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    SULT1A2 sulfotransferase family 1A member 2 [ Homo sapiens (human) ]

    Gene ID: 6799, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SULT1A2provided by HGNC
    Official Full Name
    sulfotransferase family 1A member 2provided by HGNC
    Primary source
    HGNC:HGNC:11454
    See related
    Ensembl:ENSG00000197165 MIM:601292; AllianceGenome:HGNC:11454
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STP2; HAST4; P-PST; ST1A2; TSPST2; P-PST 2
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 25.0), small intestine (RPKM 22.6) and 13 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SULT1A2 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28591943..28597050, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28798642..28803752)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28603264..28608371, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:28549089-28550288 Neighboring gene nuclear protein 1, transcriptional regulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7310 Neighboring gene SAGA complex associated factor 29 Neighboring gene Sharpr-MPRA regulatory region 4245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610237-28610771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610772-28611305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28612139-28612653 Neighboring gene uncharacterized LOC107984835 Neighboring gene uncharacterized LOC124903674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28623750-28624250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28624498-28625048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28625049-28625598 Neighboring gene sulfotransferase family 1A member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28626587-28627161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7312 Neighboring gene nuclear pore complex interacting protein family member B8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and expression of a new form of human aryl sulfotransferase. Zhu X, et al. Int J Biochem Cell Biol, 1996 May. PMID 8697101
    2. Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults. Lv HY, et al. Sci Rep, 2023 May 4. PMID 37142702, Free PMC Article
    3. Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene. Gaedigk A, et al. Genomics, 1997 Mar 1. PMID 9119390
    4. Crystal structures of SULT1A2 and SULT1A1 *3: insights into the substrate inhibition and the role of Tyr149 in SULT1A2. Lu J, et al. Biochem Biophys Res Commun, 2010 May 28. PMID 20417180
    5. Sulfation of "estrogenic" alkylphenols and 17beta-estradiol by human platelet phenol sulfotransferases. Harris RM, et al. J Biol Chem, 2000 Jan 7. PMID 10617600

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults.
      Title: Association of SULT1A2 rs1059491 with obesity and dyslipidaemia in southern Chinese adults.
    2. Suggest SULT1A1/1A2 play a central role in furfuryl alcohol bioactivation and the formation of hemoglobin adducts.
      Title: Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2.
    3. The polymorphism of SULT1A2*2 is not associated with esophageal squamous cell carcinoma risk.
      Title: Genotypes of CYP1A1, SULT1A1 and SULT1A2 and risk of squamous cell carcinoma of esophagus: outcome of a case-control study from Kashmir, India.
    4. It metabolizes breast cancer drugs like afimoxifene and endoxifen by sulfation.
      Title: Sulfation of afimoxifene, endoxifen, raloxifene, and fulvestrant by the human cytosolic sulfotransferases (SULTs): A systematic analysis.
    5. SULT1A2 genotype also seems to play an important role in maintaining optimal levels of both 4OH-TAM and endoxifen.
      Title: Relationship between genotypes Sult1a2 and Cyp2d6 and tamoxifen metabolism in breast cancer patients.
    6. resequenced the SULT1A2 and SULT1A2 genes and identified 51 variations in ethnic Koreans, including 9 that were previously unknown. Allele frequencies, haplotype structures, LD blocks, and haplotype-tagging SNPs were determined.
      Title: Single nucleotide polymorphisms in SULT1A1 and SULT1A2 in a Korean population.
    7. the statistical hypothesis that SULT1A1 and SULT1A2 alleles are independently distributed was rejected; a strongly positive linkage was detected between SULT1A1*2 and SULT1A2*2 alleles in Turkey population
      Title: Genetic polymorphisms of sulfotransferases (SULT1A1 and SULT1A2) in a Turkish population.
    8. the structures of SULT1A2 and an allozyme of SULT1A1, SULT1A1 *3, bound with 3'-phosphoadenosine 5'-phosphate at 2.4 and 2.3A resolution, respectively, were determined.
      Title: Crystal structures of SULT1A2 and SULT1A1 *3: insights into the substrate inhibition and the role of Tyr149 in SULT1A2.
    9. SULT1A1/SULT1A2 gene complex showed suggestive haplotypic association in the family-based cardiovascular disease study, with the greatest increase in risk conferred by the SULT1A2 235T allele
      Title: Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2).
    10. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    EBI GWAS Catalog
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog
    Common variants at five new loci associated with early-onset inflammatory bowel disease.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC142287, MGC142289

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aryl sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavonol 3-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sulfotransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in catecholamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phenol-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 1A2
    Names
    aryl sulfotransferase 2
    arylamine sulfotransferase
    phenol sulfotransferase 2
    phenol-preferring phenol sulfotransferase2
    phenol-sulfating phenol sulfotransferase 2
    phenolic-metabolizing (P) form of PST
    sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
    thermostable phenol sulfotransferase
    NP_001045.2
    NP_001350792.2
    NP_001387187.1
    NP_001387188.1
    NP_001387189.1
    NP_001387190.1
    NP_001387191.1
    NP_001387192.1
    NP_001387193.1
    NP_803564.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032570.2 RefSeqGene

      Range
      5000..10107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001054.4 → NP_001045.2  sulfotransferase 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS10636.1
      UniProtKB/Swiss-Prot
      A9QY25, P50226, P78393, Q14CJ7
      UniProtKB/TrEMBL
      H3BRY5
      Related
      ENSP00000338742.4, ENST00000335715.9
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_001363863.3 → NP_001350792.2  sulfotransferase 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS86513.1
      UniProtKB/TrEMBL
      E9PKW4
      Related
      ENSP00000435271.1, ENST00000533150.5

    3. NM_001400258.1 → NP_001387187.1  sulfotransferase 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS10636.1
      UniProtKB/Swiss-Prot
      A9QY25, P50226, P78393, Q14CJ7

    4. NM_001400259.1 → NP_001387188.1  sulfotransferase 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS10636.1
      UniProtKB/Swiss-Prot
      A9QY25, P50226, P78393, Q14CJ7

    5. NM_001400260.1 → NP_001387189.1  sulfotransferase 1A2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC020765

    6. NM_001400261.1 → NP_001387190.1  sulfotransferase 1A2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC020765

    7. NM_001400262.1 → NP_001387191.1  sulfotransferase 1A2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC020765

    8. NM_001400263.1 → NP_001387192.1  sulfotransferase 1A2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC020765

    9. NM_001400264.1 → NP_001387193.1  sulfotransferase 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS10636.1
      UniProtKB/Swiss-Prot
      A9QY25, P50226, P78393, Q14CJ7

    10. NM_177528.4 → NP_803564.2  sulfotransferase 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS10636.1
      UniProtKB/Swiss-Prot
      A9QY25, P50226, P78393, Q14CJ7
      UniProtKB/TrEMBL
      H3BRY5
      Related
      ENSP00000378992.1, ENST00000395630.5
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    RNA

    1. NR_174455.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC020765

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      28591943..28597050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      28798642..28803752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50226.2 GenPept UniProtKB/Swiss-Prot:P50226

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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