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    CAPN3 calpain 3 [ Desmodus rotundus (common vampire bat) ]

    Gene ID: 112311921, updated on 30-Mar-2024

    Summary

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    Gene symbol
    CAPN3
    Gene description
    calpain 3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Desmodus rotundus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Phyllostomidae; Desmodontinae; Desmodus
    Orthologs
    human mouse all
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    Genomic context

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    See CAPN3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_02 current HLdesRot8A (GCF_022682495.1) 7 NC_071393.1 (75943279..75989433)
    101 previous assembly ASM294091v2 (GCF_002940915.1) Unplaced Scaffold NW_020093309.1 (62579404..62625232, complement)

    Chromosome 7 - NC_071393.1Genomic Context describing neighboring genes Neighboring gene glucosidase alpha, neutral C Neighboring gene 40S ribosomal protein S17-like Neighboring gene 60S ribosomal protein L12-like Neighboring gene zinc finger protein 106 Neighboring gene synaptosome associated protein 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calpain-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_022682495.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference HLdesRot8A Primary Assembly

    Genomic

    1. NC_071393.1 Reference HLdesRot8A Primary Assembly

      Range
      75943279..75989433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024568405.3 → XP_024424173.1  calpain-3 isoform X2

      Conserved Domains (4) summary
      pfam00648
      Location:75 → 415
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:436 → 579
      Calpain_III; Calpain large subunit, domain III
      pfam16648
      Location:583 → 652
      Calpain_u2; Unstructured region on Calpain-3
      cd16190
      Location:653 → 821
      EFh_PEF_CAPN3; Calcium-activated neutral

    2. XM_024568406.3 → XP_024424174.1  calpain-3 isoform X3

      Conserved Domains (4) summary
      pfam00648
      Location:75 → 415
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:436 → 579
      Calpain_III; Calpain large subunit, domain III
      pfam16648
      Location:583 → 646
      Calpain_u2; Unstructured region on Calpain-3
      cd16190
      Location:647 → 815
      EFh_PEF_CAPN3; Calcium-activated neutral

    3. XM_045202116.2 → XP_045058051.1  calpain-3 isoform X1

    Nucleotide Protein
    Heading Accession and Version

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