U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    RHBDD1 rhomboid domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 84236, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RHBDD1provided by HGNC
    Official Full Name
    rhomboid domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:23081
    See related
    Ensembl:ENSG00000144468 MIM:617515; AllianceGenome:HGNC:23081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RRP4; RHBDL4
    Summary
    Enables serine-type endopeptidase activity. Involved in several processes, including cellular response to unfolded protein; membrane protein proteolysis; and positive regulation of protein catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 3.8), thyroid (RPKM 3.6) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RHBDD1 in Genome Data Viewer
    Location:
    2q36.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (226800159..226999210)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (227283017..227481905)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (227664875..227863926)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak4064 silencer Neighboring gene MPRA-validated peak4065 silencer Neighboring gene microRNA 5702 Neighboring gene Sharpr-MPRA regulatory region 3334 Neighboring gene MPRA-validated peak4066 silencer Neighboring gene Sharpr-MPRA regulatory region 11623 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12389 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:227661675-227662624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12393 Neighboring gene insulin receptor substrate 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:227677874-227678445 Neighboring gene Sharpr-MPRA regulatory region 3963 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12395 Neighboring gene MPRA-validated peak4067 silencer Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17196 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:227859794-227860993 Neighboring gene collagen type IV alpha 4 chain Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:227929821-227930408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:228028248-228029149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12397 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:228050272-228050810 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:228055439-228056638 Neighboring gene collagen type IV alpha 3 chain Neighboring gene MFF divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:228185522-228186050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12398 Neighboring gene stress induced phosphoprotein 1 pseudogene 2 Neighboring gene mitochondrial fission factor

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Eta-secretase-like processing of the amyloid precursor protein (APP) by the rhomboid protease RHBDL4. Penalva YCM, et al. J Biol Chem, 2024 Aug. PMID 38992438, Free PMC Article
    2. Membrane cholesterol as regulator of human rhomboid protease RHBDL4. Paschkowsky S, et al. J Biol Chem, 2018 Oct 5. PMID 30143535, Free PMC Article
    3. Silibinin suppresses epithelial-mesenchymal transition in human non-small cell lung cancer cells by restraining RHBDD1. Xu S, et al. Cell Mol Biol Lett, 2020. PMID 32528541, Free PMC Article
    4. Lentivirus-mediated silencing of rhomboid domain containing 1 suppresses tumor growth and induces apoptosis in hepatoma HepG2 cells. Liu XN, et al. Asian Pac J Cancer Prev, 2013. PMID 23534782
    5. RHBDD1 promotes proliferation, migration, invasion and EMT in renal cell carcinoma via the EGFR/AKT signaling pathway. Li M, et al. Mol Med Rep, 2021 Dec. PMID 34581421, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Eta-secretase-like processing of the amyloid precursor protein (APP) by the rhomboid protease RHBDL4.
      Title: Eta-secretase-like processing of the amyloid precursor protein (APP) by the rhomboid protease RHBDL4.
    2. CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer.
      Title: CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer.
    3. RHBDD1 Promotes the Growth and Stemness Characteristics of Gastric Cancer Cells by Activating Wnt/beta-catenin Signaling Pathway.
      Title: RHBDD1 Promotes the Growth and Stemness Characteristics of Gastric Cancer Cells by Activating Wnt/β-catenin Signaling Pathway.
    4. RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling.
      Title: RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling.
    5. MiR-5195-3p functions as a tumor suppressor by targeting RHBDD1 in ovarian cancer.
      Title: MiR-5195-3p functions as a tumor suppressor by targeting RHBDD1 in ovarian cancer.
    6. Putative Protein Interactome of the Rhomboid Protease RHBDL4.
      Title: Putative Protein Interactome of the Rhomboid Protease RHBDL4.
    7. Prognostic and Immunological Significance of Rhomboid Domain Containing Protein 1 in Multiple Primary Cancers.
      Title: Prognostic and Immunological Significance of Rhomboid Domain Containing Protein 1 in Multiple Primary Cancers.
    8. Suppression of rhomboid domain-containing 1 produces anticancer effects in pancreatic adenocarcinoma through affection of the AKT/GSK-3beta/beta-catenin pathway.
      Title: Suppression of rhomboid domain-containing 1 produces anticancer effects in pancreatic adenocarcinoma through affection of the AKT/GSK-3β/β-catenin pathway.
    9. Rhomboid domain containing 1 promotes the growth of non-small cell lung cancer through the activation of EGFR and regulation of the BIK-mediated apoptosis.
      Title: Rhomboid domain containing 1 promotes the growth of non-small cell lung cancer through the activation of EGFR and regulation of the BIK-mediated apoptosis.
    10. RHBDD1 promotes proliferation, migration, invasion and EMT in renal cell carcinoma via the EGFR/AKT signaling pathway.
      Title: RHBDD1 promotes proliferation, migration, invasion and EMT in renal cell carcinoma via the EGFR/AKT signaling pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Framingham Heart Study genome-wide association: results for pulmonary function measures.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ45341, FLJ46780, MGC117258, DKFZp547E052

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to unfolded protein IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to unfolded protein ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane protein intracellular domain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane protein proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in membrane protein proteolysis involved in retrograde protein transport, ER to cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in regulation of male germ cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatid differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum quality control compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    rhomboid-related protein 4
    Names
    rhomboid domain-containing protein 1
    rhomboid like 4
    rhomboid-like protein 4
    NP_001161080.1
    NP_001335998.1
    NP_001336000.1
    NP_001336001.1
    NP_115652.2
    XP_016860572.1
    XP_016860573.1
    XP_016860574.1
    XP_016860575.1
    XP_016860576.1
    XP_016860577.1
    XP_016860579.1
    XP_016860581.1
    XP_016860583.1
    XP_047301937.1
    XP_047301938.1
    XP_047301939.1
    XP_047301940.1
    XP_047301941.1
    XP_047301942.1
    XP_047301943.1
    XP_047301944.1
    XP_047301945.1
    XP_047301947.1
    XP_047301948.1
    XP_047301949.1
    XP_047301950.1
    XP_047301951.1
    XP_047301953.1
    XP_047301954.1
    XP_047301955.1
    XP_047301956.1
    XP_047301957.1
    XP_047301958.1
    XP_047301960.1
    XP_047301961.1
    XP_047301962.1
    XP_047301963.1
    XP_054200121.1
    XP_054200122.1
    XP_054200123.1
    XP_054200124.1
    XP_054200125.1
    XP_054200126.1
    XP_054200127.1
    XP_054200128.1
    XP_054200129.1
    XP_054200130.1
    XP_054200131.1
    XP_054200132.1
    XP_054200133.1
    XP_054200134.1
    XP_054200135.1
    XP_054200136.1
    XP_054200137.1
    XP_054200138.1
    XP_054200139.1
    XP_054200140.1
    XP_054200141.1
    XP_054200142.1
    XP_054200143.1
    XP_054200144.1
    XP_054200145.1
    XP_054200146.1
    XP_054200147.1
    XP_054200148.1
    XP_054200149.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167608.3 → NP_001161080.1  rhomboid-related protein 4

      See identical proteins and their annotated locations for NP_001161080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC010735, AC073149, CA434330, DB024396
      Consensus CDS
      CCDS2464.1
      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Related
      ENSP00000375914.2, ENST00000392062.7
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    2. NM_001349069.2 → NP_001335998.1  rhomboid-related protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC010735, AC073149, CA434330
      Consensus CDS
      CCDS2464.1
      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    3. NM_001349071.2 → NP_001336000.1  rhomboid-related protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC010735, AC073149, CA434330
      Consensus CDS
      CCDS2464.1
      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    4. NM_001349072.2 → NP_001336001.1  rhomboid-related protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC010735, AC073149, CA434330
      Consensus CDS
      CCDS2464.1
      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    5. NM_032276.5 → NP_115652.2  rhomboid-related protein 4

      See identical proteins and their annotated locations for NP_115652.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variants 2-5 encode the same protein.
      Source sequence(s)
      AC010735, AC073149, AK074258, CA434330
      Consensus CDS
      CCDS2464.1
      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Related
      ENSP00000344779.3, ENST00000341329.7
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      226800159..226999210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445998.1 → XP_047301954.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    2. XM_047445995.1 → XP_047301951.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    3. XM_017005083.2 → XP_016860572.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    4. XM_017005088.2 → XP_016860577.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    5. XM_017005085.3 → XP_016860574.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    6. XM_017005087.3 → XP_016860576.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    7. XM_017005084.3 → XP_016860573.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    8. XM_017005090.3 → XP_016860579.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    9. XM_017005086.3 → XP_016860575.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    10. XM_017005092.3 → XP_016860581.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057
      Conserved Domains (1) summary
      cl21536
      Location:64 → 206
      Rhomboid; Rhomboid family

    11. XM_047445999.1 → XP_047301955.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    12. XM_047445997.1 → XP_047301953.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    13. XM_047445981.1 → XP_047301937.1  rhomboid-related protein 4 isoform X1

    14. XM_047445993.1 → XP_047301949.1  rhomboid-related protein 4 isoform X1

    15. XM_047445984.1 → XP_047301940.1  rhomboid-related protein 4 isoform X1

    16. XM_047445987.1 → XP_047301943.1  rhomboid-related protein 4 isoform X1

    17. XM_047445982.1 → XP_047301938.1  rhomboid-related protein 4 isoform X1

    18. XM_047445985.1 → XP_047301941.1  rhomboid-related protein 4 isoform X1

    19. XM_047445989.1 → XP_047301945.1  rhomboid-related protein 4 isoform X1

    20. XM_047445991.1 → XP_047301947.1  rhomboid-related protein 4 isoform X1

    21. XM_047445992.1 → XP_047301948.1  rhomboid-related protein 4 isoform X1

    22. XM_047445983.1 → XP_047301939.1  rhomboid-related protein 4 isoform X1

    23. XM_047445988.1 → XP_047301944.1  rhomboid-related protein 4 isoform X1

    24. XM_047445994.1 → XP_047301950.1  rhomboid-related protein 4 isoform X1

    25. XM_047445986.1 → XP_047301942.1  rhomboid-related protein 4 isoform X1

    26. XM_047446002.1 → XP_047301958.1  rhomboid-related protein 4 isoform X3

    27. XM_047446005.1 → XP_047301961.1  rhomboid-related protein 4 isoform X4

    28. XM_047446001.1 → XP_047301957.1  rhomboid-related protein 4 isoform X3

    29. XM_017005094.2 → XP_016860583.1  rhomboid-related protein 4 isoform X3

    30. XM_047446000.1 → XP_047301956.1  rhomboid-related protein 4 isoform X3

    31. XM_047446004.1 → XP_047301960.1  rhomboid-related protein 4 isoform X3

    32. XM_047446007.1 → XP_047301963.1  rhomboid-related protein 4 isoform X5

    33. XM_047446006.1 → XP_047301962.1  rhomboid-related protein 4 isoform X5

    RNA

    1. XR_007082541.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      227283017..227481905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344167.1 → XP_054200142.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    2. XM_054344159.1 → XP_054200134.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    3. XM_054344148.1 → XP_054200123.1  rhomboid-related protein 4 isoform X1

    4. XM_054344163.1 → XP_054200138.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    5. XM_054344147.1 → XP_054200122.1  rhomboid-related protein 4 isoform X1

    6. XM_054344152.1 → XP_054200127.1  rhomboid-related protein 4 isoform X1

    7. XM_054344157.1 → XP_054200132.1  rhomboid-related protein 4 isoform X1

    8. XM_054344150.1 → XP_054200125.1  rhomboid-related protein 4 isoform X1

    9. XM_054344168.1 → XP_054200143.1  rhomboid-related protein 4 isoform X3

    10. XM_054344171.1 → XP_054200146.1  rhomboid-related protein 4 isoform X3

    11. XM_054344174.1 → XP_054200149.1  rhomboid-related protein 4 isoform X5

    12. XM_054344165.1 → XP_054200140.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    13. XM_054344153.1 → XP_054200128.1  rhomboid-related protein 4 isoform X1

    14. XM_054344164.1 → XP_054200139.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    15. XM_054344162.1 → XP_054200137.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    16. XM_054344158.1 → XP_054200133.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    17. XM_054344161.1 → XP_054200136.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    18. XM_054344151.1 → XP_054200126.1  rhomboid-related protein 4 isoform X1

    19. XM_054344146.1 → XP_054200121.1  rhomboid-related protein 4 isoform X1

    20. XM_054344170.1 → XP_054200145.1  rhomboid-related protein 4 isoform X3

    21. XM_054344173.1 → XP_054200148.1  rhomboid-related protein 4 isoform X4

    22. XM_054344172.1 → XP_054200147.1  rhomboid-related protein 4 isoform X3

    23. XM_054344149.1 → XP_054200124.1  rhomboid-related protein 4 isoform X1

    24. XM_054344155.1 → XP_054200130.1  rhomboid-related protein 4 isoform X1

    25. XM_054344169.1 → XP_054200144.1  rhomboid-related protein 4 isoform X3

    26. XM_054344160.1 → XP_054200135.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    27. XM_054344154.1 → XP_054200129.1  rhomboid-related protein 4 isoform X1

    28. XM_054344166.1 → XP_054200141.1  rhomboid-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q495B9, Q53S43, Q5EBM8, Q6P5V8, Q8IV60, Q8TEB9, Q9H057

    29. XM_054344156.1 → XP_054200131.1  rhomboid-related protein 4 isoform X1

    RNA

    1. XR_008486545.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TEB9.1 GenPept UniProtKB/Swiss-Prot:Q8TEB9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools