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    Ipo13 importin 13 [ Mus musculus (house mouse) ]

    Gene ID: 230673, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ipo13provided by MGI
    Official Full Name
    importin 13provided by MGI
    Primary source
    MGI:MGI:2385205
    See related
    Ensembl:ENSMUSG00000033365 AllianceGenome:MGI:2385205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Imp13; Kap13; Ranbp13
    Summary
    Predicted to enable nuclear glucocorticoid receptor binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; olfactory epithelium; skin; submandibular gland primordium; and thymus primordium. Orthologous to human IPO13 (importin 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 70.7), ovary adult (RPKM 30.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ipo13 in Genome Data Viewer
    Location:
    4 D1; 4 53.76 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117751689..117772419, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117893268..117915222, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4652 Neighboring gene predicted gene 12841 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit B Neighboring gene STARR-positive B cell enhancer ABC_E10251 Neighboring gene DPH2 homolog Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 3 Neighboring gene artemin Neighboring gene RIKEN cDNA 9530034E10 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The nuclear transporter importin 13 is critical for cell survival during embryonic stem cell differentiation. Fatima S, et al. Biochem Biophys Res Commun, 2021 Jan 1. PMID 33333437
    2. Interactome of the inhibitory isoform of the nuclear transporter Importin 13. Fatima S, et al. Biochim Biophys Acta Mol Cell Res, 2017 Mar. PMID 27993670
    3. Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation. Gajewska KA, et al. Cells, 2022 Jun 12. PMID 35741036, Free PMC Article
    4. Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response. Gajewska KA, et al. Nat Commun, 2021 Oct 8. PMID 34625540, Free PMC Article
    5. Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation. Zohud BA, et al. Cell Death Dis, 2020 Oct 20. PMID 33082305, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation.
      Title: Nuclear Transporter IPO13 Is Central to Efficient Neuronal Differentiation.
    2. Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response.
      Title: Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response.
    3. Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.
      Title: Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.
    4. The nuclear transporter importin 13 is critical for cell survival during embryonic stem cell differentiation.
      Title: The nuclear transporter importin 13 is critical for cell survival during embryonic stem cell differentiation.
    5. Interactome of the inhibitory isoform of the nuclear transporter Importin 13 has been reported.
      Title: Interactome of the inhibitory isoform of the nuclear transporter Importin 13.
    6. Imp13 contributes to the neural cell-specific cargo trafficking and potentially to other functions during brain development.
      Title: Expression and subcellular distribution of imp13 are regulated in brain development.
    7. IPO13 has a stage-specific role in nuclear-cytoplasmic translocation of cargoes that accompanies meiotic differentiation of the mouse germ cells
      Title: Stage-specific Importin13 activity influences meiosis of germ cells in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18698

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    importin-13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419414.1 → NP_001406343.1  importin-13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627128

    2. NM_146152.3 → NP_666264.1  importin-13 isoform 1

      See identical proteins and their annotated locations for NP_666264.1

      Status: VALIDATED

      Source sequence(s)
      AK052257
      Consensus CDS
      CCDS18542.1
      UniProtKB/Swiss-Prot
      Q6ZQ60, Q8K0C1
      UniProtKB/TrEMBL
      Q3UDQ3
      Related
      ENSMUSP00000035989.6, ENSMUST00000036156.6
      Conserved Domains (3) summary
      smart00913
      Location:45 → 109
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:20 → 650
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:116 → 263
      Xpo1; Exportin 1-like protein

    RNA

    1. NR_185081.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627128

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      117751689..117772419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320147.3 → XP_017175636.1  importin-13 isoform X1

      Conserved Domains (5) summary
      smart00913
      Location:45 → 109
      IBN_N; Importin-beta N-terminal domain
      COG5101
      Location:20 → 650
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
      pfam08389
      Location:116 → 263
      Xpo1; Exportin 1-like protein
      pfam18773
      Location:402 → 441
      Importin_rep; Importin 13 repeat
      pfam18786
      Location:631 → 672
      Importin_rep_2; Importin 13 repeat

    RNA

    1. XR_003954914.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0C1.1 GenPept UniProtKB/Swiss-Prot:Q8K0C1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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