with Parkinson's disease. Liang H, et al. Parkinsonism Relat Disord, 2013 Oct. PMID 23777664
    3. F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2. Agrawal Y, et al. Int J Biochem Cell Biol, 2022 Jun. PMID 35598880
    4. Loss of the neuron-specific F-box protein FBXO41 models an ataxia-like phenotype in mice with neuronal migration defects and degeneration in the cerebellum. Mukherjee C, et al. J Neurosci, 2015 Jun 10. PMID 26063905, Free PMC Article
    5. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Watanabe N, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070733, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2.
      Title: F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2.
    2. F-box protein FBXO41 plays vital role in arsenic trioxide-mediated autophagic death of cancer cells.
      Title: F-box protein FBXO41 plays vital role in arsenic trioxide-mediated autophagic death of cancer cells.
    3. This study show that FBXO41 is a critical factor, not only for neuronal migration in the cerebellum, but also for its long-term integrity.
      Title: Loss of the neuron-specific F-box protein FBXO41 models an ataxia-like phenotype in mice with neuronal migration defects and degeneration in the cerebellum.
    4. Our finding suggests that the FBXO41gene may be a non-X chromosome-related Parkinson disease risk factor
      Title: Genetic analysis of the F-box only protein 41 gene in Chinese Han patients with Parkinson's disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37709

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033973.2 RefSeqGene

      Range
      5000..34788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080410.4 → NP_001073879.2  F-box only protein 41

      See identical proteins and their annotated locations for NP_001073879.2

      Status: REVIEWED

      Source sequence(s)
      AC010913
      Consensus CDS
      CCDS46337.2
      UniProtKB/Swiss-Prot
      G3V0Z7, Q2M1V8, Q8TF61
      Conserved Domains (4) summary
      PHA03307
      Location:347 → 557
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:199 → 346
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00034
      Location:659 → 685
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:557 → 592
      F-box-like

    2. NM_001371389.2 → NP_001358318.1  F-box only protein 41

      Status: REVIEWED

      Source sequence(s)
      AC010913
      Consensus CDS
      CCDS46337.2
      UniProtKB/Swiss-Prot
      G3V0Z7, Q2M1V8, Q8TF61
      Related
      ENSP00000430968.2, ENST00000520530.3
      Conserved Domains (4) summary
      PHA03307
      Location:347 → 557
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:199 → 346
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00034
      Location:659 → 685
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:557 → 592
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      73254690..73284478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443458.1 → XP_047299414.1  F-box only protein 41 isoform X1

      UniProtKB/Swiss-Prot
      G3V0Z7, Q2M1V8, Q8TF61

    2. XM_047443459.1 → XP_047299415.1  F-box only protein 41 isoform X1

      UniProtKB/Swiss-Prot
      G3V0Z7, Q2M1V8, Q8TF61

    3. XM_047443460.1 → XP_047299416.1  F-box only protein 41 isoform X1

      UniProtKB/Swiss-Prot
      G3V0Z7, Q2M1V8, Q8TF61

    4. XM_005264158.4 → XP_005264215.1  F-box only protein 41 isoform X3

      Conserved Domains (2) summary
      sd00034
      Location:265 → 291
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:163 → 201
      F-box-like; F-box-like

    5. XM_011532563.3 → XP_011530865.1  F-box only protein 41 isoform X2

      Conserved Domains (2) summary
      sd00034
      Location:411 → 437
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:309 → 347
      F-box-like; F-box-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      73267681..73297476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340685.1 → XP_054196660.1  F-box only protein 41 isoform X1

      UniProtKB/Swiss-Prot
      G3V0Z7, Q2M1V8, Q8TF61

    2. XM_054340686.1 → XP_054196661.1  F-box only protein 41 isoform X1

      UniProtKB/Swiss-Prot
      G3V0Z7, Q2M1V8, Q8TF61

    3. XM_054340687.1 → XP_054196662.1  F-box only protein 41 isoform X1

      UniProtKB/Swiss-Prot
      G3V0Z7, Q2M1V8, Q8TF61

    4. XM_054340688.1 → XP_054196663.1  F-box only protein 41 isoform X1

      UniProtKB/Swiss-Prot
      G3V0Z7, Q2M1V8, Q8TF61

    5. XM_054340690.1 → XP_054196665.1  F-box only protein 41 isoform X3

    6. XM_054340689.1 → XP_054196664.1  F-box only protein 41 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TF61.5 GenPept UniProtKB/Swiss-Prot:Q8TF61

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