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    GGNBP2 gametogenetin binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 79893, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GGNBP2provided by HGNC
    Official Full Name
    gametogenetin binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:19357
    See related
    Ensembl:ENSG00000278311 MIM:612275; AllianceGenome:HGNC:19357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIF3; LZK1; DIF-3; LCRG1; ZFP403; ZNF403
    Summary
    Predicted to be involved in spermatogenesis. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of cell population proliferation; and negative regulation of protein phosphorylation. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 42.4), bone marrow (RPKM 29.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GGNBP2 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (36544919..36589848)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (37530672..37576192)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34900768..34946278)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 439 Neighboring gene zinc finger HIT-type containing 3 Neighboring gene myosin XIX Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:34889386-34890061 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class W Neighboring gene ribosomal protein S2 pseudogene 50 Neighboring gene uncharacterized LOC107985031 Neighboring gene dehydrogenase/reductase 11 Neighboring gene mitochondrial rRNA methyltransferase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34983260-34983760

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930. Li Y, et al. Cancer Lett, 2004 Jun 8. PMID 15145523
    2. Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators. Guan R, et al. Mol Cell Biochem, 2012 Jun. PMID 22350815
    3. Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells. Xu X, et al. Oncol Rep, 2020 Dec. PMID 33125130, Free PMC Article
    4. Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells. Yang Z, et al. Andrologia, 2020 Mar. PMID 31797427
    5. ZFP403, a novel tumor suppressor, inhibits the proliferation and metastasis in ovarian cancer. Zhu Z, et al. Gynecol Oncol, 2017 Nov. PMID 28864131

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.
      Title: Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.
    2. Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells.
      Title: Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells.
    3. Our data demonstrate that GGNBP2 suppresses cancer aggressiveness by inhibition of IL-6/STAT3 activation in triple-negative breast cancer
      Title: GGNBP2 suppresses triple-negative breast cancer aggressiveness through inhibition of IL-6/STAT3 signaling activation.
    4. Results identified GGNBP2 as a novel tumor suppressor which is downregulated in human breast tumors and cell lines and suggest that GGNBP2 may function as a corepressor to inhibit ERa's transcriptional activity and consequently inhibit tumorigenic potential of breast cancer cells.
      Title: GGNBP2 acts as a tumor suppressor by inhibiting estrogen receptor α activity in breast cancer cells.
    5. The effects of ZFP403 on cell proliferation and metastasis suggest that it may serve as a tumor suppressor in ovarian cancer.
      Title: ZFP403, a novel tumor suppressor, inhibits the proliferation and metastasis in ovarian cancer.
    6. Results show that downregulation of RNASET2 and GGNBP2 in drug-resistant ovarian cancer tissues/cells contributes to the regulation of drug resistance in ovarian cancer.
      Title: Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer.
    7. There is an essential role for ZNF403 in cell proliferation and G2/M cell-cycle transition.
      Title: Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators.
    8. LCRG1 is a novel gene localized to the tumor suppressor locus D17S800-D17S930 involved in laryngeal carcinoma.
      Title: Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21230, FLJ22561, FLJ42090

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in labyrinthine layer blood vessel development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gametogenetin-binding protein 2
    Names
    C3HC4-type zinc finger protein
    laryngeal carcinoma related gene 1
    laryngeal carcinoma-related protein 1
    zinc finger protein 403

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024835.5 → NP_079111.1  gametogenetin-binding protein 2

      See identical proteins and their annotated locations for NP_079111.1

      Status: VALIDATED

      Source sequence(s)
      AF126964, BC137491, DA494492
      Consensus CDS
      CCDS11314.1
      UniProtKB/Swiss-Prot
      B2RPK7, Q96T90, Q9GZR8, Q9H3C7, Q9H767
      UniProtKB/TrEMBL
      A8K3S2
      Related
      ENSP00000478220.1, ENST00000613102.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      36544919..36589848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257689.4 → XP_005257746.1  gametogenetin-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005257746.1

      UniProtKB/TrEMBL
      A8K3S2

    2. XM_011525266.3 → XP_011523568.1  gametogenetin-binding protein 2 isoform X4

      See identical proteins and their annotated locations for XP_011523568.1

      UniProtKB/TrEMBL
      A8K3S2

    3. XM_047436774.1 → XP_047292730.1  gametogenetin-binding protein 2 isoform X5

    4. XM_011525265.4 → XP_011523567.1  gametogenetin-binding protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011523567.1

      UniProtKB/TrEMBL
      A8K3S2

    5. XM_017025107.2 → XP_016880596.1  gametogenetin-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A8K3S2

    6. XM_047436775.1 → XP_047292731.1  gametogenetin-binding protein 2 isoform X6

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      779823..825343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329335.1 → XP_054185310.1  gametogenetin-binding protein 2 isoform X1

    2. XM_054329338.1 → XP_054185313.1  gametogenetin-binding protein 2 isoform X4

    3. XM_054329339.1 → XP_054185314.1  gametogenetin-binding protein 2 isoform X5

    4. XM_054329336.1 → XP_054185311.1  gametogenetin-binding protein 2 isoform X2

    5. XM_054329337.1 → XP_054185312.1  gametogenetin-binding protein 2 isoform X3

    6. XM_054329340.1 → XP_054185315.1  gametogenetin-binding protein 2 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      37530672..37576192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317271.1 → XP_054173246.1  gametogenetin-binding protein 2 isoform X1

    2. XM_054317274.1 → XP_054173249.1  gametogenetin-binding protein 2 isoform X4

    3. XM_054317275.1 → XP_054173250.1  gametogenetin-binding protein 2 isoform X5

    4. XM_054317272.1 → XP_054173247.1  gametogenetin-binding protein 2 isoform X2

    5. XM_054317273.1 → XP_054173248.1  gametogenetin-binding protein 2 isoform X3

    6. XM_054317276.1 → XP_054173251.1  gametogenetin-binding protein 2 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H3C7.1 GenPept UniProtKB/Swiss-Prot:Q9H3C7

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