TRIM33 tripartite motif containing 33 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM33provided by HGNC
Official Full Name: tripartite motif containing 33provided by HGNC
Primary source: HGNC:HGNC:16290
See related: Ensembl:ENSG00000197323 MIM:605769; AllianceGenome:HGNC:16290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA
Summary: The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 10.8), endometrium (RPKM 8.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p13.2

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (114392790..114511203, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (114404478..114522654, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (114935412..115053824, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM33 promotes glycolysis through regulating P53 K48-linked ubiquitination to promote esophageal squamous cell carcinoma growth.
Title: TRIM33 promotes glycolysis through regulating P53 K48-linked ubiquitination to promote esophageal squamous cell carcinoma growth.
TRIM33 enhances the ubiquitination of TFRC to enhance the susceptibility of liver cancer cells to ferroptosis.
Title: TRIM33 enhances the ubiquitination of TFRC to enhance the susceptibility of liver cancer cells to ferroptosis.
TRIM33 loss in multiple myeloma is associated with genomic instability and sensitivity to PARP inhibitors.
Title: TRIM33 loss in multiple myeloma is associated with genomic instability and sensitivity to PARP inhibitors.
TIF1gamma and SMAD4 regulation in colorectal cancer: impact on cell proliferation and liver metastasis.
Title: TIF1γ and SMAD4 regulation in colorectal cancer: impact on cell proliferation and liver metastasis.
Tripartite motif containing 33 demonstrated anticancer effect by degrading c-Myc: Limitation of glutamine metabolism and proliferation in endometrial carcinoma cells.
Title: Tripartite motif containing 33 demonstrated anticancer effect by degrading c‑Myc: Limitation of glutamine metabolism and proliferation in endometrial carcinoma cells.
Tubular cell transcriptional intermediary factor 1gamma deficiency exacerbates kidney injury-induced tubular cell polyploidy and fibrosis.
Title: Tubular cell transcriptional intermediary factor 1γ deficiency exacerbates kidney injury-induced tubular cell polyploidy and fibrosis.
E3 ubiquitin ligase Trim33 ubiquitylates Annexin A2 to promote NF-kappaB induced skin inflammation in psoriasis.
Title: E3 ubiquitin ligase Trim33 ubiquitylates Annexin A2 to promote NF-κB induced skin inflammation in psoriasis.
Downregulation of TRIM33 Promotes Survival and Epithelial-Mesenchymal Transition in Gastric Cancer.
Title: Downregulation of TRIM33 Promotes Survival and Epithelial-Mesenchymal Transition in Gastric Cancer.
TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.
Title: TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.
KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.
Title: KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (62)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants on 1p13.2 associate with risk of autism. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-75362 (e-PCR)
- UniSTS:61445

D1S2219 (e-PCR)
- UniSTS:151853

RH65165 (e-PCR)
- UniSTS:90676

WI-12516 (e-PCR)
- UniSTS:21046

SHGC-75367 (e-PCR)
- UniSTS:55891

SHGC-75347 (e-PCR)
- UniSTS:39564

SHGC-82151 (e-PCR)
- UniSTS:103066

SHGC-75356 (e-PCR)
- UniSTS:70587

G61971 (e-PCR)
- UniSTS:137413

AL009900 (e-PCR)
- UniSTS:34247

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables R-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables co-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM33

Names: RET-fused gene 7 protein; RING-type E3 ubiquitin transferase TRIM33; TIF1-gamma; ectodermin homolog; protein Rfg7; transcriptional intermediary factor 1 gamma

NP_056990.3

EC 2.3.2.27

NP_148980.2

EC 2.3.2.27

XP_005270993.1

EC 2.3.2.27

XP_005270994.1

EC 2.3.2.27

XP_011539870.1

EC 2.3.2.27

XP_016856943.1

EC 2.3.2.27

XP_047278468.1

EC 2.3.2.27

XP_054192952.1

EC 2.3.2.27

XP_054192953.1

EC 2.3.2.27

XP_054192954.1

EC 2.3.2.27

XP_054192955.1

EC 2.3.2.27

XP_054192956.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023287.2 RefSeqGene

Range

5000..123413

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_015906.4 → NP_056990.3 E3 ubiquitin-protein ligase TRIM33 isoform alpha

See identical proteins and their annotated locations for NP_056990.3

Status: REVIEWED

Description

Transcript Variant: This variant (a) encodes the longer isoform (alpha).

Source sequence(s)

AB029036, AF119043, AK023434, AL035410, AL390241, CN267696

Consensus CDS

CCDS872.1

UniProtKB/Swiss-Prot

O95855, Q5TG72, Q5TG73, Q5TG74, Q9C017, Q9UJ79, Q9UPN9

Related

ENSP00000351250.2, ENST00000358465.7

Conserved Domains (6) summary

cd05502
Location:958 → 1083

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:319 → 445

BBC; B-Box C-terminal domain

smart00336
Location:212 → 248

BBOX; B-Box-type zinc finger

cd00021
Location:274 → 312

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:124 → 188

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd15624
Location:889 → 934

PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
NM_033020.3 → NP_148980.2 E3 ubiquitin-protein ligase TRIM33 isoform beta

See identical proteins and their annotated locations for NP_148980.2

Status: REVIEWED

Description

Transcript Variant: This variant (b) lacks exon 15 of the coding region. The reading frame is maintained and the encoded protein, isoform beta, lacks an internal 17 aa fragment as compared to isoform alpha.

Source sequence(s)

AB029036, AF119043, AF220137, AK023434, AL035410, AL390241, CN267696

Consensus CDS

CCDS873.1

Related

ENSP00000358556.2, ENST00000369543.6

Conserved Domains (6) summary

cd05502
Location:958 → 1066

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:319 → 445

BBC; B-Box C-terminal domain

smart00336
Location:212 → 248

BBOX; B-Box-type zinc finger

cd00021
Location:274 → 312

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:124 → 188

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd15624
Location:889 → 934

PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

114392790..114511203 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047422512.1 → XP_047278468.1 E3 ubiquitin-protein ligase TRIM33 isoform X4
XM_011541568.4 → XP_011539870.1 E3 ubiquitin-protein ligase TRIM33 isoform X2

Conserved Domains (6) summary

cd05502
Location:981 → 1106

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:319 → 445

BBC; B-Box C-terminal domain

smart00336
Location:212 → 248

BBOX; B-Box-type zinc finger

cd00021
Location:274 → 312

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:124 → 188

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd15624
Location:912 → 957

PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
XM_005270937.5 → XP_005270994.1 E3 ubiquitin-protein ligase TRIM33 isoform X3

Conserved Domains (6) summary

cd05502
Location:982 → 1090

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:319 → 445

BBC; B-Box C-terminal domain

smart00336
Location:212 → 248

BBOX; B-Box-type zinc finger

cd00021
Location:274 → 312

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:124 → 188

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd15624
Location:913 → 958

PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
XM_005270936.5 → XP_005270993.1 E3 ubiquitin-protein ligase TRIM33 isoform X1

Conserved Domains (6) summary

cd05502
Location:982 → 1107

Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...

smart00502
Location:319 → 445

BBC; B-Box C-terminal domain

smart00336
Location:212 → 248

BBOX; B-Box-type zinc finger

cd00021
Location:274 → 312

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:124 → 188

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd15624
Location:913 → 958

PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
XM_017001454.3 → XP_016856943.1 E3 ubiquitin-protein ligase TRIM33 isoform X5