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    LOC126807575 MED14-independent group 3 enhancer GRCh37_chr5:160365148-160366347 [ Homo sapiens (human) ]

    Gene ID: 126807575, updated on 10-Oct-2023

    Summary

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    Gene symbol
    LOC126807575
    Gene description
    MED14-independent group 3 enhancer GRCh37_chr5:160365148-160366347
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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    Genomic context

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    See LOC126807575 in Genome Data Viewer
    Location:
    chromosome: 5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (160938141..160939340)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (161467020..161468219)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159931865-159932702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16587 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23571 Neighboring gene MIR3142 host gene Neighboring gene microRNA 146a Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:160019382-160019882 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:160033047-160034246 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:160072012-160072167 Neighboring gene ATPase phospholipid transporting 10B (putative) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:160300808-160301385 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:160300229-160300807 Neighboring gene NANOG hESC enhancer GRCh37_chr5:160355657-160356158 Neighboring gene long intergenic non-protein coding RNA 2159 Neighboring gene uncharacterized LOC105377693 Neighboring gene NANOG hESC enhancer GRCh37_chr5:160535280-160535816 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:160616217-160616801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23574 Neighboring gene gamma-aminobutyric acid type A receptor subunit beta2 Neighboring gene uncharacterized LOC105377694

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_083889.1 

      Range
      101..1300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      160938141..160939340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      161467020..161468219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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