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    CDK20 cyclin dependent kinase 20 [ Homo sapiens (human) ]

    Gene ID: 23552, updated on 2-May-2024

    Summary

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    Official Symbol
    CDK20provided by HGNC
    Official Full Name
    cyclin dependent kinase 20provided by HGNC
    Primary source
    HGNC:HGNC:21420
    See related
    Ensembl:ENSG00000156345 MIM:610076; AllianceGenome:HGNC:21420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P42; CCRK; CDCH; PNQALRE
    Summary
    The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]
    Expression
    Broad expression in testis (RPKM 10.2), adrenal (RPKM 7.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    9q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (87966441..87974533, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (100120474..100128570, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (90581356..90589448, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 598, E3 ubiquitin ligase pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90566553-90567406 Neighboring gene uncharacterized LOC122394732 Neighboring gene uncharacterized LOC124902200 Neighboring gene uncharacterized LOC105376131 Neighboring gene RNA, U6 small nuclear 86, pseudogene Neighboring gene ribosomal protein S10 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis. An X, et al. Eur J Cancer, 2010 Jun. PMID 20466538
    2. Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. Wu GQ, et al. Int J Cancer, 2009 Dec 1. PMID 19672860
    3. Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. Zhou J, et al. Gut, 2018 May. PMID 28939663, Free PMC Article
    4. A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients. Feng H, et al. J Hepatol, 2015 May. PMID 25500144
    5. The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity. Wohlbold L, et al. Cell Cycle, 2006 Mar. PMID 16552187

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Role of CDK20 Protein in Carcinogenesis.
      Title: The Role of CDK20 Protein in Carcinogenesis.
    2. BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1.
      Title: BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1.
    3. Results delineate an immunosuppressive mechanism of the hepatoma-intrinsic CCRK signalling and highlight an overexpressed kinase target whose inhibition might empower hepatocellular carcinoma immunotherapy
      Title: Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.
    4. A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patient.
      Title: A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients.
    5. In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation.
      Title: CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner.
    6. Data indicate that expression of ERAS, LHX1, and CCRK is increased in aggressive subgroups of medulloblastomas.
      Title: Functional genomics identifies drivers of medulloblastoma dissemination.
    7. Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives beta-catenin/T cell factor-dependent hepatocarcinogenesis
      Title: Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives β-catenin/T cell factor-dependent hepatocarcinogenesis.
    8. results suggest for the first time that CCRK is involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2, cyclin E and Rb.
      Title: Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis.
    9. Overexpression of CCRK is associated with ovarian carcinoma.
      Title: Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma.
    10. Depletion of PNQALRE by >80% due to RNA interference (RNAi) impairs cell proliferation, but fails to arrest the cell cycle at a discrete point.
      Title: The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic camera-type eye development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in floor plate formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 20
    Names
    CAK-kinase p42
    CDK-activating kinase p42
    cell cycle-related kinase
    cell division protein kinase 20
    cyclin-dependent protein kinase H
    cyclin-kinase-activating kinase p42
    NP_001034892.1
    NP_001164110.1
    NP_001164111.1
    NP_036251.2
    NP_848519.1
    XP_016870050.1
    XP_016870051.1
    XP_016870052.1
    XP_016870053.1
    XP_047279074.1
    XP_047279075.1
    XP_047279076.1
    XP_047279077.1
    XP_047279078.1
    XP_047279080.1
    XP_047279081.1
    XP_054218535.1
    XP_054218536.1
    XP_054218537.1
    XP_054218538.1
    XP_054218539.1
    XP_054218540.1
    XP_054218541.1
    XP_054218542.1
    XP_054218543.1
    XP_054218544.1
    XP_054218545.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039803.3 → NP_001034892.1  cyclin-dependent kinase 20 isoform 3

      See identical proteins and their annotated locations for NP_001034892.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and contains an alternate, in-frame exon in the middle portion of the coding region, compared to variant 1. This results in a longer protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AI479563, AL353572, BM982394
      Consensus CDS
      CCDS35060.1
      UniProtKB/Swiss-Prot
      A2A389, A2A390, B4DQX1, O95137, Q5EDC4, Q5VYW1, Q8IZL9, Q9BUF4
      UniProtKB/TrEMBL
      A0A0S2Z557
      Related
      ENSP00000322343.8, ENST00000325303.9
      Conserved Domains (2) summary
      PLN00009
      Location:1 → 288
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07832
      Location:3 → 289
      STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

    2. NM_001170639.2 → NP_001164110.1  cyclin-dependent kinase 20 isoform 4

      See identical proteins and their annotated locations for NP_001164110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, and an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AI479563, AK075325, AL353572, AY904367, BC002655, BM982394, CB992644
      Consensus CDS
      CCDS65075.1
      UniProtKB/TrEMBL
      A0A0S2Z566, A0A0S2Z5B6
      Related
      ENSP00000474485.1, ENST00000605159.5
      Conserved Domains (1) summary
      cd07832
      Location:3 → 273
      STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

    3. NM_001170640.2 → NP_001164111.1  cyclin-dependent kinase 20 isoform 5

      See identical proteins and their annotated locations for NP_001164111.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, and lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform 5, also known as cardiac CCRK), compared to isoform 1.
      Source sequence(s)
      AI479563, AK075325, AL353572, AY904367, BM982394, CB992644
      Consensus CDS
      CCDS55324.1
      UniProtKB/TrEMBL
      A0A0S2Z535
      Related
      ENSP00000365031.3, ENST00000375871.8
      Conserved Domains (2) summary
      smart00220
      Location:4 → 167
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:3 → 167
      PKc_like; Protein Kinases, catalytic domain

    4. NM_012119.5 → NP_036251.2  cyclin-dependent kinase 20 isoform 2

      See identical proteins and their annotated locations for NP_036251.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AI479563, AK075325, AL353572, AY904367, BM982394, CB992644
      Consensus CDS
      CCDS6677.1
      UniProtKB/TrEMBL
      A0A0S2Z566
      Related
      ENSP00000365043.3, ENST00000375883.7
      Conserved Domains (2) summary
      PLN00009
      Location:1 → 267
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07832
      Location:3 → 268
      STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

    5. NM_178432.4 → NP_848519.1  cyclin-dependent kinase 20 isoform 1

      See identical proteins and their annotated locations for NP_848519.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AI479563, AK075325, AL353572, AY904367, BM982394, CB992644
      Consensus CDS
      CCDS6678.1
      UniProtKB/TrEMBL
      A0A0S2Z566
      Related
      ENSP00000338975.5, ENST00000336654.9
      Conserved Domains (2) summary
      PLN00009
      Location:1 → 280
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07832
      Location:3 → 281
      STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      87966441..87974533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014563.3 → XP_016870052.1  cyclin-dependent kinase 20 isoform X8

    2. XM_017014564.3 → XP_016870053.1  cyclin-dependent kinase 20 isoform X9

      UniProtKB/TrEMBL
      A0A0S2Z562, A0A0S2Z566
      Conserved Domains (2) summary
      PLN00009
      Location:1 → 259
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07832
      Location:3 → 260
      STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

    3. XM_047423121.1 → XP_047279077.1  cyclin-dependent kinase 20 isoform X6

    4. XM_017014561.3 → XP_016870050.1  cyclin-dependent kinase 20 isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z557

    5. XM_017014562.3 → XP_016870051.1  cyclin-dependent kinase 20 isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z557

    6. XM_047423124.1 → XP_047279080.1  cyclin-dependent kinase 20 isoform X10

    7. XM_047423122.1 → XP_047279078.1  cyclin-dependent kinase 20 isoform X7

    8. XM_047423119.1 → XP_047279075.1  cyclin-dependent kinase 20 isoform X2

    9. XM_047423118.1 → XP_047279074.1  cyclin-dependent kinase 20 isoform X1

    10. XM_047423120.1 → XP_047279076.1  cyclin-dependent kinase 20 isoform X4

    11. XM_047423125.1 → XP_047279081.1  cyclin-dependent kinase 20 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      100120474..100128570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362567.1 → XP_054218542.1  cyclin-dependent kinase 20 isoform X8

    2. XM_054362568.1 → XP_054218543.1  cyclin-dependent kinase 20 isoform X9

    3. XM_054362565.1 → XP_054218540.1  cyclin-dependent kinase 20 isoform X6

    4. XM_054362562.1 → XP_054218537.1  cyclin-dependent kinase 20 isoform X3

    5. XM_054362564.1 → XP_054218539.1  cyclin-dependent kinase 20 isoform X5

    6. XM_054362569.1 → XP_054218544.1  cyclin-dependent kinase 20 isoform X10

    7. XM_054362566.1 → XP_054218541.1  cyclin-dependent kinase 20 isoform X7

    8. XM_054362561.1 → XP_054218536.1  cyclin-dependent kinase 20 isoform X2

    9. XM_054362560.1 → XP_054218535.1  cyclin-dependent kinase 20 isoform X1

    10. XM_054362563.1 → XP_054218538.1  cyclin-dependent kinase 20 isoform X4

    11. XM_054362570.1 → XP_054218545.1  cyclin-dependent kinase 20 isoform X11

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZL9.1 GenPept UniProtKB/Swiss-Prot:Q8IZL9

    Gene LinkOut

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