ZDHHC20 zinc finger DHHC-type palmitoyltransferase 20 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZDHHC20provided by HGNC
Official Full Name: zinc finger DHHC-type palmitoyltransferase 20provided by HGNC
Primary source: HGNC:HGNC:20749
See related: Ensembl:ENSG00000180776 MIM:617972; AllianceGenome:HGNC:20749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DHHC20; DHHC-20; 4933421L13Rik
Summary: Enables protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Involved in peptidyl-L-cysteine S-palmitoylation and positive regulation by host of viral process. Located in Golgi membrane and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in stomach (RPKM 21.2), urinary bladder (RPKM 18.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q12.11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (21372571..21459303, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (20566901..20653645, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (21946710..22033442, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis.
Title: Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis.
ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression.
Title: ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression.
Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase.
Title: Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase.
Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis.
Title: Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis.
S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca(2+) signaling by Jurkat T cell receptors at the immune synapse.
Title: S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca(2+) signaling by Jurkat T cell receptors at the immune synapse.
DHHC20 Palmitoyl-Transferase Reshapes the Membrane to Foster Catalysis.
Title: DHHC20 Palmitoyl-Transferase Reshapes the Membrane to Foster Catalysis.
crystal structure determined; active site resides at the membrane-cytosol interface; acyl chain binds in a cavity formed by the transmembrane domain; propose a mechanism for acyl chain-length selectivity in DHHC enzymes on the basis of cavity mutants with preferences for shorter and longer acyl chains
Title: Fatty acyl recognition and transfer by an integral membrane S-acyltransferase.
Targeting of a peripheral modulator of EGFR signaling, DHHC20, causes a loss of signal regulation and susceptibility to EGFR inhibitor-induced cell death.
Title: Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling.
DHHC20 is a human N-terminal-myristoyl-directed palmitoyl acyltransferase involved in cellular transformation, that may play a role in cancer.
Title: DHHC20: a human palmitoyl acyltransferase that causes cellular transformation.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of zinc finger, DHHC-type containing 20 (ZDHHC20) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

RH69325 (e-PCR)
- UniSTS:72733

NoName (e-PCR)
- UniSTS:490024

PMC156606P1 (e-PCR)
- UniSTS:271408

RH11201 (e-PCR)
- UniSTS:58987

RH103875 (e-PCR)
- UniSTS:98200

GDB:631813 (e-PCR)
- UniSTS:158430

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-cysteine S-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-cysteine S-stearoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in peptidyl-L-cysteine S-palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation by host of viral process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation by host of viral process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle maturation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane	HDA more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: palmitoyltransferase ZDHHC20

Names: DHHC domain-containing cysteine-rich protein 20; acyltransferase ZDHHC20; probable palmitoyltransferase ZDHHC20; zinc finger DHHC domain-containing protein 20; zinc finger DHHC-type containing 20

NP_001273567.1

EC 2.3.1.225

NP_001316988.1

EC 2.3.1.225

NP_694983.2

EC 2.3.1.225

XP_006719859.1

EC 2.3.1.225

XP_006719860.1

EC 2.3.1.225

XP_011533332.1

EC 2.3.1.225

XP_016876014.1

EC 2.3.1.225

XP_047286198.1

EC 2.3.1.225

XP_047286199.1

EC 2.3.1.225

XP_047286200.1

EC 2.3.1.225

XP_047286201.1

EC 2.3.1.225

XP_047286202.1

EC 2.3.1.225

XP_047286203.1

EC 2.3.1.225

XP_047286204.1

EC 2.3.1.225

XP_054230365.1

EC 2.3.1.225

XP_054230366.1

EC 2.3.1.225

XP_054230367.1

EC 2.3.1.225

XP_054230368.1

EC 2.3.1.225

XP_054230369.1

EC 2.3.1.225

XP_054230370.1

EC 2.3.1.225

XP_054230371.1

EC 2.3.1.225

XP_054230372.1

EC 2.3.1.225

XP_054230373.1

EC 2.3.1.225

XP_054230374.1

EC 2.3.1.225

XP_054230375.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286638.2 → NP_001273567.1 palmitoyltransferase ZDHHC20 isoform 2

See identical proteins and their annotated locations for NP_001273567.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains multiple differences in the coding region, compared to variant 1, including initiation of translation at a downstream in-frame start codon. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AK299354, AL136219, BU685378

Consensus CDS

CCDS73551.1

UniProtKB/TrEMBL

B4DRN8

Related

ENSP00000443236.1, ENST00000542645.5

Conserved Domains (1) summary

cl19890
Location:52 → 238

zf-DHHC; DHHC palmitoyltransferase
NM_001330059.2 → NP_001316988.1 palmitoyltransferase ZDHHC20 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice site, contains an alternate exon in the 3' coding region and differs in its 3' UTR, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AB040396, AL136219, BC067898, BU685378, CR737535, DR003340

Consensus CDS

CCDS81758.1

UniProtKB/Swiss-Prot

A8MTV9, C9JG20, I6L9D4, Q2TB82, Q5W0Z9, Q6NVU8

UniProtKB/TrEMBL

B4DIW0

Related

ENSP00000383433.3, ENST00000400590.8

Conserved Domains (1) summary

cl19890
Location:16 → 301

zf-DHHC; DHHC palmitoyltransferase
NM_153251.4 → NP_694983.2 palmitoyltransferase ZDHHC20 isoform 1

See identical proteins and their annotated locations for NP_694983.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL136219, BC050367, BG720734, BU685378

Consensus CDS

CCDS45017.1

UniProtKB/TrEMBL

B4DIW0

Related

ENSP00000371905.3, ENST00000382466.7

Conserved Domains (1) summary

cl19890
Location:16 → 301

zf-DHHC; DHHC palmitoyltransferase

RNA

NR_104486.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL136219, BC067898, BU685378
NR_104487.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL136219, BC034944, BC110517, BU685378

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000013.11 Reference GRCh38.p14 Primary Assembly

Range

21372571..21459303 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006719796.2 → XP_006719859.1 palmitoyltransferase ZDHHC20 isoform X1

See identical proteins and their annotated locations for XP_006719859.1

UniProtKB/TrEMBL

B4DIW0

Conserved Domains (1) summary

cl19890
Location:16 → 301

DHHC; DHHC palmitoyltransferase
XM_006719797.2 → XP_006719860.1 palmitoyltransferase ZDHHC20 isoform X2

See identical proteins and their annotated locations for XP_006719860.1

UniProtKB/TrEMBL

B4DIW0

Conserved Domains (1) summary

cl19890
Location:16 → 301

DHHC; DHHC palmitoyltransferase
XM_047430246.1 → XP_047286202.1 palmitoyltransferase ZDHHC20 isoform X8
XM_047430245.1 → XP_047286201.1 palmitoyltransferase ZDHHC20 isoform X7
XM_047430244.1 → XP_047286200.1 palmitoyltransferase ZDHHC20 isoform X6

UniProtKB/TrEMBL

B4DRN8
XM_047430243.1 → XP_047286199.1 palmitoyltransferase ZDHHC20 isoform X4
XM_017020525.2 → XP_016876014.1 palmitoyltransferase ZDHHC20 isoform X5

Conserved Domains (1) summary

cl19890
Location:44 → 230

DHHC; DHHC palmitoyltransferase
XM_047430247.1 → XP_047286203.1 palmitoyltransferase ZDHHC20 isoform X10
XM_047430248.1 → XP_047286204.1 palmitoyltransferase ZDHHC20 isoform X10
XM_011535030.4 → XP_011533332.1 palmitoyltransferase ZDHHC20 isoform X9

Conserved Domains (1) summary

cl19890
Location:58 → 153

DHHC; DHHC palmitoyltransferase
XM_047430242.1 → XP_047286198.1 palmitoyltransferase ZDHHC20 isoform X3

Related

ENSP00000313583.9, ENST00000320220.13

RNA

XR_007063672.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060937.1 Alternate T2T-CHM13v2.0

Range

20566901..20653645 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054374390.1 → XP_054230365.1 palmitoyltransferase ZDHHC20 isoform X1
XM_054374391.1 → XP_054230366.1 palmitoyltransferase ZDHHC20 isoform X2
XM_054374397.1 → XP_054230372.1 palmitoyltransferase ZDHHC20 isoform X8
XM_054374396.1 → XP_054230371.1 palmitoyltransferase ZDHHC20 isoform X7
XM_054374395.1 → XP_054230370.1 palmitoyltransferase ZDHHC20 isoform X6

UniProtKB/TrEMBL

B4DRN8
XM_054374393.1 → XP_054230368.1 palmitoyltransferase ZDHHC20 isoform X4
XM_054374394.1 → XP_054230369.1 palmitoyltransferase ZDHHC20 isoform X5
XM_054374399.1 → XP_054230374.1 palmitoyltransferase ZDHHC20 isoform X10
XM_054374400.1 → XP_054230375.1 palmitoyltransferase ZDHHC20 isoform X10
XM_054374398.1 → XP_054230373.1 palmitoyltransferase ZDHHC20 isoform X9
XM_054374392.1 → XP_054230367.1 palmitoyltransferase ZDHHC20 isoform X3