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    XRRA1 X-ray radiation resistance associated 1 [ Homo sapiens (human) ]

    Gene ID: 143570, updated on 14-Nov-2024

    Summary

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    Official Symbol
    XRRA1provided by HGNC
    Official Full Name
    X-ray radiation resistance associated 1provided by HGNC
    Primary source
    HGNC:HGNC:18868
    See related
    Ensembl:ENSG00000166435 MIM:609788; AllianceGenome:HGNC:18868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Involved in response to X-ray. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 10.6), thyroid (RPKM 6.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See XRRA1 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (74840910..74949091, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (74770425..74878625, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74551955..74660136, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr11:74459725-74459945 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74460158-74460751 Neighboring gene RNF169 intron CAGE-defined mid-level expression enhancer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:74466374-74466995 Neighboring gene ribosomal protein S12 pseudogene 22 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3758 Neighboring gene ring finger protein 169 Neighboring gene uncharacterized LOC124902715 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:74523526-74523714 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:74554898-74556097 Neighboring gene RNA, 7SL, cytoplasmic 239, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:74593699-74594283 Neighboring gene uncharacterized LOC107984352 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:74644275-74644750 Neighboring gene ribosomal protein L31 pseudogene 46 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74659504-74660358 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74660359-74661213 Neighboring gene signal peptidase complex subunit 2 Neighboring gene RNA, U6 small nuclear 216, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5261 Neighboring gene neuraminidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Diesel exhaust particles disturb gene expression in mouse testis. Mori T, et al. Environ Toxicol, 2007 Feb. PMID 17295261
    2. Genetic architecture of asthma in African American patients. Chang X, et al. J Allergy Clin Immunol, 2023 Apr. PMID 36089080, Free PMC Article
    3. XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer. Wang W, et al. Biomed Res Int, 2017. PMID 29082250, Free PMC Article
    4. Molecular cloning, genomic characterization and over-expression of a novel gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR and macaque testis. Mesak FM, et al. BMC Genomics, 2003 Aug 9. PMID 12908878, Free PMC Article
    5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic architecture of asthma in African American patients.
      Title: Genetic architecture of asthma in African American patients.
    2. our results identify a novel link between XRRA1 and the ATM/CHK1/2 pathway and suggest that XRRA1 is involved in a DNA damage response that drives radio- and chemoresistance by regulating the ATM/CHK1/2 pathway.
      Title: XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer.
    3. Molecular cloning and gene expression patterns of XRRA1.
      Title: Molecular cloning, genomic characterization and over-expression of a novel gene, XRRA1, identified from human colorectal cancer cell HCT116Clone2_XRR and macaque testis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in response to X-ray IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    X-ray radiation resistance-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270380.3 → NP_001257309.1  X-ray radiation resistance-associated protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001257309.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple exons in the 3' coding region, compared to variant, which results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AP000560, AP001992
      Consensus CDS
      CCDS58160.1
      UniProtKB/Swiss-Prot
      Q6P2D8
      UniProtKB/TrEMBL
      Q8TEH2
      Related
      ENSP00000435838.1, ENST00000527087.5
      Conserved Domains (3) summary
      cd00116
      Location:134 → 265
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:142 → 164
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:140 → 199
      LRR_8; Leucine rich repeat

    2. NM_001270381.3 → NP_001257310.1  X-ray radiation resistance-associated protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AP000560, AP001992
      Consensus CDS
      CCDS58159.1
      UniProtKB/Swiss-Prot
      Q6P2D8
      UniProtKB/TrEMBL
      Q8TEH2
      Related
      ENSP00000319303.8, ENST00000321448.12

    3. NM_001378157.1 → NP_001365086.1  X-ray radiation resistance-associated protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AP000560, AP001992
      Consensus CDS
      CCDS91535.1
      UniProtKB/TrEMBL
      A0A804HIK0, A0A994J5L1
      Related
      ENSP00000507107.1, ENST00000684022.1
      Conserved Domains (2) summary
      COG4886
      Location:116 → 320
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:150 → 172
      LRR_RI; leucine-rich repeat [structural motif]

    4. NM_001378158.1 → NP_001365087.1  X-ray radiation resistance-associated protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992
      UniProtKB/TrEMBL
      A0A994J5L1
      Conserved Domains (2) summary
      COG4886
      Location:116 → 320
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:150 → 172
      LRR_RI; leucine-rich repeat [structural motif]

    5. NM_001378159.1 → NP_001365088.1  X-ray radiation resistance-associated protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992
      Conserved Domains (2) summary
      COG4886
      Location:116 → 320
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:150 → 172
      LRR_RI; leucine-rich repeat [structural motif]

    6. NM_001378160.1 → NP_001365089.1  X-ray radiation resistance-associated protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992
      Conserved Domains (2) summary
      COG4886
      Location:116 → 320
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:150 → 172
      LRR_RI; leucine-rich repeat [structural motif]

    7. NM_001378161.1 → NP_001365090.1  X-ray radiation resistance-associated protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992

    8. NM_001378162.1 → NP_001365091.1  X-ray radiation resistance-associated protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992
      UniProtKB/TrEMBL
      Q8TEH2

    9. NM_001378163.1 → NP_001365092.1  X-ray radiation resistance-associated protein 1 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variant 11, encodes isoform 10.
      Source sequence(s)
      AP000560, AP001992

    10. NM_001378164.1 → NP_001365093.1  X-ray radiation resistance-associated protein 1 isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variant 10, encodes isoform 10.
      Source sequence(s)
      AP000560, AP001992

    11. NM_001378165.1 → NP_001365094.1  X-ray radiation resistance-associated protein 1 isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform 11.
      Source sequence(s)
      AP000560, AP001992
      UniProtKB/TrEMBL
      Q8TEH2

    12. NM_001378166.1 → NP_001365095.1  X-ray radiation resistance-associated protein 1 isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform 11.
      Source sequence(s)
      AP000560, AP001992
      UniProtKB/TrEMBL
      Q8TEH2

    13. NM_001378167.1 → NP_001365096.1  X-ray radiation resistance-associated protein 1 isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform 11.
      Source sequence(s)
      AP000560, AP001992
      UniProtKB/TrEMBL
      Q8TEH2

    14. NM_001378168.1 → NP_001365097.1  X-ray radiation resistance-associated protein 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992

    15. NM_001378169.1 → NP_001365098.1  X-ray radiation resistance-associated protein 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992
      UniProtKB/TrEMBL
      Q8TEH2

    16. NM_001378170.1 → NP_001365099.1  X-ray radiation resistance-associated protein 1 isoform 14

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variant 18, encodes isoform 14.
      Source sequence(s)
      AP000560, AP001992

    17. NM_001378171.1 → NP_001365100.1  X-ray radiation resistance-associated protein 1 isoform 14

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variant 17, encodes isoform 14.
      Source sequence(s)
      AP000560, AP001992

    18. NM_001378172.1 → NP_001365101.1  X-ray radiation resistance-associated protein 1 isoform 15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variant 20, encodes isoform 15.
      Source sequence(s)
      AP000560, AP001992

    19. NM_001378173.1 → NP_001365102.1  X-ray radiation resistance-associated protein 1 isoform 15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variant 19, encodes isoform 15.
      Source sequence(s)
      AP000560, AP001992

    20. NM_001378174.1 → NP_001365103.1  X-ray radiation resistance-associated protein 1 isoform 16

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21), as well as variants 22 and 23, encodes isoform 16.
      Source sequence(s)
      AP000560, AP001992

    21. NM_001378175.1 → NP_001365104.1  X-ray radiation resistance-associated protein 1 isoform 16

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22), as well as variants 21 and 23, encodes isoform 16.
      Source sequence(s)
      AP000560, AP001992

    22. NM_001378176.1 → NP_001365105.1  X-ray radiation resistance-associated protein 1 isoform 16

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23), as well as variants 21 and 22, encodes isoform 16.
      Source sequence(s)
      AP000560, AP001992

    23. NM_182969.4 → NP_892014.1  X-ray radiation resistance-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_892014.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AP000560, AP001992
      Consensus CDS
      CCDS44680.1
      UniProtKB/Swiss-Prot
      B5MD90, J3KNJ1, Q6P2D8, Q7RTT7, Q7Z463, Q7Z4U0
      UniProtKB/TrEMBL
      A0A994J5L1
      Related
      ENSP00000339918.6, ENST00000340360.10
      Conserved Domains (3) summary
      cd00116
      Location:134 → 265
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:142 → 164
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:140 → 199
      LRR_8; Leucine rich repeat

    RNA

    1. NR_165434.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992

    2. NR_165435.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992

    3. NR_165436.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992
      Related
      ENST00000531849.5

    4. NR_165437.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992

    5. NR_165438.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992

    6. NR_165439.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000560, AP001992

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      74840910..74949091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426407.1 → XP_047282363.1  X-ray radiation resistance-associated protein 1 isoform X28

    2. XM_047426401.1 → XP_047282357.1  X-ray radiation resistance-associated protein 1 isoform X22

    3. XM_047426404.1 → XP_047282360.1  X-ray radiation resistance-associated protein 1 isoform X25

    4. XM_047426392.1 → XP_047282348.1  X-ray radiation resistance-associated protein 1 isoform X13

    5. XM_047426396.1 → XP_047282352.1  X-ray radiation resistance-associated protein 1 isoform X25

    6. XM_011544765.2 → XP_011543067.1  X-ray radiation resistance-associated protein 1 isoform X13

      See identical proteins and their annotated locations for XP_011543067.1

    7. XM_047426406.1 → XP_047282362.1  X-ray radiation resistance-associated protein 1 isoform X28

    8. XM_047426399.1 → XP_047282355.1  X-ray radiation resistance-associated protein 1 isoform X22

    9. XM_047426408.1 → XP_047282364.1  X-ray radiation resistance-associated protein 1 isoform X29

    10. XM_047426402.1 → XP_047282358.1  X-ray radiation resistance-associated protein 1 isoform X25

    11. XM_047426405.1 → XP_047282361.1  X-ray radiation resistance-associated protein 1 isoform X26

    12. XM_047426394.1 → XP_047282350.1  X-ray radiation resistance-associated protein 1 isoform X23

    13. XM_047426388.1 → XP_047282344.1  X-ray radiation resistance-associated protein 1 isoform X13

    14. XM_047426393.1 → XP_047282349.1  X-ray radiation resistance-associated protein 1 isoform X22

    15. XM_047426395.1 → XP_047282351.1  X-ray radiation resistance-associated protein 1 isoform X25

    16. XM_047426400.1 → XP_047282356.1  X-ray radiation resistance-associated protein 1 isoform X26

    17. XM_047426391.1 → XP_047282347.1  X-ray radiation resistance-associated protein 1 isoform X21

    18. XM_017017228.3 → XP_016872717.1  X-ray radiation resistance-associated protein 1 isoform X24

    19. XM_005273770.3 → XP_005273827.1  X-ray radiation resistance-associated protein 1 isoform X13

      See identical proteins and their annotated locations for XP_005273827.1

    20. XM_047426397.1 → XP_047282353.1  X-ray radiation resistance-associated protein 1 isoform X23

    21. XM_047426387.1 → XP_047282343.1  X-ray radiation resistance-associated protein 1 isoform X17

    22. XM_011544761.2 → XP_011543063.1  X-ray radiation resistance-associated protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A994J5L1
      Conserved Domains (2) summary
      COG4886
      Location:95 → 196
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:95 → 115
      LRR_1; leucine-rich repeat [structural motif]

    23. XM_011544759.2 → XP_011543061.1  X-ray radiation resistance-associated protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A994J5L1
      Conserved Domains (3) summary
      cd00116
      Location:105 → 208
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:110 → 131
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:130 → 208
      LRR_8; Leucine rich repeat

    24. XM_047426382.1 → XP_047282338.1  X-ray radiation resistance-associated protein 1 isoform X9

    25. XM_047426384.1 → XP_047282340.1  X-ray radiation resistance-associated protein 1 isoform X12

    26. XM_047426390.1 → XP_047282346.1  X-ray radiation resistance-associated protein 1 isoform X20

    27. XM_047426383.1 → XP_047282339.1  X-ray radiation resistance-associated protein 1 isoform X11

    28. XM_011544758.2 → XP_011543060.1  X-ray radiation resistance-associated protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A994J5L1
      Conserved Domains (3) summary
      cd00116
      Location:119 → 216
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:117 → 139
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:138 → 216
      LRR_8; Leucine rich repeat

    29. XM_017017224.3 → XP_016872713.1  X-ray radiation resistance-associated protein 1 isoform X18

      Conserved Domains (2) summary
      COG4886
      Location:116 → 320
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:150 → 172
      LRR_RI; leucine-rich repeat [structural motif]

    30. XM_011544762.2 → XP_011543064.1  X-ray radiation resistance-associated protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A994J5L1
      Conserved Domains (3) summary
      cd00116
      Location:142 → 273
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:150 → 172
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:148 → 207
      LRR_8; Leucine rich repeat

    31. XM_047426386.1 → XP_047282342.1  X-ray radiation resistance-associated protein 1 isoform X16

    32. XM_011544757.2 → XP_011543059.1  X-ray radiation resistance-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A994J5L1
      Conserved Domains (3) summary
      cd00116
      Location:142 → 273
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:150 → 172
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:148 → 207
      LRR_8; Leucine rich repeat

    33. XM_017017222.3 → XP_016872711.1  X-ray radiation resistance-associated protein 1 isoform X14

    34. XM_011544756.2 → XP_011543058.1  X-ray radiation resistance-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A994J5L1
      Conserved Domains (3) summary
      cd00116
      Location:142 → 273
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:150 → 172
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:148 → 207
      LRR_8; Leucine rich repeat

    35. XM_017017221.2 → XP_016872710.1  X-ray radiation resistance-associated protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A994J5L1

    36. XM_011544755.2 → XP_011543057.1  X-ray radiation resistance-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A994J5L1
      Conserved Domains (2) summary
      COG4886
      Location:116 → 320
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:150 → 172
      LRR_RI; leucine-rich repeat [structural motif]

    37. XM_011544763.3 → XP_011543065.1  X-ray radiation resistance-associated protein 1 isoform X10

      Conserved Domains (3) summary
      cd00116
      Location:142 → 273
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:150 → 172
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:148 → 207
      LRR_8; Leucine rich repeat

    38. XM_047426403.1 → XP_047282359.1  X-ray radiation resistance-associated protein 1 isoform X27

    39. XM_047426389.1 → XP_047282345.1  X-ray radiation resistance-associated protein 1 isoform X19

    40. XM_047426385.1 → XP_047282341.1  X-ray radiation resistance-associated protein 1 isoform X15

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      74770425..74878625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367745.1 → XP_054223720.1  X-ray radiation resistance-associated protein 1 isoform X28

    2. XM_054367739.1 → XP_054223714.1  X-ray radiation resistance-associated protein 1 isoform X22

    3. XM_054367742.1 → XP_054223717.1  X-ray radiation resistance-associated protein 1 isoform X25

    4. XM_054367730.1 → XP_054223705.1  X-ray radiation resistance-associated protein 1 isoform X13

    5. XM_054367735.1 → XP_054223710.1  X-ray radiation resistance-associated protein 1 isoform X25

    6. XM_054367721.1 → XP_054223696.1  X-ray radiation resistance-associated protein 1 isoform X13

    7. XM_054367744.1 → XP_054223719.1  X-ray radiation resistance-associated protein 1 isoform X28

    8. XM_054367737.1 → XP_054223712.1  X-ray radiation resistance-associated protein 1 isoform X22

    9. XM_054367746.1 → XP_054223721.1  X-ray radiation resistance-associated protein 1 isoform X29

    10. XM_054367740.1 → XP_054223715.1  X-ray radiation resistance-associated protein 1 isoform X25

    11. XM_054367743.1 → XP_054223718.1  X-ray radiation resistance-associated protein 1 isoform X26

    12. XM_054367732.1 → XP_054223707.1  X-ray radiation resistance-associated protein 1 isoform X23

    13. XM_054367726.1 → XP_054223701.1  X-ray radiation resistance-associated protein 1 isoform X13

    14. XM_054367731.1 → XP_054223706.1  X-ray radiation resistance-associated protein 1 isoform X22

    15. XM_054367734.1 → XP_054223709.1  X-ray radiation resistance-associated protein 1 isoform X25

    16. XM_054367738.1 → XP_054223713.1  X-ray radiation resistance-associated protein 1 isoform X26

    17. XM_054367729.1 → XP_054223704.1  X-ray radiation resistance-associated protein 1 isoform X21

    18. XM_054367733.1 → XP_054223708.1  X-ray radiation resistance-associated protein 1 isoform X24

    19. XM_054367719.1 → XP_054223694.1  X-ray radiation resistance-associated protein 1 isoform X13

    20. XM_054367736.1 → XP_054223711.1  X-ray radiation resistance-associated protein 1 isoform X23

    21. XM_054367724.1 → XP_054223699.1  X-ray radiation resistance-associated protein 1 isoform X17

    22. XM_054367713.1 → XP_054223688.1  X-ray radiation resistance-associated protein 1 isoform X7

    23. XM_054367711.1 → XP_054223686.1  X-ray radiation resistance-associated protein 1 isoform X5

    24. XM_054367715.1 → XP_054223690.1  X-ray radiation resistance-associated protein 1 isoform X9

    25. XM_054367718.1 → XP_054223693.1  X-ray radiation resistance-associated protein 1 isoform X12

    26. XM_054367728.1 → XP_054223703.1  X-ray radiation resistance-associated protein 1 isoform X20

    27. XM_054367717.1 → XP_054223692.1  X-ray radiation resistance-associated protein 1 isoform X11

    28. XM_054367709.1 → XP_054223684.1  X-ray radiation resistance-associated protein 1 isoform X4

    29. XM_054367725.1 → XP_054223700.1  X-ray radiation resistance-associated protein 1 isoform X18

    30. XM_054367714.1 → XP_054223689.1  X-ray radiation resistance-associated protein 1 isoform X8

    31. XM_054367723.1 → XP_054223698.1  X-ray radiation resistance-associated protein 1 isoform X16

    32. XM_054367710.1 → XP_054223685.1  X-ray radiation resistance-associated protein 1 isoform X3

    33. XM_054367720.1 → XP_054223695.1  X-ray radiation resistance-associated protein 1 isoform X14

    34. XM_054367708.1 → XP_054223683.1  X-ray radiation resistance-associated protein 1 isoform X2

    35. XM_054367712.1 → XP_054223687.1  X-ray radiation resistance-associated protein 1 isoform X6

    36. XM_054367707.1 → XP_054223682.1  X-ray radiation resistance-associated protein 1 isoform X1

    37. XM_054367716.1 → XP_054223691.1  X-ray radiation resistance-associated protein 1 isoform X10

    38. XM_054367741.1 → XP_054223716.1  X-ray radiation resistance-associated protein 1 isoform X27

    39. XM_054367727.1 → XP_054223702.1  X-ray radiation resistance-associated protein 1 isoform X19

    40. XM_054367722.1 → XP_054223697.1  X-ray radiation resistance-associated protein 1 isoform X15

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P2D8.2 GenPept UniProtKB/Swiss-Prot:Q6P2D8

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