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    Pik3r6 phosphoinositide-3-kinase regulatory subunit 5 [ Mus musculus (house mouse) ]

    Gene ID: 104709, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pik3r6provided by MGI
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 5provided by MGI
    Primary source
    MGI:MGI:2144613
    See related
    Ensembl:ENSMUSG00000046207 AllianceGenome:MGI:2144613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p84; p87PIKAP; p84 PIKAP; p87(PIKAP)
    Summary
    Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in lung adult (RPKM 5.1), mammary gland adult (RPKM 3.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pik3r6 in Genome Data Viewer
    Location:
    11 B3; 11 41.76 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68393845..68443524)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68503019..68552698)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68245166-68245319 Neighboring gene STARR-positive B cell enhancer mm9_chr11:68245418-68245719 Neighboring gene predicted gene, 32046 Neighboring gene phosphoinositide-3-kinase regulatory subunit 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68276328-68276529 Neighboring gene STARR-positive B cell enhancer ABC_E3959 Neighboring gene STARR-positive B cell enhancer ABC_E6997 Neighboring gene STARR-seq mESC enhancer starr_29817 Neighboring gene major facilitator superfamily domain containing 6-like Neighboring gene predicted gene, 40036

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PI3Kgamma inhibition combined with DNA vaccination unleashes a B-cell-dependent antitumor immunity that hampers pancreatic cancer.
      Title: PI3Kγ inhibition combined with DNA vaccination unleashes a B-cell-dependent antitumor immunity that hampers pancreatic cancer.
    2. Gbetagamma is a direct regulator of endogenous p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse neutrophils.
      Title: Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.
    3. These data demonstrate PI3Kgamma-dependent signalling downstream of IL-17RA, which plays a pivotal role in regulating IL-17 production in T cells.
      Title: Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels.
    4. GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
      Title: GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
    5. that genetic deletion of PI3Kgamma enhanced scratching behaviours in histamine-dependent and protease-activated receptor 2 (PAR-2)-dependent itch.
      Title: Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ).
    6. Results suggest that the CXCR2 and PI3Kgamma signaling pathway may represent a suitable target for the development of novel therapeutic strategies for human diseases characterized by vascular leakage.
      Title: A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability.
    7. PI3Kgamma has a role in the induction of CXCR3 on T cells
      Title: PI3Kgamma (PI3Kgamma) is essential for efficient induction of CXCR3 on activated T cells.
    8. ablation of PI3Kgamma reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells
      Title: Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells.
    9. p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP]
      Title: Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-3-kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of natural killer cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class IA ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class IB IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphoinositide 3-kinase regulatory subunit 6
    Names
    p84 PI3K adapter protein
    p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
    phosphoinositide 3-kinase gamma adapter protein of 87 kDa
    phosphoinositide-3-kinase, regulatory subunit 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004435.3 → NP_001004435.1  phosphoinositide 3-kinase regulatory subunit 6 isoform 2

      See identical proteins and their annotated locations for NP_001004435.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK153039, AY753194, BX629873, BY202586
      Consensus CDS
      CCDS24866.1
      UniProtKB/Swiss-Prot
      Q3U6Q4
      Related
      ENSMUSP00000099673.2, ENSMUST00000102613.8
      Conserved Domains (1) summary
      pfam10486
      Location:34 → 749
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    2. NM_001081566.2 → NP_001075035.1  phosphoinositide 3-kinase regulatory subunit 6 isoform 1

      See identical proteins and their annotated locations for NP_001075035.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform 1.
      Source sequence(s)
      AK153039, BX629873, BY202586
      Consensus CDS
      CCDS36186.1
      UniProtKB/Swiss-Prot
      Q3TBT5, Q3U6Q4, Q3UAY4, Q8K323
      Related
      ENSMUSP00000052522.7, ENSMUST00000060441.7
      Conserved Domains (1) summary
      pfam10486
      Location:34 → 753
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    RNA

    1. NR_126153.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK036623, AK151178, BX629873, BY202586
      Related
      ENSMUST00000153671.8

    2. NR_126154.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses alternate splice sites in two internal exons in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK036623, AK151178, AK153039, AL606831, BX629873, BY202586

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      68393845..68443524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314217.2 → XP_017169706.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X2

      Conserved Domains (1) summary
      pfam10486
      Location:32 → 546
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    2. XM_006531950.1 → XP_006532013.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X3

      Conserved Domains (1) summary
      pfam10486
      Location:32 → 499
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    3. XM_006531948.1 → XP_006532011.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X1

      Conserved Domains (1) summary
      pfam10486
      Location:38 → 716
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    4. XM_030245460.1 → XP_030101320.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X4

      Conserved Domains (1) summary
      pfam10486
      Location:35 → 394
      PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

    RNA

    1. XR_001779856.2 RNA Sequence

    2. XR_003949212.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U6Q4.1 GenPept UniProtKB/Swiss-Prot:Q3U6Q4

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