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    DPEP2 dipeptidase 2 [ Homo sapiens (human) ]

    Gene ID: 64174, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DPEP2provided by HGNC
    Official Full Name
    dipeptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:23028
    See related
    Ensembl:ENSG00000167261 MIM:609925; AllianceGenome:HGNC:23028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MBD2
    Summary
    DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in spleen (RPKM 6.2), lymph node (RPKM 3.2) and 14 other tissues See more
    Orthologs
    all
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    Genomic context

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    See DPEP2 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67987390..68000619, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73783178..73796408, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68021293..68034522, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene lecithin-cholesterol acyltransferase Neighboring gene solute carrier family 12 member 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:67992978-67994177 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67998939-67999110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68000156-68000674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68013726-68014226 Neighboring gene dipeptidase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7636 Neighboring gene Sharpr-MPRA regulatory region 6452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68031810-68032326 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:68040489-68041262 Neighboring gene lysyl-tRNA synthetase 1 pseudogene 3 Neighboring gene DPEP2 neighbor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Dipeptidase‑2 is a prognostic marker in lung adenocarcinoma that is correlated with its sensitivity to cisplatin. Wang Y, et al. Oncol Rep, 2023 Aug. PMID 37449493, Free PMC Article
    2. Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity. Hayashi K, et al. J Struct Biol, 2020 Jul 1. PMID 32325220
    3. Identification of two additional members of the membrane-bound dipeptidase family. Habib GM, et al. FASEB J, 2003 Jul. PMID 12738806
    4. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Willer CJ, et al. Nat Genet, 2008 Feb. PMID 18193043, Free PMC Article
    5. Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism. Shen C, et al. J Mol Neurosci, 2015 May. PMID 25464930

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dipeptidase-2 is a prognostic marker in lung adenocarcinoma that is correlated with its sensitivity to cisplatin.
      Title: Dipeptidase‑2 is a prognostic marker in lung adenocarcinoma that is correlated with its sensitivity to cisplatin.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in leukotriene D4 catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leukotriene metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidase 2
    NP_001311088.1
    NP_001356586.1
    NP_071750.1
    XP_005256147.2
    XP_011521568.1
    XP_011521570.1
    XP_011521573.1
    XP_011521575.1
    XP_011521576.1
    XP_016879034.1
    XP_016879036.1
    XP_024306140.1
    XP_024306141.1
    XP_024306142.1
    XP_024306144.1
    XP_047290415.1
    XP_047290416.1
    XP_047290417.1
    XP_047290418.1
    XP_047290419.1
    XP_047290420.1
    XP_047290421.1
    XP_054169597.1
    XP_054169598.1
    XP_054169599.1
    XP_054169600.1
    XP_054169601.1
    XP_054169602.1
    XP_054169603.1
    XP_054169604.1
    XP_054169605.1
    XP_054169606.1
    XP_054169607.1
    XP_054169608.1
    XP_054169609.1
    XP_054169610.1
    XP_054169611.1
    XP_054169612.1
    XP_054169613.1
    XP_054169614.1
    XP_054169615.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324159.2 → NP_001311088.1  dipeptidase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC040162, KC877614
      Conserved Domains (1) summary
      pfam01244
      Location:1 → 241
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    2. NM_001369657.1 → NP_001356586.1  dipeptidase 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC040162, KC877614
      Consensus CDS
      CCDS10857.1
      UniProtKB/Swiss-Prot
      A0A024R6Y5, B2RCF8, B3KS59, I3L248, Q6UX92, Q8TC95, Q9H4A9
      Related
      ENSP00000458977.1, ENST00000572888.5
      Conserved Domains (1) summary
      pfam01244
      Location:78 → 399
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    3. NM_022355.4 → NP_071750.1  dipeptidase 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_071750.1

      Status: VALIDATED

      Source sequence(s)
      AJ295149, BP299049, CB528462
      Consensus CDS
      CCDS10857.1
      UniProtKB/Swiss-Prot
      A0A024R6Y5, B2RCF8, B3KS59, I3L248, Q6UX92, Q8TC95, Q9H4A9
      Related
      ENSP00000377430.1, ENST00000393847.6
      Conserved Domains (1) summary
      pfam01244
      Location:78 → 399
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    RNA

    1. NR_136706.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA404265, AC040162, AK092884
      Related
      ENST00000575203.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67987390..68000619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023547.2 → XP_016879036.1  dipeptidase 2 isoform X14

    2. XM_024450376.2 → XP_024306144.1  dipeptidase 2 isoform X13

      Conserved Domains (1) summary
      cl00281
      Location:18 → 191
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    3. XM_011523274.4 → XP_011521576.1  dipeptidase 2 isoform X12

      Conserved Domains (1) summary
      cl00281
      Location:18 → 204
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    4. XM_011523273.4 → XP_011521575.1  dipeptidase 2 isoform X10

      See identical proteins and their annotated locations for XP_011521575.1

      Conserved Domains (1) summary
      pfam01244
      Location:1 → 254
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    5. XM_024450373.2 → XP_024306141.1  dipeptidase 2 isoform X1

      Conserved Domains (1) summary
      pfam01244
      Location:78 → 412
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    6. XM_047434462.1 → XP_047290418.1  dipeptidase 2 isoform X6

    7. XM_024450374.2 → XP_024306142.1  dipeptidase 2 isoform X1

      Conserved Domains (1) summary
      pfam01244
      Location:78 → 412
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    8. XM_047434461.1 → XP_047290417.1  dipeptidase 2 isoform X4

    9. XM_011523266.2 → XP_011521568.1  dipeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_011521568.1

      Conserved Domains (1) summary
      pfam01244
      Location:78 → 412
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    10. XM_047434459.1 → XP_047290415.1  dipeptidase 2 isoform X1

    11. XM_017023545.2 → XP_016879034.1  dipeptidase 2 isoform X10

      Conserved Domains (1) summary
      pfam01244
      Location:1 → 254
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    12. XM_047434460.1 → XP_047290416.1  dipeptidase 2 isoform X3

      UniProtKB/Swiss-Prot
      A0A024R6Y5, B2RCF8, B3KS59, I3L248, Q6UX92, Q8TC95, Q9H4A9

    13. XM_024450372.2 → XP_024306140.1  dipeptidase 2 isoform X1

      Conserved Domains (1) summary
      pfam01244
      Location:78 → 412
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    14. XM_011523271.3 → XP_011521573.1  dipeptidase 2 isoform X8

      Conserved Domains (1) summary
      pfam01244
      Location:78 → 306
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    15. XM_005256090.5 → XP_005256147.2  dipeptidase 2 isoform X5

      Conserved Domains (1) summary
      pfam01244
      Location:78 → 356
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    16. XM_011523268.3 → XP_011521570.1  dipeptidase 2 isoform X2

      Conserved Domains (1) summary
      pfam01244
      Location:78 → 404
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    17. XM_047434464.1 → XP_047290420.1  dipeptidase 2 isoform X9

    18. XM_047434463.1 → XP_047290419.1  dipeptidase 2 isoform X7

    19. XM_047434465.1 → XP_047290421.1  dipeptidase 2 isoform X11

    RNA

    1. XR_933392.4 RNA Sequence

    2. XR_243420.5 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73783178..73796408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313624.1 → XP_054169599.1  dipeptidase 2 isoform X1

    2. XM_054313638.1 → XP_054169613.1  dipeptidase 2 isoform X12

    3. XM_054313640.1 → XP_054169615.1  dipeptidase 2 isoform X14

    4. XM_054313635.1 → XP_054169610.1  dipeptidase 2 isoform X10

    5. XM_054313639.1 → XP_054169614.1  dipeptidase 2 isoform X13

    6. XM_054313631.1 → XP_054169606.1  dipeptidase 2 isoform X6

    7. XM_054313625.1 → XP_054169600.1  dipeptidase 2 isoform X1

    8. XM_054313629.1 → XP_054169604.1  dipeptidase 2 isoform X4

    9. XM_054313626.1 → XP_054169601.1  dipeptidase 2 isoform X1

    10. XM_054313623.1 → XP_054169598.1  dipeptidase 2 isoform X1

    11. XM_054313636.1 → XP_054169611.1  dipeptidase 2 isoform X10

    12. XM_054313628.1 → XP_054169603.1  dipeptidase 2 isoform X3

      UniProtKB/Swiss-Prot
      A0A024R6Y5, B2RCF8, B3KS59, I3L248, Q6UX92, Q8TC95, Q9H4A9

    13. XM_054313622.1 → XP_054169597.1  dipeptidase 2 isoform X1

    14. XM_054313633.1 → XP_054169608.1  dipeptidase 2 isoform X8

    15. XM_054313630.1 → XP_054169605.1  dipeptidase 2 isoform X5

    16. XM_054313627.1 → XP_054169602.1  dipeptidase 2 isoform X2

    17. XM_054313634.1 → XP_054169609.1  dipeptidase 2 isoform X9

    18. XM_054313632.1 → XP_054169607.1  dipeptidase 2 isoform X7

    19. XM_054313637.1 → XP_054169612.1  dipeptidase 2 isoform X11

    RNA

    1. XR_008484714.1 RNA Sequence

    2. XR_008484713.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H4A9.3 GenPept UniProtKB/Swiss-Prot:Q9H4A9

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