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    LOC127815977 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129183721-129184405 [ Homo sapiens (human) ]

    Gene ID: 127815977, updated on 12-Sep-2024

    Summary

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    Gene symbol
    LOC127815977
    Gene description
    NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129183721-129184405
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]
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    Genomic context

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    See LOC127815977 in Genome Data Viewer
    Location:
    chromosome: 9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (126421442..126422126)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (138627211..138627895)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (129183721..129184405)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20286 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129089674-129090325 Neighboring gene Sharpr-MPRA regulatory region 7128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129097847-129098348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129098349-129098848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129109020-129109980 Neighboring gene multivesicular body subunit 12B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129138261-129138866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129138867-129139471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129141601-129142508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20287 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129177967-129178559 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129183037-129183720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129185921-129186420 Neighboring gene uncharacterized LOC124902337 Neighboring gene non-coding repressor of NFAT Neighboring gene VISTA enhancer hs186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129214117-129214618 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:129236685-129237884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129238046-129238625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129238626-129239204 Neighboring gene Sharpr-MPRA regulatory region 3753 Neighboring gene Sharpr-MPRA regulatory region 6068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129270146-129270646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20288 Neighboring gene uncharacterized LOC105376276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129281950-129282456

    Genomic regions, transcripts, and products

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    Bibliography

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    Related articles in PubMed

    1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_117482.1 

      Range
      101..785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      126421442..126422126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      138627211..138627895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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