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    CASP8 caspase 8 [ Ornithorhynchus anatinus (platypus) ]

    Gene ID: 100082949, updated on 30-Apr-2024

    Summary

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    Gene symbol
    CASP8
    Gene description
    caspase 8
    See related
    Ensembl:ENSOANG00000004013
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ornithorhynchus anatinus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus
    Orthologs
    human mouse all
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    Genomic context

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    See CASP8 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    105 current mOrnAna1.pri.v4 (GCF_004115215.2) 7 NC_041734.1 (77782567..77802022, complement)

    Chromosome 7 - NC_041734.1Genomic Context describing neighboring genes Neighboring gene trafficking kinesin protein 2 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene caspase-8-like Neighboring gene caspase-10-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_041734.1 Chromosome 7 Reference mOrnAna1.pri.v4 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caspase-8
    Names
    caspase 8, apoptosis-related cysteine peptidase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Ornithorhynchus anatinus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mOrnAna1.pri.v4 Primary Assembly

    Genomic

    1. NC_041734.1 Reference mOrnAna1.pri.v4 Primary Assembly

      Range
      77782567..77802022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_029069379.2 → XP_028925212.1  caspase-8

      UniProtKB/TrEMBL
      F7A3C5
      Conserved Domains (3) summary
      cd08813
      Location:98 → 179
      DED_Caspase_8_r2; Death Effector Domain, repeat 2, of Caspase-8
      cd00032
      Location:210 → 467
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:3 → 84
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    Nucleotide Protein
    Heading Accession and Version

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