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    KRT23 keratin 23 [ Homo sapiens (human) ]

    Gene ID: 25984, updated on 3-Nov-2024

    Summary

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    Official Symbol
    KRT23provided by HGNC
    Official Full Name
    keratin 23provided by HGNC
    Primary source
    HGNC:HGNC:6438
    See related
    Ensembl:ENSG00000108244 MIM:606194; AllianceGenome:HGNC:6438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K23; CK23; HAIK1
    Summary
    The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Biased expression in placenta (RPKM 45.8), skin (RPKM 39.5) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KRT23 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40922700..40937646, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41787032..41801979, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39078952..39093898, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371777 Neighboring gene keratin 12 Neighboring gene keratin 20 Neighboring gene uncharacterized LOC107985072 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:39109689-39110888 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:39112787-39113986 Neighboring gene keratin 39 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:39136258-39136859 Neighboring gene keratin 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells. Birkenkamp-Demtröder K, et al. PLoS One, 2013. PMID 24039993, Free PMC Article
    2. Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro. Birkenkamp-Demtroder K, et al. Mol Oncol, 2007 Sep. PMID 19383294, Free PMC Article
    3. Immune checkpoint gene signature assesses immune infiltration profiles in bladder cancer and identifies KRT23 as an immunotherapeutic target. Chen D, et al. BMC Cancer, 2024 Aug 19. PMID 39160525, Free PMC Article
    4. Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function. Tolstonog GV, et al. DNA Cell Biol, 2002 Mar. PMID 12015898
    5. Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver. Kinast V, et al. Cells, 2019 Jun 18. PMID 31216713, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Immune checkpoint gene signature assesses immune infiltration profiles in bladder cancer and identifies KRT23 as an immunotherapeutic target.
      Title: Immune checkpoint gene signature assesses immune infiltration profiles in bladder cancer and identifies KRT23 as an immunotherapeutic target.
    2. The Overexpression of Keratin 23 Promotes Migration of Ovarian Cancer via Epithelial-Mesenchymal Transition.
      Title: The Overexpression of Keratin 23 Promotes Migration of Ovarian Cancer via Epithelial-Mesenchymal Transition.
    3. highly elevated in hepatocellular carcinoma
      Title: Keratin 23 Is a Peroxisome Proliferator-Activated Receptor Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte Proliferation.
    4. AUthors investigated KRT23 mRNA levels in datasets from liver biopsies of chronic hepatitis C (CHC) patients and in primary human hepatocytes experimentally infected with HCV, in addition to hepatoma cells. In each of these specimens, we observed an HCV-dependent increase of mRNA levels. Importantly, the KRT23 protein levels in patient plasma decreased upon viral clearance.
      Title: Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver.
    5. transcriptome studies identified keratin 23 as a new ductular cell marker in patients with alcoholic hepatitis
      Title: LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis.
    6. Data show that Keratin23 (KRT23) knockdown affected molecules of the cell cycle and DNA replication, recombination and repair.
      Title: Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells.
    7. Increased expression of KRT23 is associated with colorectal cancer.
      Title: Identification of putative immunologic targets for colon cancer prevention based on conserved gene upregulation from preinvasive to malignant lesions.
    8. Data suggest a regulatory circuitry involving Smad4 dependent up-regulation of KRT23 (directly or indirectly) which in turn modulates the interaction between KRT23 and 14-3-3epsilon leading to a cytoplasmic sequestration of 14-3-3epsilon.
      Title: Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε.
    9. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
    10. Keratin23 expression is a novel and important difference between microsatellite-stable and microsatellite-instable colon cancers.
      Title: Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 15 loci influencing height in a Korean population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26158, DKFZp434G032

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cytoskeletal 23
    Names
    CK-23
    cytokeratin 23
    histone deacetylase inducible keratin 23
    hyperacetylation-inducible type I keratin
    keratin 23 (histone deacetylase inducible)
    keratin 23, type I
    type I intermediate filament cytokeratin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012287.1 RefSeqGene

      Range
      4939..19885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282433.2 → NP_001269362.1  keratin, type I cytoskeletal 23 isoform 2

      See identical proteins and their annotated locations for NP_001269362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK302109, CV373638
      Consensus CDS
      CCDS62182.1
      UniProtKB/Swiss-Prot
      Q9C075
      Related
      ENSP00000414056.3, ENST00000436344.7
      Conserved Domains (1) summary
      pfam00038
      Location:3 → 243
      Filament; Intermediate filament protein

    2. NM_015515.5 → NP_056330.3  keratin, type I cytoskeletal 23 isoform 1

      See identical proteins and their annotated locations for NP_056330.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the larger isoform (1)
      Source sequence(s)
      AA649738, AC004231, BC028356, DA846104
      Consensus CDS
      CCDS11380.1
      UniProtKB/Swiss-Prot
      A8K084, B7Z7J2, I3L3Q6, Q9C075, Q9NUR6
      UniProtKB/TrEMBL
      Q8TC04
      Related
      ENSP00000209718.3, ENST00000209718.8
      Conserved Domains (1) summary
      pfam00038
      Location:71 → 380
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      40922700..40937646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257200.6 → XP_005257257.1  keratin, type I cytoskeletal 23 isoform X2

      See identical proteins and their annotated locations for XP_005257257.1

      UniProtKB/Swiss-Prot
      Q9C075
      Conserved Domains (1) summary
      pfam00038
      Location:3 → 243
      Filament; Intermediate filament protein

    2. XM_047435728.1 → XP_047291684.1  keratin, type I cytoskeletal 23 isoform X1

      UniProtKB/Swiss-Prot
      A8K084, B7Z7J2, I3L3Q6, Q9C075, Q9NUR6

    3. XM_047435729.1 → XP_047291685.1  keratin, type I cytoskeletal 23 isoform X1

      UniProtKB/Swiss-Prot
      A8K084, B7Z7J2, I3L3Q6, Q9C075, Q9NUR6

    4. XM_047435727.1 → XP_047291683.1  keratin, type I cytoskeletal 23 isoform X1

      UniProtKB/Swiss-Prot
      A8K084, B7Z7J2, I3L3Q6, Q9C075, Q9NUR6

    5. XM_047435726.1 → XP_047291682.1  keratin, type I cytoskeletal 23 isoform X1

      UniProtKB/Swiss-Prot
      A8K084, B7Z7J2, I3L3Q6, Q9C075, Q9NUR6

    6. XM_011524595.3 → XP_011522897.1  keratin, type I cytoskeletal 23 isoform X2

      See identical proteins and their annotated locations for XP_011522897.1

      UniProtKB/Swiss-Prot
      Q9C075
      Conserved Domains (1) summary
      pfam00038
      Location:3 → 243
      Filament; Intermediate filament protein

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003871091.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      71968..86914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329715.1 → XP_054185690.1  keratin, type I cytoskeletal 23 isoform X2

    2. XM_054329712.1 → XP_054185687.1  keratin, type I cytoskeletal 23 isoform X1

      UniProtKB/Swiss-Prot
      A8K084, B7Z7J2, I3L3Q6, Q9C075, Q9NUR6

    3. XM_054329713.1 → XP_054185688.1  keratin, type I cytoskeletal 23 isoform X1

      UniProtKB/Swiss-Prot
      A8K084, B7Z7J2, I3L3Q6, Q9C075, Q9NUR6

    4. XM_054329711.1 → XP_054185686.1  keratin, type I cytoskeletal 23 isoform X1

      UniProtKB/Swiss-Prot
      A8K084, B7Z7J2, I3L3Q6, Q9C075, Q9NUR6

    5. XM_054329710.1 → XP_054185685.1  keratin, type I cytoskeletal 23 isoform X1

      UniProtKB/Swiss-Prot
      A8K084, B7Z7J2, I3L3Q6, Q9C075, Q9NUR6

    6. XM_054329709.1 → XP_054185684.1  keratin, type I cytoskeletal 23 isoform X1

      UniProtKB/Swiss-Prot
      A8K084, B7Z7J2, I3L3Q6, Q9C075, Q9NUR6

    7. XM_054329714.1 → XP_054185689.1  keratin, type I cytoskeletal 23 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      41787032..41801979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315674.1 → XP_054171649.1  keratin, type I cytoskeletal 23 isoform X2

    2. XM_054315671.1 → XP_054171646.1  keratin, type I cytoskeletal 23 isoform X1

    3. XM_054315672.1 → XP_054171647.1  keratin, type I cytoskeletal 23 isoform X1

    4. XM_054315670.1 → XP_054171645.1  keratin, type I cytoskeletal 23 isoform X1

    5. XM_054315669.1 → XP_054171644.1  keratin, type I cytoskeletal 23 isoform X1

    6. XM_054315673.1 → XP_054171648.1  keratin, type I cytoskeletal 23 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173213.1: Suppressed sequence

      Description
      NM_173213.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C075.2 GenPept UniProtKB/Swiss-Prot:Q9C075

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