il1rapl1b interleukin 1 receptor accessory protein-like 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: il1rapl1bprovided by ZNC
Official Full Name: interleukin 1 receptor accessory protein-like 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090109-2
See related: Ensembl:ENSDARG00000104853 AllianceGenome:ZFIN:ZDB-GENE-090109-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable NAD(P)+ nucleosidase activity and NAD+ nucleotidase, cyclic ADP-ribose generating. Acts upstream of or within neuron remodeling and synapse organization. Located in axon terminus and neuronal cell body. Is expressed in olfactory bulb; optic tectum; peripheral olfactory organ; and telencephalon. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 21. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (44400864..44409852, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (43956357..43965345, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation.
Title: Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-1 receptor accessory protein-like 1-B

NP_001136054.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142582.1 → NP_001136054.1 interleukin-1 receptor accessory protein-like 1-B precursor

See identical proteins and their annotated locations for NP_001136054.1

Status: PROVISIONAL

Source sequence(s)

AB449368

UniProtKB/Swiss-Prot

B6ZK77

Related

ENSDARP00000131777.1, ENSDART00000162886.2

Conserved Domains (4) summary

cd00096
Location:263 → 348

Ig; Immunoglobulin domain

PHA02785
Location:7 → 334

PHA02785; IL-beta-binding protein; Provisional

pfam01582
Location:405 → 559

TIR; TIR domain

cl11960
Location:32 → 135

Ig; Immunoglobulin domain