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    CENPK centromere protein K [ Homo sapiens (human) ]

    Gene ID: 64105, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CENPKprovided by HGNC
    Official Full Name
    centromere protein Kprovided by HGNC
    Primary source
    HGNC:HGNC:29479
    See related
    Ensembl:ENSG00000123219 MIM:611502; AllianceGenome:HGNC:29479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P33; Solt; CENP-K; FKSG14; AF5alpha
    Summary
    CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 1.8), bone marrow (RPKM 1.7) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CENPK in Genome Data Viewer
    Location:
    5q12.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (65495624..65563168, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (66338058..66384928, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (64812119..64858995, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 6 Neighboring gene ribosomal protein S2 pseudogene 23 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:64777627-64778126 Neighboring gene uncharacterized LOC124900986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:64780998-64781506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:64781507-64782013 Neighboring gene MPRA-validated peak5269 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:64855281-64855780 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:64858250-64858911 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:64858912-64859572 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene RNA, U6 small nuclear 540, pseudogene Neighboring gene tripartite motif containing 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling. Li G, et al. Mol Cell Endocrinol, 2024 Aug 1. PMID 38670220
    2. Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration. Li Q, et al. Bioengineered, 2021 Dec. PMID 33904381, Free PMC Article
    3. Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia. Taki T, et al. Oncogene, 1996 Nov 21. PMID 8950979
    4. Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A. Li X, et al. World J Gastroenterol, 2022 Oct 7. PMID 36312839, Free PMC Article
    5. Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5. Tian H, et al. Gastric Cancer, 2022 Sep. PMID 35715658

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling.
      Title: CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling.
    2. Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A.
      Title: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A.
    3. Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
      Title: Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.
    4. N(6)-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance.
      Title: N(6)-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance.
    5. Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration.
      Title: Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration.
    6. the vertebrate KNL1 counterpart is essential for chromosome segregation and is required to localize a subset of outer kinetochore proteins.
      Title: KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of centromere protein K (CENPK) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of inner kinetochore IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein K
    Names
    SoxLZ/Sox6-binding protein Solt
    interphase centromere complex protein 37
    leucine zipper protein FKSG14
    protein AF-5alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267038.2 → NP_001253967.1  centromere protein K isoform 1

      See identical proteins and their annotated locations for NP_001253967.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC005400, BC008504, BG502832
      Consensus CDS
      CCDS3984.1
      UniProtKB/Swiss-Prot
      Q9BS16, Q9H4L0
      Related
      ENSP00000422421.1, ENST00000514814.5
      Conserved Domains (1) summary
      pfam11802
      Location:10 → 269
      CENP-K; Centromere-associated protein K

    2. NM_001349367.2 → NP_001336296.1  centromere protein K isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in its 5' coding region, resulting in use of an alternate start codon, compared to variant 1. The encoded isoform (3) has a slightly longer, but distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BC005400, BC008504, BG502832, BG527280
      Conserved Domains (1) summary
      pfam11802
      Location:12 → 271
      CENP-K; Centromere-associated protein K

    3. NM_001349368.2 → NP_001336297.1  centromere protein K isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and lacks an alternate in-frame exon in its central coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus and lacks an internal segment compared to isoform 1.
      Source sequence(s)
      BC005400, BC008504, BF211376, BG502832, BG505115
      Consensus CDS
      CCDS87299.1
      UniProtKB/TrEMBL
      D6RJF0
      Related
      ENSP00000425686.1, ENST00000510693.5
      Conserved Domains (1) summary
      pfam11802
      Location:1 → 206
      CENP-K; Centromere-associated protein K

    4. NM_001349369.2 → NP_001336298.1  centromere protein K isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and contains an alternate terminal exon, resulting in a novel 3' coding region, compared to variant 1. The encoded isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC016620, BC005400, BG502832, BG505115
      Conserved Domains (1) summary
      pfam11802
      Location:1 → 189
      CENP-K; Centromere-associated protein K

    5. NM_022145.5 → NP_071428.2  centromere protein K isoform 1

      See identical proteins and their annotated locations for NP_071428.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC008504
      Consensus CDS
      CCDS3984.1
      UniProtKB/Swiss-Prot
      Q9BS16, Q9H4L0
      Related
      ENSP00000379911.1, ENST00000396679.6
      Conserved Domains (1) summary
      pfam11802
      Location:10 → 269
      CENP-K; Centromere-associated protein K

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      65495624..65563168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009696.3 → XP_016865185.1  centromere protein K isoform X7

    2. XM_047417488.1 → XP_047273444.1  centromere protein K isoform X12

    3. XM_047417485.1 → XP_047273441.1  centromere protein K isoform X8

    4. XM_047417487.1 → XP_047273443.1  centromere protein K isoform X11

    5. XM_017009695.2 → XP_016865184.1  centromere protein K isoform X5

    6. XM_011543538.3 → XP_011541840.1  centromere protein K isoform X4

      Conserved Domains (1) summary
      pfam11802
      Location:12 → 238
      CENP-K; Centromere-associated protein K

    7. XM_024446148.2 → XP_024301916.1  centromere protein K isoform X14

      Conserved Domains (1) summary
      pfam11802
      Location:18 → 172
      CENP-K; Centromere-associated protein K

    8. XM_011543541.3 → XP_011541843.1  centromere protein K isoform X10

      See identical proteins and their annotated locations for XP_011541843.1

      Conserved Domains (1) summary
      pfam11802
      Location:18 → 205
      CENP-K; Centromere-associated protein K

    9. XM_047417480.1 → XP_047273436.1  centromere protein K isoform X1

    10. XM_024446145.2 → XP_024301913.1  centromere protein K isoform X10

      Conserved Domains (1) summary
      pfam11802
      Location:18 → 205
      CENP-K; Centromere-associated protein K

    11. XM_047417486.1 → XP_047273442.1  centromere protein K isoform X9

    12. XM_047417481.1 → XP_047273437.1  centromere protein K isoform X1

    13. XM_011543542.3 → XP_011541844.1  centromere protein K isoform X10

      See identical proteins and their annotated locations for XP_011541844.1

      Conserved Domains (1) summary
      pfam11802
      Location:18 → 205
      CENP-K; Centromere-associated protein K

    14. XM_011543535.3 → XP_011541837.1  centromere protein K isoform X1

      See identical proteins and their annotated locations for XP_011541837.1

      Conserved Domains (1) summary
      pfam11802
      Location:12 → 271
      CENP-K; Centromere-associated protein K

    15. XM_047417484.1 → XP_047273440.1  centromere protein K isoform X6

    16. XM_017009692.2 → XP_016865181.1  centromere protein K isoform X2

      UniProtKB/Swiss-Prot
      Q9BS16, Q9H4L0
      Conserved Domains (1) summary
      pfam11802
      Location:10 → 269
      CENP-K; Centromere-associated protein K

    17. XM_047417483.1 → XP_047273439.1  centromere protein K isoform X3

      UniProtKB/TrEMBL
      D6RHD3

    18. XM_017009690.2 → XP_016865179.1  centromere protein K isoform X2

      UniProtKB/Swiss-Prot
      Q9BS16, Q9H4L0
      Conserved Domains (1) summary
      pfam11802
      Location:10 → 269
      CENP-K; Centromere-associated protein K

    19. XM_017009694.2 → XP_016865183.1  centromere protein K isoform X3

      UniProtKB/TrEMBL
      D6RHD3
      Conserved Domains (1) summary
      pfam11802
      Location:1 → 239
      CENP-K; Centromere-associated protein K

    20. XM_011543536.3 → XP_011541838.1  centromere protein K isoform X2

      See identical proteins and their annotated locations for XP_011541838.1

      UniProtKB/Swiss-Prot
      Q9BS16, Q9H4L0
      Conserved Domains (1) summary
      pfam11802
      Location:10 → 269
      CENP-K; Centromere-associated protein K

    21. XM_047417489.1 → XP_047273445.1  centromere protein K isoform X13

    RNA

    1. XR_007058619.1 RNA Sequence

    2. XR_007058618.1 RNA Sequence

    3. XR_007058617.1 RNA Sequence

    4. XR_001742177.2 RNA Sequence

    5. XR_007058615.1 RNA Sequence

    6. XR_007058616.1 RNA Sequence

    7. XR_948282.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      66338058..66384928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353074.1 → XP_054209049.1  centromere protein K isoform X12

    2. XM_054353068.1 → XP_054209043.1  centromere protein K isoform X15

    3. XM_054353069.1 → XP_054209044.1  centromere protein K isoform X8

    4. XM_054353073.1 → XP_054209048.1  centromere protein K isoform X11

    5. XM_054353066.1 → XP_054209041.1  centromere protein K isoform X5

    6. XM_054353065.1 → XP_054209040.1  centromere protein K isoform X4

    7. XM_054353076.1 → XP_054209051.1  centromere protein K isoform X14

    8. XM_054353070.1 → XP_054209045.1  centromere protein K isoform X10

    9. XM_054353071.1 → XP_054209046.1  centromere protein K isoform X10

    10. XM_054353072.1 → XP_054209047.1  centromere protein K isoform X10

    11. XM_054353067.1 → XP_054209042.1  centromere protein K isoform X6

    12. XM_054353061.1 → XP_054209036.1  centromere protein K isoform X1

    13. XM_054353063.1 → XP_054209038.1  centromere protein K isoform X2

      UniProtKB/Swiss-Prot
      Q9BS16, Q9H4L0

    14. XM_054353062.1 → XP_054209037.1  centromere protein K isoform X2

      UniProtKB/Swiss-Prot
      Q9BS16, Q9H4L0

    15. XM_054353064.1 → XP_054209039.1  centromere protein K isoform X3

      UniProtKB/TrEMBL
      D6RHD3

    16. XM_054353075.1 → XP_054209050.1  centromere protein K isoform X13

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BS16.1 GenPept UniProtKB/Swiss-Prot:Q9BS16

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