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    Slc38a4 solute carrier family 38, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 69354, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc38a4provided by MGI
    Official Full Name
    solute carrier family 38, member 4provided by MGI
    Primary source
    MGI:MGI:1916604
    See related
    Ensembl:ENSMUSG00000022464 AllianceGenome:MGI:1916604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ata3; SNAT4; mATA3; mNAT3; 1110012E16Rik; 1700012A18Rik
    Summary
    Enables L-arginine transmembrane transporter activity and neutral L-amino acid:sodium symporter activity. Involved in L-alanine import across plasma membrane and L-arginine transmembrane transport. Predicted to be located in microvillus membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; gut; and liver. Orthologous to human SLC38A4 (solute carrier family 38 member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 139.1), placenta adult (RPKM 78.5) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc38a4 in Genome Data Viewer
    Location:
    15 F1; 15 52.77 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (96892701..96953837, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (96994816..97055956, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39603 Neighboring gene predicted gene, 32677 Neighboring gene ribosomal protein L10A, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E5511 Neighboring gene STARR-seq mESC enhancer starr_39604 Neighboring gene STARR-seq mESC enhancer starr_39606 Neighboring gene STARR-seq mESC enhancer starr_39607 Neighboring gene STARR-seq mESC enhancer starr_39610 Neighboring gene predicted gene, 32840 Neighboring gene STARR-seq mESC enhancer starr_39612 Neighboring gene predicted gene, 32789 Neighboring gene predicted gene, 32733

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation. Xie Z, et al. Cell Rep, 2022 Feb 22. PMID 35196486, Free PMC Article
    2. Mouse system-N amino acid transporter, mNAT3, expressed in hepatocytes and regulated by insulin-activated and phosphoinositide 3-kinase-dependent signalling. Gu S, et al. Biochem J, 2003 May 1. PMID 12537539, Free PMC Article
    3. Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter. Padmanabhan Iyer R, et al. PLoS One, 2013. PMID 23451088, Free PMC Article
    4. Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein. Shi Q, et al. J Biol Chem, 2011 Nov 4. PMID 21917917, Free PMC Article
    5. ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer. Kim HS, et al. Exp Mol Med, 2023 Jan. PMID 36599932, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer.
      Title: ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer.
    2. Slc38a4/SNAT4 mutant mice could be a promising model for the analysis of placental defects.
      Title: Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice.
    3. results suggest that cysteine residues 249 and 321 form a disulfide bridge, which plays an important role in substrate transport but has no effect on trafficking of SNAT4 to the cell surface.
      Title: Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter.
    4. Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein
      Title: Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein.
    5. Ata3 has been identified as an imprinted gene by high-throughput screening using RIKEN cDNA microarray.
      Title: Asb4, Ata3, and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray.
    6. crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4, Slc38a2, and Slc2a3) may be a component of the genetic control of nutrient supply and demand during mammalian development
      Title: Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Gene trapped (2) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-arginine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alanine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alanine:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neutral L-amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alanine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-alanine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-alanine import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-alanine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-arginine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium-coupled neutral amino acid transporter 4
    Names
    Na(+)-coupled neutral amino acid transporter 4
    amino acid transporter A3
    system A amino acid transporter 3
    system-N amino acid transporter 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358058.1 → NP_001344987.1  sodium-coupled neutral amino acid transporter 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC113177, AC158560
      Consensus CDS
      CCDS27779.1
      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Related
      ENSMUSP00000154818.2, ENSMUST00000230086.2
      Conserved Domains (1) summary
      cl00456
      Location:75 → 535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001358059.1 → NP_001344988.1  sodium-coupled neutral amino acid transporter 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC113177, AC158560
      Consensus CDS
      CCDS27779.1
      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Related
      ENSMUSP00000127676.2, ENSMUST00000166223.2
      Conserved Domains (1) summary
      cl00456
      Location:75 → 535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_001358060.1 → NP_001344989.1  sodium-coupled neutral amino acid transporter 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC113177, AC158560
      Consensus CDS
      CCDS27779.1
      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Related
      ENSMUSP00000155158.2, ENSMUST00000231039.2
      Conserved Domains (1) summary
      cl00456
      Location:75 → 535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. NM_027052.3 → NP_081328.2  sodium-coupled neutral amino acid transporter 4

      See identical proteins and their annotated locations for NP_081328.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK051023
      Consensus CDS
      CCDS27779.1
      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Related
      ENSMUSP00000023101.4, ENSMUST00000023101.10
      Conserved Domains (1) summary
      cl00456
      Location:75 → 535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      96892701..96953837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521350.5 → XP_006521413.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      See identical proteins and their annotated locations for XP_006521413.1

      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Conserved Domains (1) summary
      cl00456
      Location:75 → 535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_006521351.4 → XP_006521414.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      See identical proteins and their annotated locations for XP_006521414.1

      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Conserved Domains (1) summary
      cl00456
      Location:75 → 535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1S9.1 GenPept UniProtKB/Swiss-Prot:Q8R1S9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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