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    ARL17A ARF like GTPase 17A [ Homo sapiens (human) ]

    Gene ID: 51326, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ARL17Aprovided by HGNC
    Official Full Name
    ARF like GTPase 17Aprovided by HGNC
    Primary source
    HGNC:HGNC:24096
    See related
    Ensembl:ENSG00000185829 AllianceGenome:HGNC:24096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARF1P2; ARL17P1
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 3.4), appendix (RPKM 3.4) and 25 other tissues See more
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    Genomic context

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    See ARL17A in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (46500290..46579722, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47361441..47441293, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44586045..44657088, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37A Neighboring gene ARF like GTPase 17B Neighboring gene RNA, 7SL, cytoplasmic 656, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7330 Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene N-ethylmaleimide-sensitive factor pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44569061-44569562 Neighboring gene RDM1 pseudogene 2 Neighboring gene RNA, 7SL, cytoplasmic 199, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:44704776-44705308 Neighboring gene N-ethylmaleimide sensitive factor, vesicle fusing ATPase Neighboring gene vesicle-associated membrane protein 5-like Neighboring gene ribosomal protein S7 pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    2. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    4. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like 17-like
    Names
    ADP ribosylation factor like GTPase 17A
    ADP-ribosylation factor 7

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113738.2 → NP_001107210.1  ADP-ribosylation factor-like 17-like isoform a

      See identical proteins and their annotated locations for NP_001107210.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (a).
      Source sequence(s)
      AB209344, AC138645
      Consensus CDS
      CCDS45718.1
      UniProtKB/Swiss-Prot
      B0AZR6, Q59FW5, Q8IVW1, Q8N6E2, Q8TD73, Q8WW54, Q9NZD5, Q9P158
      UniProtKB/TrEMBL
      A0A0G2JMH3, A8K0M5
      Related
      ENSP00000337478.6, ENST00000336125.6
      Conserved Domains (3) summary
      COG1100
      Location:13 → 88
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam15840
      Location:115 → 176
      ARL17; ADP-ribosylation factor-like protein 17
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001288811.1 → NP_001275740.1  ADP-ribosylation factor-like 17-like isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate 3' exon structure, compared to variant 1. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC138645, BX102203, DA761795, DA979569, DB065209, HY151357
      Consensus CDS
      CCDS74087.1
      UniProtKB/TrEMBL
      A0A087WVX3, A0A994J7P5
      Related
      ENSP00000331563.5, ENST00000329240.10
      Conserved Domains (3) summary
      COG1100
      Location:13 → 87
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam13900
      Location:93 → 118
      GVQW; Putative domain of unknown function
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001288812.1 → NP_001275741.1  ADP-ribosylation factor-like 17-like isoform b

      See identical proteins and their annotated locations for NP_001275741.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes an alternate 3' exon structure, compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a. Both variants 2 and 4 encode the same isoform (b).
      Source sequence(s)
      CA449330, DB027627, DB065209
      Consensus CDS
      CCDS45717.1
      UniProtKB/Swiss-Prot
      Q8IVW1
      Related
      ENSP00000516301.1, ENST00000706254.1
      Conserved Domains (1) summary
      cl21455
      Location:1 → 88
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001288813.1 → NP_001275742.1  ADP-ribosylation factor-like 17-like isoform d

      See identical proteins and their annotated locations for NP_001275742.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform d, which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC138645, BX102203, DB065209, DB241677
      Consensus CDS
      CCDS74086.1
      UniProtKB/TrEMBL
      A0A087WY76, I3L2E4
      Related
      ENSP00000481578.1, ENST00000622488.6
      Conserved Domains (1) summary
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_001330244.1 → NP_001317173.1  ADP-ribosylation factor-like 17-like isoform e

      Status: VALIDATED

      Source sequence(s)
      AA911712, AC138645
      Consensus CDS
      CCDS82146.1
      UniProtKB/TrEMBL
      I3L1V5, I3L2E4
      Related
      ENSP00000459759.1, ENST00000573185.5
      Conserved Domains (2) summary
      COG1100
      Location:13 → 85
      Gem1; GTPase SAR1 family domain [General function prediction only]
      cl21455
      Location:1 → 86
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. NM_001411134.1 → NP_001398063.1  ADP-ribosylation factor-like 17-like isoform f

      Status: VALIDATED

      Source sequence(s)
      AC138645
      Consensus CDS
      CCDS92351.1
      UniProtKB/TrEMBL
      I3L3L1
      Related
      ENSP00000516307.1, ENST00000706260.1

    7. NM_016632.2 → NP_057716.2  ADP-ribosylation factor-like 17-like isoform b

      See identical proteins and their annotated locations for NP_057716.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 3' exon structure, compared to variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a. Both variants 2 and 4 encode the same isoform (b).
      Source sequence(s)
      AB209344, AC138645, AF208864
      Consensus CDS
      CCDS45717.1
      UniProtKB/Swiss-Prot
      Q8IVW1
      Related
      ENSP00000416535.2, ENST00000445552.6
      Conserved Domains (1) summary
      cl21455
      Location:1 → 88
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      46500290..46579722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257439.6 → XP_005257496.1  ADP-ribosylation factor-like 17-like isoform X4

      See identical proteins and their annotated locations for XP_005257496.1

      UniProtKB/Swiss-Prot
      Q8IVW1
      Related
      ENSP00000516294.1, ENST00000706247.1
      Conserved Domains (1) summary
      cl21455
      Location:1 → 88
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_011524876.4 → XP_011523178.1  ADP-ribosylation factor-like 17-like isoform X2

      See identical proteins and their annotated locations for XP_011523178.1

      UniProtKB/TrEMBL
      A0A0G2JMH3, A0A994J5U5
      Related
      ENSP00000516303.1, ENST00000706256.1
      Conserved Domains (3) summary
      COG1100
      Location:13 → 88
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam15840
      Location:115 → 176
      ARL17; ADP-ribosylation factor-like protein 17
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_017024729.3 → XP_016880218.1  ADP-ribosylation factor-like 17-like isoform X2

      UniProtKB/TrEMBL
      A0A0G2JMH3, A0A994J5U5
      Related
      ENSP00000516305.1, ENST00000706258.1
      Conserved Domains (3) summary
      COG1100
      Location:13 → 88
      Gem1; GTPase SAR1 family domain [General function prediction only]
      pfam15840
      Location:115 → 176
      ARL17; ADP-ribosylation factor-like protein 17
      cl21455
      Location:1 → 87
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_047436213.1 → XP_047292169.1  ADP-ribosylation factor-like 17-like isoform X1

      Related
      ENSP00000516298.1, ENST00000706251.1

    5. XM_047436214.1 → XP_047292170.1  ADP-ribosylation factor-like 17-like isoform X3

      UniProtKB/TrEMBL
      I3L1A0
      Related
      ENSP00000516304.1, ENST00000706257.1

    RNA

    1. XR_934479.3 RNA Sequence

    2. XR_934475.4 RNA Sequence

    3. XR_934478.4 RNA Sequence

    4. XR_934477.4 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187663.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      976573..1099388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330125.1 → XP_054186100.1  ADP-ribosylation factor-like 17-like isoform X4

    2. XM_054330126.1 → XP_054186101.1  ADP-ribosylation factor-like 17-like isoform X4

    3. XM_054330124.1 → XP_054186099.1  ADP-ribosylation factor-like 17-like isoform X4

    4. XM_054330121.1 → XP_054186096.1  ADP-ribosylation factor-like 17-like isoform X2

      UniProtKB/TrEMBL
      A0A994J5U5

    5. XM_054330120.1 → XP_054186095.1  ADP-ribosylation factor-like 17-like isoform X2

      UniProtKB/TrEMBL
      A0A994J5U5

    6. XM_054330119.1 → XP_054186094.1  ADP-ribosylation factor-like 17-like isoform X1

    7. XM_054330122.1 → XP_054186097.1  ADP-ribosylation factor-like 17-like isoform X3

      UniProtKB/TrEMBL
      I3L1A0

    8. XM_054330123.1 → XP_054186098.1  ADP-ribosylation factor-like 17-like isoform X5

    RNA

    1. XR_008485686.1 RNA Sequence

    2. XR_008485689.1 RNA Sequence

    3. XR_008485688.1 RNA Sequence

    4. XR_008485687.1 RNA Sequence

    5. XR_008485683.1 RNA Sequence

    6. XR_008485685.1 RNA Sequence

    7. XR_008485684.1 RNA Sequence

    8. XR_008485682.1 RNA Sequence

    9. XR_008485681.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      47361441..47441293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316377.1 → XP_054172352.1  ADP-ribosylation factor-like 17-like isoform X4

    2. XM_054316376.1 → XP_054172351.1  ADP-ribosylation factor-like 17-like isoform X4

    3. XM_054316373.1 → XP_054172348.1  ADP-ribosylation factor-like 17-like isoform X2

      UniProtKB/TrEMBL
      A0A994J5U5

    4. XM_054316372.1 → XP_054172347.1  ADP-ribosylation factor-like 17-like isoform X1

    5. XM_054316374.1 → XP_054172349.1  ADP-ribosylation factor-like 17-like isoform X3

      UniProtKB/TrEMBL
      I3L1A0

    6. XM_054316375.1 → XP_054172350.1  ADP-ribosylation factor-like 17-like isoform X6

    RNA

    1. XR_008484830.1 RNA Sequence

    2. XR_008484828.1 RNA Sequence

    3. XR_008484827.1 RNA Sequence

    4. XR_008484831.1 RNA Sequence

    5. XR_008484829.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_003653.1: Suppressed sequence

      Description
      NR_003653.1: This RefSeq was permanently suppressed because it is now thought that this gene expresses a protein.
    Nucleotide Protein
    Heading Accession and Version

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