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    PRAP1 proline rich acidic protein 1 [ Homo sapiens (human) ]

    Gene ID: 118471, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PRAP1provided by HGNC
    Official Full Name
    proline rich acidic protein 1provided by HGNC
    Primary source
    HGNC:HGNC:23304
    See related
    Ensembl:ENSG00000165828 MIM:609776; AllianceGenome:HGNC:23304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UPA; PRO1195
    Summary
    Predicted to enable triglyceride binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; deactivation of mitotic spindle assembly checkpoint; and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in small intestine (RPKM 388.5), duodenum (RPKM 348.9) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRAP1 in Genome Data Viewer
    Location:
    10q26.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133347373..133352683)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134302524..134307799)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135160877..135166187)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ZNF511-PRAP1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4246 Neighboring gene calcyon neuron specific vesicular protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135148655-135149330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160243-135160902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160903-135161562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135161563-135162222 Neighboring gene BANF1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135169540-135170274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2976 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:135172784-135172946 Neighboring gene fucose mutarotase Neighboring gene enoyl-CoA hydratase, short chain 1 Neighboring gene microRNA 3944

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The proline-rich acidic protein is epigenetically regulated and inhibits growth of cancer cell lines. Zhang J, et al. Cancer Res, 2003 Oct 15. PMID 14583459
    2. PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage. Huang BH, et al. Cell Death Dis, 2012 Dec 13. PMID 23235459, Free PMC Article
    3. A novel complementary deoxyribonucleic acid is abundantly and specifically expressed in the uterus during pregnancy. Kasik J, et al. Am J Obstet Gynecol, 1997 Feb. PMID 9065197
    4. Uterine luminal epithelium-specific proline-rich acidic protein 1 (PRAP1) as a marker for successful embryo implantation. Diao H, et al. Fertil Steril, 2010 Dec. PMID 20674898
    5. Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma. Sze KM, et al. J Pathol, 2014 May. PMID 24374861

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis.
      Title: Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis.
    2. ATF3 and PRAP1 play important roles in cisplatin-induced DNA damage repair process.
      Title: ATF3 and PRAP1 play important roles in cisplatin-induced damages in microvascular endothelial cells.
    3. PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in hepatocellular carcinoma.
      Title: Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma.
    4. Induction of PRAP1 expression by p53 in response to DNA-damaging agents contributes to cancer cell survival.
      Title: PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough ZNF511-PRAP1

    Readthrough gene: ZNF511-PRAP1, Included gene: ZNF511

    Homology

    Clone Names

    • MGC126792

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables triglyceride binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to X-ray ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in deactivation of mitotic spindle assembly checkpoint IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of intestinal lipid absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of phospholipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of triglyceride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proline-rich acidic protein 1
    Names
    epididymis secretory sperm binding protein
    epididymis tissue protein Li 178

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145201.2 → NP_001138673.1  proline-rich acidic protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001138673.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL360181, BC071872, DQ884405
      Consensus CDS
      CCDS44498.1
      UniProtKB/TrEMBL
      A0A384NL10, A6XND8
      Related
      ENSP00000486265.1, ENST00000463201.2
      Conserved Domains (1) summary
      pfam15314
      Location:96 → 140
      PRAP; Proline-rich acidic protein 1, pregnancy-specific uterine

    2. NM_145202.5 → NP_660203.3  proline-rich acidic protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_660203.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL360181, BC071872
      Consensus CDS
      CCDS7679.1
      UniProtKB/Swiss-Prot
      B7ZL57, B7ZL58, E9KL31, Q5VWY4, Q7Z4X5, Q8IWR3, Q8NCS2, Q96NZ9
      UniProtKB/TrEMBL
      A0A384NL10
      Related
      ENSP00000416126.2, ENST00000433452.6
      Conserved Domains (1) summary
      pfam15314
      Location:105 → 149
      PRAP; Proline-rich acidic protein 1, pregnancy-specific uterine

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      133347373..133352683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      134302524..134307799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96NZ9.2 GenPept UniProtKB/Swiss-Prot:Q96NZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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