Zfp266 zinc finger protein 266 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp266provided by MGI
Official Full Name: zinc finger protein 266provided by MGI
Primary source: MGI:MGI:1924769
See related: Ensembl:ENSMUSG00000060510 AllianceGenome:MGI:1924769
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5330440G10Rik; 5730601F06Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; liver; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to several human genes including ZNF561 (zinc finger protein 561) and ZNF562 (zinc finger protein 562). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 3.9), CNS E14 (RPKM 2.8) and 22 other tissues See more
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Genomic context

Location:: 9 A3; 9 7.56 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (20406364..20432715, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (20495068..20521419, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.
Title: B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236067

AW552317 (e-PCR)
- UniSTS:179430

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 561

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082485.1 → NP_001075954.1 zinc finger protein 561

See identical proteins and their annotated locations for NP_001075954.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC171206, BC089552, BM941296, CJ053742

Consensus CDS

CCDS52732.1

UniProtKB/TrEMBL

E9Q2S7

Related

ENSMUSP00000134217.2, ENSMUST00000174462.8

Conserved Domains (4) summary

smart00349
Location:41 → 97

KRAB; krueppel associated box

COG5048
Location:397 → 588

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:429 → 449

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:357 → 382

zf-H2C2_2; Zinc-finger double domain
NM_001135019.1 → NP_001128491.1 zinc finger protein 561

See identical proteins and their annotated locations for NP_001128491.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC171206, BC048701, BM941296, CJ053742

Consensus CDS

CCDS52732.1

UniProtKB/TrEMBL

E9Q2S7

Related

ENSMUSP00000066012.8, ENSMUST00000068296.8

Conserved Domains (4) summary

smart00349
Location:41 → 97

KRAB; krueppel associated box

COG5048
Location:397 → 588

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:429 → 449

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:357 → 382

zf-H2C2_2; Zinc-finger double domain