Mvk mevalonate kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mvkprovided by RGD
Official Full Name: mevalonate kinaseprovided by RGD
Primary source: RGD:621295
See related: EnsemblRapid:ENSRNOG00000049604 AllianceGenome:RGD:621295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MK; Lrbp
Summary: Enables several functions, including ATP binding activity; magnesium ion binding activity; and mevalonate kinase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and negative regulation of translation. Located in peroxisome. Human ortholog(s) of this gene implicated in hyperimmunoglobulinemia D periodic fever syndrome; lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 64.6), Liver (RPKM 63.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (47802002..47819503, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (42141391..42158893, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (47904266..47920457, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that significant conformational change on a flexible loop connecting the alpha6 and alpha7 helix is induced by the substrate mevalonate binding. Further, the study found that Asp204 is coordinated to the Mg2+ ion.
Title: Catalytic mechanism of mevalonate kinase revisited, a QM/MM study.
These data suggest that the association of LRBP with luteinizing hormone receptor mRNA results in the translocation of the messenger ribonucleoprotein complex to the p bodies leading to decapping and degradation.
Title: Association of luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies.
These results suggest that hCG-induced down-regulation of LHR mRNA expression is mediated by activation of cAMP/PKA/ERK pathways to increase miR-122 expression, which then increases LRBP expression through the activation of SREBPs.
Title: Regulation of LH receptor mRNA binding protein by miR-122 in rat ovaries.
during ligand-induced downregulation, LRBP translocates to ribosomes and associates with LHR mRNA to form an untranslatable ribonucleoprotein complex and inhibits LHR mRNA translation, paving the way to its degradation.
Title: Evidence for the association of luteinizing hormone receptor mRNA-binding protein with the translating ribosomes during receptor downregulation.
Comparison of animal MK protein alignments and structures with those of a MK protein from Streptococcus pneumoniae indicates that sequence differences between N- and C-terminal domains correlate with differences in interdomain angles.
Title: Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism.
Rat mevalonate kinase A141C variant enzyme has a new disulfide bond, which makes the variant protein enhance its thermal activity and resist to urea denaturation.
Title: Effect of a disulfide bond on mevalonate kinase.
structure of rat mevalonate kinase in complex with MgATP has been determined at 2.4-A resolution
Title: The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease.
LRBP is a translational inhibitor of LHR mRNA in the ovary
Title: Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovary.
results from kinetic studies showed the highly conserved histidine 20 is an important residue for the function of the enzyme
Title: Expression, purification, and characterization of His20 mutants of rat mevalonate kinase.
These results therefore show that LH receptor mRNA expression in the ovary is regulated post-transcriptionally by altering the rate of mRNA degradation by a specific mRNA binding protein.
Title: Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139619 (e-PCR)
- UniSTS:221703

RH136107 (e-PCR)
- UniSTS:210102

RH138776 (e-PCR)
- UniSTS:220863

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables mevalonate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mevalonate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables mevalonate kinase activity	IEA Inferred from Electronic Annotation more info
enables mevalonate kinase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in isoprenoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in isoprenoid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cholesterol biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in sterol metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
NOT located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mevalonate kinase

Names: LHR mRNA binding protein

NP_001380631.1

EC 2.7.1.36

NP_112325.1

EC 2.7.1.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393702.1 → NP_001380631.1 mevalonate kinase isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8I5Y175

Conserved Domains (1) summary

cl40731
Location:10 → 376

PLN02677; mevalonate kinase
NM_031063.2 → NP_112325.1 mevalonate kinase isoform 1

See identical proteins and their annotated locations for NP_112325.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P17256

UniProtKB/TrEMBL

A0A8I5Y175, A6J1Z8

Related

ENSRNOP00000077122.1, ENSRNOT00000097267.2

Conserved Domains (1) summary

cl40731
Location:10 → 377

PLN02677; mevalonate kinase