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    AMIGO2 adhesion molecule with Ig like domain 2 [ Homo sapiens (human) ]

    Gene ID: 347902, updated on 2-Nov-2024

    Summary

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    Official Symbol
    AMIGO2provided by HGNC
    Official Full Name
    adhesion molecule with Ig like domain 2provided by HGNC
    Primary source
    HGNC:HGNC:24073
    See related
    Ensembl:ENSG00000139211 MIM:615690; AllianceGenome:HGNC:24073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALI1; DEGA; AMIGO-2
    Summary
    Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and negative regulation of programmed cell death. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in nucleus and plasma membrane. Predicted to be active in membrane. Biomarker of gastric adenocarcinoma. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in gall bladder (RPKM 9.4), urinary bladder (RPKM 8.8) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See AMIGO2 in Genome Data Viewer
    Location:
    12q13.11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (47075707..47079959, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (47036477..47040734, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (47469490..47473742, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902925 Neighboring gene uncharacterized LOC107984466 Neighboring gene PC-esterase domain containing 1B Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28818 Neighboring gene IFITM3P pseudogene 6 Neighboring gene microRNA 4698

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. AMIGO2 is a pivotal therapeutic target related to M2 polarization of macrophages in pancreatic ductal adenocarcinoma. Chen S, et al. Aging (Albany NY), 2024 Jan 5. PMID 38189855, Free PMC Article
    2. Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene. Fontanals-Cirera B, et al. Mol Cell, 2017 Nov 16. PMID 29149598, Free PMC Article
    3. AMIGO2 is involved in the spread of peritoneal metastasis in serous ovarian cancer via promoting adhesion to the peritoneal mesothelial cells. Iida Y, et al. Int J Clin Oncol, 2024 Sep. PMID 38811439
    4. AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer. Nakamura S, et al. Anticancer Res, 2020 Dec. PMID 33288564
    5. In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation. Liu Y, et al. Cancer Lett, 2021 Apr 10. PMID 33524500, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AMIGO2 is involved in the spread of peritoneal metastasis in serous ovarian cancer via promoting adhesion to the peritoneal mesothelial cells.
      Title: AMIGO2 is involved in the spread of peritoneal metastasis in serous ovarian cancer via promoting adhesion to the peritoneal mesothelial cells.
    2. AMIGO2 is a pivotal therapeutic target related to M2 polarization of macrophages in pancreatic ductal adenocarcinoma.
      Title: AMIGO2 is a pivotal therapeutic target related to M2 polarization of macrophages in pancreatic ductal adenocarcinoma.
    3. AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME-conferred pyroptosis in non-small cell lung cancer.
      Title: AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME-conferred pyroptosis in non-small cell lung cancer.
    4. Liver Metastasis Formation Is Defined by AMIGO2 Expression via Adhesion to Hepatic Endothelial Cells in Human Gastric and Colorectal Cancer Cells.
      Title: Liver Metastasis Formation Is Defined by AMIGO2 Expression via Adhesion to Hepatic Endothelial Cells in Human Gastric and Colorectal Cancer Cells.
    5. The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients.
      Title: The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients.
    6. AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells.
      Title: AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells.
    7. In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation.
      Title: In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation.
    8. AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer.
      Title: AMIGO2 Expression as a Potential Prognostic Biomarker for Gastric Cancer.
    9. Amigo2, which is a member of the Amigo family that shows high species conservation, may be involved in determining liver metastasis by preferential adhesion of the tumour cells to liver endothelial cells.
      Title: Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases.
    10. this study uncovers mechanisms underlying the therapeutic effects of BETi in melanoma and reveals the AMIGO2-PTK7 axis as a targetable pathway for metastatic melanoma.
      Title: Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of programmed cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    amphoterin-induced protein 2
    Names
    alivin 1
    amphoterin induced gene 2
    differentially expressed in gastric adenocarcinoma
    differentially expressed in gastric adenocarcinomas
    transmembrane protein AMIGO2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143668.1 → NP_001137140.1  amphoterin-induced protein 2 precursor

      See identical proteins and their annotated locations for NP_001137140.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) includes an alternate exon in the 5' UTR. The same protein is encoded by transcript variants 1-3.
      Source sequence(s)
      AB079074, AC004010, BC047595, BC095477
      Consensus CDS
      CCDS8751.1
      UniProtKB/Swiss-Prot
      Q4VBP6, Q7Z4A0, Q86SJ2, Q96CN8
      UniProtKB/TrEMBL
      B3KRK1
      Related
      ENSP00000406020.1, ENST00000429635.1
      Conserved Domains (5) summary
      smart00410
      Location:298 → 380
      IG_like; Immunoglobulin like
      COG4886
      Location:54 → 240
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:51 → 72
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:94 → 175
      LRR_8; Leucine rich repeat
      cl15307
      Location:228 → 283
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    2. NM_001370299.1 → NP_001357228.1  amphoterin-induced protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC004010
      Consensus CDS
      CCDS8751.1
      UniProtKB/Swiss-Prot
      Q4VBP6, Q7Z4A0, Q86SJ2, Q96CN8
      UniProtKB/TrEMBL
      B3KRK1
      Related
      ENSP00000449034.1, ENST00000550413.2
      Conserved Domains (5) summary
      smart00410
      Location:298 → 380
      IG_like; Immunoglobulin like
      COG4886
      Location:54 → 240
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:51 → 72
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:94 → 175
      LRR_8; Leucine rich repeat
      cl15307
      Location:228 → 283
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    3. NM_181847.4 → NP_862830.1  amphoterin-induced protein 2 precursor

      See identical proteins and their annotated locations for NP_862830.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) omits an alternate exon from the 5' UTR. The same protein is encoded by transcript variants 1-3.
      Source sequence(s)
      AB079074, AC004010, AY454159, BC095477, CN397638
      Consensus CDS
      CCDS8751.1
      UniProtKB/Swiss-Prot
      Q4VBP6, Q7Z4A0, Q86SJ2, Q96CN8
      UniProtKB/TrEMBL
      B3KRK1
      Related
      ENSP00000266581.4, ENST00000266581.4
      Conserved Domains (5) summary
      smart00410
      Location:298 → 380
      IG_like; Immunoglobulin like
      COG4886
      Location:54 → 240
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:51 → 72
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:94 → 175
      LRR_8; Leucine rich repeat
      cl15307
      Location:228 → 283
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      47075707..47079959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428785.1 → XP_047284741.1  amphoterin-induced protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q4VBP6, Q7Z4A0, Q86SJ2, Q96CN8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      47036477..47040734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86SJ2.1 GenPept UniProtKB/Swiss-Prot:Q86SJ2

    Gene LinkOut

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