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    LZIC leucine zipper and CTNNBIP1 domain containing [ Homo sapiens (human) ]

    Gene ID: 84328, updated on 3-Nov-2024

    Summary

    Official Symbol
    LZICprovided by HGNC
    Official Full Name
    leucine zipper and CTNNBIP1 domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:17497
    See related
    Ensembl:ENSG00000162441 MIM:610458; AllianceGenome:HGNC:17497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable beta-catenin binding activity. Predicted to be involved in negative regulation of Wnt signaling pathway. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 8.7), colon (RPKM 7.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LZIC in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9922118..9943391, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (9465032..9486296, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9982176..10003449, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9911316-9912116 Neighboring gene catenin beta interacting protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9919701-9920595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9931412-9932340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9932341-9933268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 236 Neighboring gene uncharacterized LOC124903838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9943986-9944775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9946851-9947439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9960261-9960762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9970922-9971595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9971596-9972268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9987872-9988381 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9990871-9991370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9998882-9999382 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9999383-9999883 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:10002582-10003781 Neighboring gene RN7SK pseudogene 269 Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene transmembrane protein 274, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    protein LZIC
    Names
    leucine zipper and CTNNBIP1 domain-containing protein
    leucine zipper and ICAT homologous domain-containing protein
    leucine zipper domain and ICAT homologous domain containing

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316973.2NP_001303902.1  protein LZIC isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK312550, AL357140, CB241987, DA538145
      Consensus CDS
      CCDS107.1
      UniProtKB/Swiss-Prot
      B2R6F0, B4E2N0, Q8WZA0, Q96IU1
      Related
      ENSP00000366418.1, ENST00000377213.1
      Conserved Domains (1) summary
      pfam06384
      Location:113188
      ICAT; Beta-catenin-interacting protein ICAT
    2. NM_001316974.2NP_001303903.1  protein LZIC isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice junctions in the 5' end compared to variant 1. The resulting isoform (b) is longer at the N-terminus compared to isoform a.
      Source sequence(s)
      AK304348, AL357140, CB241987, DA538145
      UniProtKB/Swiss-Prot
      Q8WZA0
      Conserved Domains (1) summary
      pfam06384
      Location:134209
      ICAT; Beta-catenin-interacting protein ICAT
    3. NM_001316975.2NP_001303904.1  protein LZIC isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate terminal exon compared to variant 1. The resulting isoform (c) has a longer and distinct C-terminus compared to isoform a.
      Source sequence(s)
      BI772110, BQ018333, DA538145
      UniProtKB/TrEMBL
      K7ES95
      Related
      ENSP00000468610.1, ENST00000488540.5
      Conserved Domains (1) summary
      pfam06384
      Location:113172
      ICAT; Beta-catenin-interacting protein ICAT
    4. NM_001316976.2NP_001303905.1  protein LZIC isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks two alternate coding exons compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL357140, CB241987, DA538145, DB106543
      Conserved Domains (1) summary
      pfam04111
      Location:887
      APG6; Autophagy protein Apg6
    5. NM_032368.5NP_115744.2  protein LZIC isoform a

      See identical proteins and their annotated locations for NP_115744.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AA220235, AL357140, BC007240, CB241987
      Consensus CDS
      CCDS107.1
      UniProtKB/Swiss-Prot
      B2R6F0, B4E2N0, Q8WZA0, Q96IU1
      Related
      ENSP00000366430.1, ENST00000377223.6
      Conserved Domains (1) summary
      pfam06384
      Location:113188
      ICAT; Beta-catenin-interacting protein ICAT

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      9922118..9943391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263506.3XP_005263563.1  protein LZIC isoform X1

      See identical proteins and their annotated locations for XP_005263563.1

      UniProtKB/TrEMBL
      K7ES95
      Conserved Domains (1) summary
      pfam06384
      Location:113172
      ICAT; Beta-catenin-interacting protein ICAT
    2. XM_017002546.2XP_016858035.1  protein LZIC isoform X2

      Conserved Domains (2) summary
      pfam06384
      Location:113171
      ICAT; Beta-catenin-interacting protein ICAT
      pfam04111
      Location:887
      APG6; Autophagy protein Apg6
    3. XM_017002547.2XP_016858036.1  protein LZIC isoform X2

      Conserved Domains (2) summary
      pfam06384
      Location:113171
      ICAT; Beta-catenin-interacting protein ICAT
      pfam04111
      Location:887
      APG6; Autophagy protein Apg6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      9465032..9486296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339191.1XP_054195166.1  protein LZIC isoform X1

    2. XM_054339193.1XP_054195168.1  protein LZIC isoform X2

    3. XM_054339192.1XP_054195167.1  protein LZIC isoform X2