RNF112 ring finger protein 112 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RNF112provided by HGNC
Official Full Name: ring finger protein 112provided by HGNC
Primary source: HGNC:HGNC:12968
See related: Ensembl:ENSG00000128482 MIM:601237; AllianceGenome:HGNC:12968
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BFP; ZNF179
Summary: This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 6.0), prostate (RPKM 2.1) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p11.2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (19411232..19417276)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (19359261..19365304)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (19314545..19320589)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer.
Title: RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer.
Znf179 can reprogram glioblastoma multiforme cells into a more-differentiated phenotype and prevent the progression of gliomas to a more-malignant state through p53-mediated cell-cycle signaling pathways.
Title: Znf179 induces differentiation and growth arrest of human primary glioblastoma multiforme in a p53-dependent cell cycle pathway.
Plzf was identified as a specific interacting protein of Znf179; the region containing the first two zinc fingers is critical for its interaction with Znf179. Cellular localization of Znf179 changed from cytoplasm to nucleus when Plzf was co-expressed.
Title: Analysis of the interaction between Zinc finger protein 179 (Znf179) and promyelocytic leukemia zinc finger (Plzf).

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G1 to G0 transition involved in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in embryonic brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hydroperoxide	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: RING finger protein 112

Names: brain finger protein; neurolastin; zinc finger protein 179

NP_009079.2

EC 2.3.2.27

XP_006721634.1

EC 2.3.2.27

XP_006721635.1

EC 2.3.2.27

XP_006721636.1

EC 2.3.2.27

XP_047292622.1

EC 2.3.2.27

XP_047292623.1

EC 2.3.2.27

XP_054173048.1

EC 2.3.2.27

XP_054173049.1

EC 2.3.2.27

XP_054173050.1

EC 2.3.2.27

XP_054173051.1

EC 2.3.2.27

XP_054173052.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007148.5 → NP_009079.2 RING finger protein 112

See identical proteins and their annotated locations for NP_009079.2

Status: REVIEWED

Source sequence(s)

BC053989, BE297851

Consensus CDS

CCDS58529.1

UniProtKB/Swiss-Prot

O60633, Q7Z5V9, Q9ULX5

Related

ENSP00000454919.1, ENST00000461366.2

Conserved Domains (2) summary

cd01851
Location:163 → 394

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cl17238
Location:55 → 102

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

19411232..19417276

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006721571.5 → XP_006721634.1 RING finger protein 112 isoform X1

Conserved Domains (2) summary

cd01851
Location:163 → 402

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd00162
Location:56 → 101

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_006721572.5 → XP_006721635.1 RING finger protein 112 isoform X2

Conserved Domains (2) summary

cd01851
Location:162 → 401

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd00162
Location:56 → 101

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_047436666.1 → XP_047292622.1 RING finger protein 112 isoform X4
XM_006721573.3 → XP_006721636.1 RING finger protein 112 isoform X3

Conserved Domains (2) summary

cd01851
Location:139 → 378

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd00162
Location:32 → 77

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_047436667.1 → XP_047292623.1 RING finger protein 112 isoform X5