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    TARM1 T cell-interacting, activating receptor on myeloid cells 1 [ Homo sapiens (human) ]

    Gene ID: 441864, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TARM1provided by HGNC
    Official Full Name
    T cell-interacting, activating receptor on myeloid cells 1provided by HGNC
    Primary source
    HGNC:HGNC:37250
    See related
    Ensembl:ENSG00000248385 MIM:616802; AllianceGenome:HGNC:37250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OLT-2
    Summary
    Enables immunoglobulin receptor binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward bone marrow (RPKM 2.5) See more
    Orthologs
    mouse all
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    Genomic context

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    See TARM1 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54069895..54081365, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57148389..57159893, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54573149..54584634, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 6 Neighboring gene Sharpr-MPRA regulatory region 12456 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:54526043-54526246 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:54539139-54539714 Neighboring gene V-set and transmembrane domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54605952-54606928 Neighboring gene osteoclast associated Ig-like receptor Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene TCF3 fusion partner

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Breakpoint characterization of a novel approximately 59 kb genomic deletion on 19q13.42 in autosomal-dominant retinitis pigmentosa with incomplete penetrance. Köhn L, et al. Eur J Hum Genet, 2009 May. PMID 19050727, Free PMC Article
    2. TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils. Radjabova V, et al. J Immunol, 2015 Oct 1. PMID 26311901, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables immunoglobulin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of CD4-positive, alpha-beta T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    T-cell-interacting, activating receptor on myeloid cells protein 1
    Names
    OSCAR-like transcript-2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135686.3 → NP_001129158.2  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC012314, AC245052, DQ479398
      Consensus CDS
      CCDS46173.1
      UniProtKB/Swiss-Prot
      B4DWY4, B6A8C7
      Related
      ENSP00000439454.1, ENST00000432826.2
      Conserved Domains (2) summary
      smart00410
      Location:35 → 98
      IG_like; Immunoglobulin like
      cl11960
      Location:124 → 219
      Ig; Immunoglobulin domain

    2. NM_001330650.1 → NP_001317579.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC245052, AK301730
      Consensus CDS
      CCDS82395.1
      UniProtKB/TrEMBL
      A0A087X1Q6
      Related
      ENSP00000484383.1, ENST00000616041.4
      Conserved Domains (2) summary
      smart00410
      Location:43 → 106
      IG_like; Immunoglobulin like
      cl11960
      Location:132 → 227
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54069895..54081365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      44262..55747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329682.1 → XP_054185657.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform X1

    RNA

    1. XR_008485659.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      44262..55747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330177.1 → XP_054186152.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform X2

    RNA

    1. XR_008485691.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NW_003571056.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      44262..55747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330474.1 → XP_054186449.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform X3

    RNA

    1. XR_008485696.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NW_003571057.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      44262..55747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330727.1 → XP_054186702.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform X4

    RNA

    1. XR_008485702.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NW_003571058.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      44262..55747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330957.1 → XP_054186932.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform X5

    RNA

    1. XR_008485708.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NW_003571059.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      44262..55747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331238.1 → XP_054187213.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform X6

    RNA

    1. XR_008485713.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      44262..55747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331513.1 → XP_054187488.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform X7

    RNA

    1. XR_008485720.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_8

    Genomic

    1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

      Range
      44262..55747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333553.1 → XP_054189528.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform X8

    RNA

    1. XR_008485851.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      44262..55747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333654.1 → XP_054189629.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform X9

    RNA

    1. XR_008485856.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57148389..57159893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321052.1 → XP_054177027.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform X10

    RNA

    1. XR_008485154.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B6A8C7.2 GenPept UniProtKB/Swiss-Prot:B6A8C7

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