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    Fam210a family with sequence similarity 210, member A [ Mus musculus (house mouse) ]

    Gene ID: 108654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam210aprovided by MGI
    Official Full Name
    family with sequence similarity 210, member Aprovided by MGI
    Primary source
    MGI:MGI:1914000
    See related
    Ensembl:ENSMUSG00000038121 AllianceGenome:MGI:1914000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933403F05Rik
    Summary
    Located in mitochondrion. Orthologous to human FAM210A (family with sequence similarity 210 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 8.5), kidney adult (RPKM 5.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam210a in Genome Data Viewer
    Location:
    18 E2; 18 40.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (68393248..68433404, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (68260175..68300333, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene predicted gene, 52336 Neighboring gene VISTA enhancer mm304 Neighboring gene STARR-seq mESC enhancer starr_44925 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9174 Neighboring gene STARR-seq mESC enhancer starr_44926 Neighboring gene microRNA 7219 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:68459940-68460049 Neighboring gene STARR-seq mESC enhancer starr_44927 Neighboring gene RNA (guanine-7-) methyltransferase Neighboring gene melanocortin 5 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes. Qiu J, et al. Nat Commun, 2023 Oct 10. PMID 37816711, Free PMC Article
    2. Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts. Tanaka KI, et al. Calcif Tissue Int, 2020 May. PMID 31980842
    3. FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis. Wu J, et al. Cardiovasc Res, 2023 Nov 15. PMID 37522353, Free PMC Article
    4. MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling. Wu J, et al. EMBO Mol Med, 2021 Feb 5. PMID 33369227, Free PMC Article
    5. FAM210A is a novel determinant of bone and muscle structure and strength. Tanaka KI, et al. Proc Natl Acad Sci U S A, 2018 Apr 17. PMID 29618611, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis.
      Title: FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis.
    2. FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
      Title: FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
    3. MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling.
      Title: MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling.
    4. Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts.
      Title: Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts.
    5. Fam210a was expressed in muscle mitochondria and cytoplasm but not in bone. Nevertheless, in genetically modified mouse models, Fam210a strongly influenced the structure and strength of both muscle and bone.
      Title: FAM210A is a novel determinant of bone and muscle structure and strength.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC48232

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein FAM210A
    Names
    uncharacterized protein C18orf19 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153794.4 → NP_722489.1  protein FAM210A

      See identical proteins and their annotated locations for NP_722489.1

      Status: VALIDATED

      Source sequence(s)
      AC111069, AK077093, AK147662, BQ176997
      Consensus CDS
      CCDS29326.1
      UniProtKB/Swiss-Prot
      Q3TXD0, Q8BGY7, Q8BNY5
      Related
      ENSMUSP00000045927.7, ENSMUST00000042852.7
      Conserved Domains (2) summary
      pfam05178
      Location:230 → 270
      Kri1; KRI1-like family
      pfam06916
      Location:125 → 212
      DUF1279; Protein of unknown function (DUF1279)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      68393248..68433404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525524.5 → XP_006525587.1  protein FAM210A isoform X1

      See identical proteins and their annotated locations for XP_006525587.1

      UniProtKB/Swiss-Prot
      Q3TXD0, Q8BGY7, Q8BNY5
      Conserved Domains (2) summary
      pfam05178
      Location:230 → 270
      Kri1; KRI1-like family
      pfam06916
      Location:125 → 212
      DUF1279; Protein of unknown function (DUF1279)

    2. XM_030250272.2 → XP_030106132.1  protein FAM210A isoform X1

      UniProtKB/Swiss-Prot
      Q3TXD0, Q8BGY7, Q8BNY5
      Conserved Domains (2) summary
      pfam05178
      Location:230 → 270
      Kri1; KRI1-like family
      pfam06916
      Location:125 → 212
      DUF1279; Protein of unknown function (DUF1279)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGY7.1 GenPept UniProtKB/Swiss-Prot:Q8BGY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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