kdm6a.S lysine demethylase 6A S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: kdm6a.S
Official Full Name: lysine demethylase 6A S homeolog
Primary source: Xenbase:XB-GENE-960319
Locus tag: XELAEV_18014726mg
See related: EnsemblRapid:ENSXLAG00005025336 AllianceGenome:Xenbase:XB-GENE-960319
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: utx; uty; tutx; kdm6a; xtutx
Summary: Predicted to enable DNA binding activity; histone H3K27me2/H3K27me3 demethylase activity; and metal ion binding activity. Predicted to act upstream of or within heart development and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. Is expressed in visual system. Human ortholog(s) of this gene implicated in several diseases, including Kabuki syndrome; bladder urothelial carcinoma; gastrointestinal system cancer (multiple); lung carcinoma (multiple); and triple-receptor negative breast cancer. Orthologous to human KDM6A (lysine demethylase 6A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2S

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (47825148..47912228, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (44983620..45071133, complement)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables histone H3K27me2/H3K27me3 demethylase activity	IEA Inferred from Electronic Annotation more info
enables histone demethylase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of MLL3/4 complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysine demethylase 6A S homeolog

Names: lysine (K)-specific demethylase 6A S homeolog; ubiquitously transcribed tetratricopeptide repeat gene, Y-linked

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093305.1 → NP_001086774.1 lysine demethylase 6A S homeolog

See identical proteins and their annotated locations for NP_001086774.1

Status: PROVISIONAL

Source sequence(s)

BC077424

UniProtKB/TrEMBL

A0A974HV92, Q6AZS3

Related

ENSXLAP00005075561.1, ENSXLAT00005077139.1

Conserved Domains (8) summary

pfam02373
Location:1187 → 1295

JmjC; JmjC domain, hydroxylase

smart00558
Location:1153 → 1217

JmjC; A domain family that is part of the cupin metalloenzyme superfamily

COG0457
Location:37 → 317

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

pfam09606
Location:385 → 835

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

sd00006
Location:287 → 314

TPR; TPR repeat [structural motif]

pfam00515
Location:320 → 353

TPR_1; Tetratricopeptide repeat

pfam13414
Location:319 → 380

TPR_11; TPR repeat

pfam13431
Location:274 → 305

TPR_17; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

47825148..47912228 complement

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GenBank, FASTA, Sequence Viewer (Graphics)