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    LOC126805617 MED14-independent group 3 enhancer GRCh37_chr1:10804287-10805486 [ Homo sapiens (human) ]

    Gene ID: 126805617, updated on 10-Oct-2023

    Summary

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    Gene symbol
    LOC126805617
    Gene description
    MED14-independent group 3 enhancer GRCh37_chr1:10804287-10805486
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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    Genomic context

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    Location:
    chromosome: 1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (10744230..10745429)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (10287823..10289094)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10534116-10535081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 247 Neighboring gene Sharpr-MPRA regulatory region 5895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 151 Neighboring gene DNA fragmentation factor subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 153 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10568725-10569413 Neighboring gene peroxisomal biogenesis factor 14 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:10588102-10589301 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10601005-10601548 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10616013-10616674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 248 Neighboring gene Sharpr-MPRA regulatory region 3136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10654141-10654658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10654659-10655176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10662571-10663072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10663073-10663572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10676275-10676958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10675589-10676274 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10678456-10679010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10682167-10682666 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:10683990-10685189 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10693091-10694054 Neighboring gene RNA, 7SL, cytoplasmic 614, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10695017-10695979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10706359-10706864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10715263-10715920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10719824-10720334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10720335-10720845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10724469-10725217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10725218-10725965 Neighboring gene VISTA enhancer hs289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10735694-10736484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10736485-10737273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10739643-10740432 Neighboring gene castor zinc finger 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10738853-10739642 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10746779-10747379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10746179-10746778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10761480-10761980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10763789-10764710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10765634-10766555 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10764711-10765633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10772353-10772897 Neighboring gene VISTA enhancer hs389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10787641-10788438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10788439-10789235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 253 Neighboring gene VISTA enhancer hs2094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10805585-10806508 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:10814763-10814950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10821512-10822012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10822013-10822513 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10845108-10845670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10845671-10846231 Neighboring gene VISTA enhancer hs408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10863938-10864510 Neighboring gene uncharacterized LOC105376733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10874119-10874619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10876704-10877204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10884509-10885026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10885027-10885544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10886063-10886578 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:10898203-10898810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10899993-10900493 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10920607-10921107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10921487-10921988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 254 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:10927921-10928792 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_081941.1 

      Range
      101..1300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      10744230..10745429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      10287823..10289094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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