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    MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils [ Homo sapiens (human) ]

    Gene ID: 84437, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MSANTD4provided by HGNC
    Official Full Name
    Myb/SANT DNA binding domain containing 4 with coiled-coilsprovided by HGNC
    Primary source
    HGNC:HGNC:29383
    See related
    Ensembl:ENSG00000170903 AllianceGenome:HGNC:29383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA1826
    Summary
    Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 8.0), thyroid (RPKM 6.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MSANTD4 in Genome Data Viewer
    Location:
    11q22.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (106007899..106022287, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (106012491..106026880, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (105878626..105893014, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor AMPA type subunit 4 Neighboring gene RNA, U4 small nuclear 55, pseudogene Neighboring gene uncharacterized LOC124902743 Neighboring gene RNA, U6 small nuclear 277, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5468 Neighboring gene kelch repeat and BTB domain containing 3 Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
    2. PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. Adhikari B, et al. Nat Chem Biol, 2020 Nov. PMID 32989298, Free PMC Article
    3. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article
    4. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article
    5. From ORFeome to biology: a functional genomics pipeline. Wiemann S, et al. Genome Res, 2004 Oct. PMID 15489336, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1826

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    myb/SANT-like DNA-binding domain-containing protein 4
    Names
    Myb/SANT-like DNA-binding domain containing 4 with coiled-coils

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318747.1 → NP_001305676.1  myb/SANT-like DNA-binding domain-containing protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AB058729, AI127319, AP000813, DA758665, DA796698
      Consensus CDS
      CCDS31663.1
      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
      Conserved Domains (2) summary
      COG1196
      Location:209 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13873
      Location:8 → 86
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

    2. NM_001318748.1 → NP_001305677.1  myb/SANT-like DNA-binding domain-containing protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AB058729, AI127319, AP000813, DA448146, DA796698
      Consensus CDS
      CCDS31663.1
      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
      Conserved Domains (2) summary
      COG1196
      Location:209 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13873
      Location:8 → 86
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

    3. NM_001318749.1 → NP_001305678.1  myb/SANT-like DNA-binding domain-containing protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AI127319, AP000813, BC041118, DA529795, DA796698
      Consensus CDS
      CCDS31663.1
      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
      Conserved Domains (2) summary
      COG1196
      Location:209 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13873
      Location:8 → 86
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

    4. NM_001318750.1 → NP_001305679.1  myb/SANT-like DNA-binding domain-containing protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AI127319, AP000813, BC041118, DA796698
      Consensus CDS
      CCDS31663.1
      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
      Conserved Domains (2) summary
      COG1196
      Location:209 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13873
      Location:8 → 86
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

    5. NM_032424.3 → NP_115800.1  myb/SANT-like DNA-binding domain-containing protein 4

      See identical proteins and their annotated locations for NP_115800.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AB058729, AI127319, AP000813, DA796698
      Consensus CDS
      CCDS31663.1
      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
      Related
      ENSP00000304713.4, ENST00000301919.9
      Conserved Domains (2) summary
      COG1196
      Location:209 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13873
      Location:8 → 86
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      106007899..106022287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427709.1 → XP_047283665.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4

    2. XM_017018416.2 → XP_016873905.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
      Conserved Domains (2) summary
      COG1196
      Location:209 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13873
      Location:8 → 86
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

    3. XM_017018417.2 → XP_016873906.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
      Conserved Domains (2) summary
      COG1196
      Location:209 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13873
      Location:8 → 86
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

    4. XM_011543022.4 → XP_011541324.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011541324.1

      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
      Conserved Domains (2) summary
      COG1196
      Location:209 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13873
      Location:8 → 86
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      106012491..106026880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370187.1 → XP_054226162.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4

    2. XM_054370186.1 → XP_054226161.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4

    3. XM_054370185.1 → XP_054226160.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4

    4. XM_054370188.1 → XP_054226163.1  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q8NCY6, Q96JK1, Q96JZ3, Q9H2N4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NCY6.1 GenPept UniProtKB/Swiss-Prot:Q8NCY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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