U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    LOC113788263 H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:142036197-142037048 and GRCh37_chr8:142037049-142037899 [ Homo sapiens (human) ]

    Gene ID: 113788263, updated on 10-Oct-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    LOC113788263
    Gene description
    H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:142036197-142037048 and GRCh37_chr8:142037049-142037899
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. Two subregions marked by the H3K27ac and H3K4me1 histone modifications were validated as active enhancers by ChIP-STARR-seq in naive human embryonic stem cells. An overlapping subregion was also validated as a functional enhancer by Sharpr-MPRA (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 5:Enh, candidate strong enhancer, open chromatin). [provided by RefSeq, Oct 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LOC113788263 in Genome Data Viewer
    Location:
    8q
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (141026098..141027800)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (142146197..142147900)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142036869..142037163)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine kinase 2 Neighboring gene microRNA 151a Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:141901324-141901954 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:141901955-141902583 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:141903275-141903488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141959143-141960131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28038 Neighboring gene RNA, 5S ribosomal pseudogene 278 Neighboring gene Sharpr-MPRA regulatory region 10587 Neighboring gene NANOG hESC enhancer GRCh37_chr8:141986399-141986923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142026737-142027298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142030905-142031616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142032328-142033038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142033039-142033749 Neighboring gene uncharacterized LOC105375783 Neighboring gene uncharacterized LOC124902030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047320-142047944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047945-142048570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142048571-142049195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142051549-142052338 Neighboring gene uncharacterized LOC105375784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142069799-142070496

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article
    2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See Variation Viewer (GRCh37.p13)

    General gene information

    Go to the top of the page Help

    Other Names

    • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142036197-142037048
    • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142037049-142037899
    • Sharpr-MPRA regulatory region 11335

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_062556.2 

      Range
      101..1803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      141026098..141027800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      142146197..142147900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases